Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17A1.

Autor: Oksala R; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland. Electronic address: riikka.oksala@orionpharma.com., Moilanen A; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Riikonen R; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Rummakko P; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Karjalainen A; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Passiniemi M; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Wohlfahrt G; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Taavitsainen P; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Malmström C; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Ramela M; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Metsänkylä HM; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Huhtaniemi R; Institute of Biomedicine and Turku Center for Disease Modeling, University of Turku, Turku, Finland., Kallio PJ; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland., Mustonen MV; Orion Corporation Orion Pharma, Orionintie 1, FIN-02200, Espoo, Finland. Electronic address: mika.mustonen@orionpharma.com.

Publikováno v: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2019 Sep; Vol. 192, pp. 105115. Date of Electronic Publication: 2018 Feb 10.

Several genes encoding ribosomal proteins are over-expressed in prostate-cancer cell lines: confirmation of L7a and L37 over-expression in prostate-cancer tissue samples.

Autor: Vaarala MH; Biocenter Oulu and World Health Organization Collaborating Centre for Research on Reproductive Health, University of Oulu, Finland., Porvari KS, Kyllönen AP, Mustonen MV, Lukkarinen O, Vihko PT

Publikováno v: International journal of cancer [Int J Cancer] 1998 Sep 25; Vol. 78 (1), pp. 27-32.

Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.

Autor: Mustonen MV; Biocenter Oulu and Department of Clinical Chemistry, University of Oulu, Kajaanintie 50, FIN-90220 Oulu, Finland., Poutanen MH, Isomaa VV, Vihko PT, Vihko RK

Publikováno v: The Biochemical journal [Biochem J] 1997 Jul 01; Vol. 325 ( Pt 1), pp. 199-205.