Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mustafa Moroglu"'
Autor:
Gabriele Bassi, Nicholas Favalli, Miriam Vuk, Marco Catalano, Adriano Martinelli, Anika Trenner, Antonio Porro, Su Yang, Chuin Lean Tham, Mustafa Moroglu, Wyatt W. Yue, Stuart J. Conway, Peter K. Vogt, Alessandro A. Sartori, Jörg Scheuermann, Dario Neri
Publikováno v:
Advanced Science, Vol 7, Iss 22, Pp n/a-n/a (2020)
Abstract A versatile and Lipinski‐compliant DNA‐encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB‐D
Externí odkaz:
https://doaj.org/article/6523af672d2b411ba7e7080f84e45492
Publikováno v:
Synlett. 32:1236-1240
The stereoselective synthesis of substituted morpholine derivatives has been achieved through a two-step process involving diastereoselective addition of a Grignard reagent to a sulfinyl imine, followed by cyclization.
Autor:
Katrina H. Andrews, Marco Catalano, Federica Mazzieri, Dario Neri, Jörg Scheuermann, James Clayton, Mustafa Moroglu, Martina Bigatti, Stuart J. Conway, Petra Balbi
Publikováno v:
ChemMedChem, 15 (18)
DNA‐encoded chemical libraries (DECLs) are collections of chemical moieties individually coupled to distinctive DNA barcodes. Compounds can be displayed either at the end of a single DNA strand (i. e., single‐pharmacophore libraries) or at the ex
Autor:
David M. H. Ascough, Angelina R. Sekirnik, Mustafa Moroglu, Matthias Schiedel, Jos J. A. G. Kamps, Stuart J. Conway, Anna E. R. Chamberlain
Publikováno v:
Angewandte Chemie. 131:18096-18120
Autor:
Matthias Schiedel, Katrina H. Andrews, Corentine M.C. Laurin, Joseph P. Bluck, Stuart J. Conway, Prakriti Kalra, Panagis Filippakopoulos, James Clayton, Anthony K. N. Chan, Amy R. Scorah, Oleg Fedorov, Ester M. Hammond, Mustafa Moroglu, Kayla B. Vinh, William C. K. Pomerantz, Richard I. Cooper, Wilian A. Cortopassi, Pascal Heitel, Robert S. Paton, Anna Skwarska, Gabriella T. Perell, Kirsten E. Christensen, Larissa See, Hannah Bolland, Timothy P. C. Rooney, Sarah Picaud, Philip C. Biggin, Michael Brand
Publikováno v:
Journal of Medicinal Chemistry
CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development. They each comprise 10 domains through which they interact with >400 proteins, making them important transcriptional co-a
Autor:
Dario Neri, Renier Myburgh, Mustafa Moroglu, Richard A. Lerner, Roberto De Luca, Jörg Scheuermann, Nour L. Mozaffari, Jacopo Millul, Su Yang, Peter K. Vogt, Gabriele Bassi, Christian Pellegrino, Nicholas Favalli, Samuele Cazzamalli, Alessandro A. Sartori, Stuart J. Conway, Markus G. Manz, Anika Trenner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6f88014cd0f9680ae0c8adaa84384e
https://www.zora.uzh.ch/id/eprint/214655/
https://www.zora.uzh.ch/id/eprint/214655/
Autor:
Dario Neri, Renier Myburgh, Alessandro A. Sartori, Roberto De Luca, Mustafa Moroglu, Richard A. Lerner, Jörg Scheuermann, Peter K. Vogt, Christian Pellegrino, Anika Trenner, Nicholas Favalli, Nour L. Mozaffari, Jacopo Millul, Markus G. Manz, Stuart J. Conway, Su Yang, Gabriele Bassi, Samuele Cazzamalli
Publikováno v:
Nat Chem
Nature Chemistry, 13 (6)
Nature Chemistry, 13 (6)
The encoding of chemical compounds with amplifiable DNA tags facilitates the discovery of small-molecule ligands for proteins. To investigate the impact of stereo- and regiochemistry on ligand discovery, we synthesized a DNA-encoded library of 670,75
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f27f4210516abfa67212dfa115d1e2
https://doi.org/10.1038/s41557-021-00660-y
https://doi.org/10.1038/s41557-021-00660-y
Autor:
Ishna N. Mistry, Philip G. Humphreys, Panagis Filippakopoulos, Amy Hicks, Pavel Guzanov, Laura E. Jennings, Larissa See, Jessica K. Reynolds, Amy R. Scorah, Matthias Schiedel, Anna K. Mapp, James Clayton, David S. Hewings, Paul A. Bruno, Mustafa Moroglu, Charles N. G. Evans, Corentine M.C. Laurin, Stuart J. Conway, Joseph P. Bluck, Ester M. Hammond, Giulia Stazi, Sarah Picaud, Philip C. Biggin
Publikováno v:
Bioorganic & Medicinal Chemistry
Ligands for the bromodomain and extra-terminal domain (BET) family of bromodomains have shown promise as useful therapeutic agents for treating a range of cancers and inflammation. Here we report that our previously developed 3,5-dimethylisoxazole-ba
Autor:
David M. H. Ascough, Mustafa Moroglu, Jos J. A. G. Kamps, Stuart J. Conway, Anna E. R. Chamberlain, Angelina R. Sekirnik, Matthias Schiedel
Epigenetics is currently the focus of intense research across a broad range of disciplines due to its involvement in a multitude of biological processes and disease states. At the molecular level, epigenetic functions result partly from modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2761e3eb035e638213689465fe8a0217
https://ora.ox.ac.uk/objects/uuid:546d8049-e2d9-4ad9-b76e-f474de3f7593
https://ora.ox.ac.uk/objects/uuid:546d8049-e2d9-4ad9-b76e-f474de3f7593