Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mustafa Yalcinkaya"'
Autor:
Mustafa Yalcinkaya, Wenli Liu, Tong Xiao, Sandra Abramowicz, Ranran Wang, Nan Wang, Marit Westerterp, Alan R. Tall
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 4, Pp 100534- (2024)
The deposition of cholesterol-rich lipoproteins in the arterial wall triggers macrophage inflammatory responses, which promote atherosclerosis. The NLRP3 inflammasome aggravates atherosclerosis; however, cellular mechanisms connecting macrophage chol
Externí odkaz:
https://doaj.org/article/cddf3f7719774173a5a9834dd77868dc
Autor:
Mustafa Yalcinkaya, Wenli Liu, Mohammad N. Islam, Andriana G. Kotini, Galina A. Gusarova, Trevor P. Fidler, Eirini P. Papapetrou, Jahar Bhattacharya, Nan Wang, Alan R. Tall
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Despite the initial success of some drugs and vaccines targeting COVID-19, understanding the mechanism underlying SARS-CoV-2 disease pathogenesis remains crucial for the development of further approaches to treatment. Some patients with seve
Externí odkaz:
https://doaj.org/article/fcbd5a41a8c24100831b1baf29a4fe2e
Autor:
Wenli Liu, Nataliya Östberg, Mustafa Yalcinkaya, Huijuan Dou, Kaori Endo-Umeda, Yang Tang, Xintong Hou, Tong Xiao, Trevor P. Fidler, Sandra Abramowicz, Yong-Guang Yang, Oliver Soehnlein, Alan R. Tall, Nan Wang
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Elevated hematocrit is associated with cardiovascular risk; however, the causality and mechanisms are unclear. The JAK2V617F (Jak2VF) mutation increases cardiovascular risk in myeloproliferative disorders and in clonal hematopoiesis. Jak2VF mice with
Externí odkaz:
https://doaj.org/article/330ffd818b9243fea28a21408417d8eb
Autor:
Mustafa Yalcinkaya, Anja Kerksiek, Katrin Gebert, Wijtske Annema, Rahel Sibler, Silvija Radosavljevic, Dieter Lütjohann, Lucia Rohrer, Arnold von Eckardstein
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 4, Pp 492-504 (2020)
Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as well a
Externí odkaz:
https://doaj.org/article/5d1ba45ad54d475ca39156b754feed59
Autor:
Srividya Velagapudi, Peter Schraml, Mustafa Yalcinkaya, Hella A. Bolck, Lucia Rohrer, Holger Moch, Arnold von Eckardstein
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2188-2201 (2018)
Clear-cell renal cell carcinomas (ccRCCs) are characterized by inactivation of the von Hippel-Lindau (VHL) gene and intracellular lipid accumulation by unknown pathomechanisms. The immunochemical analysis of 356 RCCs revealed high abundance of apoA-I
Externí odkaz:
https://doaj.org/article/3c8ca98bf1194103a64c23f781da89b0
Autor:
Kaori Endo-Umeda, Eunyoung Kim, David G. Thomas, Wenli Liu, Huijuan Dou, Mustafa Yalcinkaya, Sandra Abramowicz, Tong Xiao, Per Antonson, Jan-Åke Gustafsson, Makoto Makishima, Muredach P. Reilly, Nan Wang, Alan R. Tall
Publikováno v:
Arterioscler Thromb Vasc Biol
Background: Cholesterol loaded macrophage foam cells are a prominent feature of atherosclerotic plaques. Single-cell RNA sequencing has identified foam cells as TREM2 (triggering receptor expressed on myeloid cells 2) positive populations with low ex
Autor:
Mustafa Yalcinkaya, Panagiotis Fotakis, Wenli Liu, Kaori Endo-Umeda, Huijuan Dou, Sandra Abramowicz, Tong Xiao, Peter Libby, Nan Wang, Alan R Tall, Marit Westerterp
Publikováno v:
Cardiovascular research.
Aims Neutrophil extracellular trap formation (NETosis) increases atherosclerotic plaque vulnerability and athero-thrombosis. However, mechanisms promoting NETosis during atherogenesis are poorly understood. We have shown that cholesterol accumulation
Autor:
Trevor P. Fidler, Kaori Endo Umeda, Sotirios Tsimikas, Tong Xiao, Alexander G. Bick, Huijuan Dou, Joseph L. Witztum, Alan R. Tall, Wenli Liu, Pradeep Natarajan, Sandra Abramowicz, Eirini P. Papapetrou, Brian Hardaway, Connor A. Emdin, Mustafa Yalcinkaya, Xiaoli Sun, Andriana G. Kotini, Xuchu Que, Malgorzata Olszewska, Nan Wang
Publikováno v:
Circulation, vol 144, iss 24
Circulation
Circulation
Supplemental Digital Content is available in the text.
Background: LNK/SH2B3 inhibits Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling by hematopoietic cytokine receptors. Genome-wide association studies have sh
Background: LNK/SH2B3 inhibits Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling by hematopoietic cytokine receptors. Genome-wide association studies have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e99a02ca298d715b9298d361a50fa9c
https://escholarship.org/uc/item/3fm1r2sg
https://escholarship.org/uc/item/3fm1r2sg
Autor:
Bettina Hesse, Jerzy-Roch Nofer, Mustafa Yalcinkaya, Renate Feuerborn, Alexander Lukasz, Andreas J. Hülsmeier, Srividya Velagapudi, Mingxia Liu, Lucia Rohrer, John S. Parks, Francesco Potì, Markus Stoffel, Arnold von Eckardstein, Dongdong Wang, Manuela Simoni, Anton Potapenko, Damir Perisa, Grigorios Panteloglou, Christina Christoffersen
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: ApoM enriches S1P (sphingosine-1-phosphate) within HDL (high-density lipoproteins) and facilitates the activation of the S1P 1 (S1P receptor type 1) by S1P, thereby preserving endothelial barrier function. Many protective functions exerted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ebb28b8484a2a6c4f305f747ab86c0
https://www.zora.uzh.ch/id/eprint/215359/
https://www.zora.uzh.ch/id/eprint/215359/
Publikováno v:
Diabetes
The frequent finding of low HDL cholesterol in patients with type 2 diabetes (T2D) or at increased risk for T2D has been traditionally interpreted as the consequence of hypertriglyceridemia and hyperacylemia, which are caused by insulin resistance an