Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice

Autor: Mohammad Kabbani, Philip Meuleman, Eleftherios Michailidis, Ype P. de Jong, Corrine Quirk, Chenhui Zou, Luis Chiriboga, Katherine A. High, Mustafa N. Yazicioglu, Koen Vercauteren, Roland W. Herzog, Xavier M. Anguela, Irene Zoluthkin

Publikováno v: Molecular Therapy. Methods & Clinical Development
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 189-198 (2020)

Adeno-associated virus (AAV) vector serotypes vary in their ability to transduce hepatocytes from different species. Chimeric mouse models harboring human hepatocytes have shown translational promise for liver-directed gene therapies. However, many v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425ecf07b20f36a97b45039f547d4ad7
http://europepmc.org/articles/PMC7326722

Genetic evidence for convergence of c-Kit– and α4 integrin–mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells

Autor: David R. Williams, Reuben Kapur, Bai Lin Tan, Jovencio Borneo, Jennifer McCarthy, David A. Ingram, Mustafa N. Yazicioglu

Publikováno v: Blood. 101:4725-4732

Mast cells play a critical role in host defense against a number of pathogens. Increased mast cell infiltration has been described in allergic asthma, in rheumatoid arthritis, and during helminthes infection. Despite the importance of mast cells in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea476fdafaf475712a1e15b73afc4a4a
https://doi.org/10.1182/blood-2002-08-2521

Modulation of CD8 T cell responses to AAV vectors with IgG-derived MHC class II epitopes

Autor: Mustafa N. Yazicioglu, Leslie P. Cousens, Federico Mingozzi, Robert J. Davidson, Daniel J. Hui, Jonathan D. Finn, Virginia Haurigot, Gary C. Pien, Yifeng Chen, David W. Scott, Anne S. De Groot, Shangzhen Zhou, Etiena Basner-Tschakarjan, George Buchlis, Alex Tai

Publikováno v: Molecular Therapy
Molecular Therapy, Cell Press, 2013, ⟨10.1038/mt.2013.166⟩
Molecular Therapy, 2013, ⟨10.1038/mt.2013.166⟩

International audience; Immune responses directed against viral capsid proteins constitute a main safety concern in the use of adeno-associated virus (AAV) as gene transfer vectors in humans. Pharmacological immunosuppression has been proposed as a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6342a62c7fb9a61f6f3145e291b5c77d
https://hal.archives-ouvertes.fr/hal-02881196

Mxi2 promotes stimulus-independent ERK nuclear translocation

Autor: Melanie H. Cobb, Maria T. Berciano, Mustafa N. Yazicioglu, Miguel Lafarga, Piero Crespo, Javier Rodriguez, Victoria Sanz-Moreno, Berta Casar

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Spatial regulation of ERK1/2 MAP kinases is an essential yet largely unveiled mechanism for ensuring the fidelity and specificity of their signals. Mxi2 is a p38 isoform with the ability to bind ERK1/2. Herein we show that Mxi2 has profound effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9262136eb5de2ecdce58d2915fbe7c6e
http://hdl.handle.net/10261/49398

The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy

Autor: Melanie H. Cobb, Aarati Ranganathan, Mustafa N. Yazicioglu

Publikováno v: The Journal of biological chemistry. 281(23)

The mitogen-activated protein (MAP) kinases ERK1 and ERK2 often accumulate in the nuclei of stimulated cells to mediate changes in transcription. The mechanisms underlying stimulus-dependent redistribution of these kinases remain unclear. We have use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16151cb8823d43965780f4010d14a118
https://pubmed.ncbi.nlm.nih.gov/16595679