Serological Markers of SARS-CoV-2 Reinfection.

Autor: Siddiqui SM; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Bowman KA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA., Zhu AL; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA., Fischinger S; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.; PhD Program in Immunology and Virology, University of Duisburg-Essen, Essen, Germany., Beger S; Space Exploration Technologies Corp., Hawthorne, California, USA., Maron JS; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.; PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, Massachusetts, USA., Bartsch YC; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA., Atyeo C; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.; PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, Massachusetts, USA., Gorman MJ; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA., Yanis A; Department of Pediatrics, Vanderbilt University Medical Centergrid.412807.8, Nashville, Tennessee, USA., Hultquist JF; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Lorenzo-Redondo R; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Ozer EA; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Simons LM; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Talj R; Department of Pediatrics, Vanderbilt University Medical Centergrid.412807.8, Nashville, Tennessee, USA., Rankin DA; Department of Pediatrics, Vanderbilt University Medical Centergrid.412807.8, Nashville, Tennessee, USA.; Vanderbilt Epidemiology PhD Program, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Chapman L; Space Exploration Technologies Corp., Hawthorne, California, USA., Meade K; Space Exploration Technologies Corp., Hawthorne, California, USA., Steinhart J; Space Exploration Technologies Corp., Hawthorne, California, USA., Mullane S; Space Exploration Technologies Corp., Hawthorne, California, USA., Siebert S; Space Exploration Technologies Corp., Hawthorne, California, USA., Streeck H; Institute of Virology, University Hospital, University of Bonn, and German Center for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany., Sabeti P; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Harvard T.H. Chan School of Public Health, Cambridge, Massachusetts, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, Massachusetts, USA., Halasa N; Department of Pediatrics, Vanderbilt University Medical Centergrid.412807.8, Nashville, Tennessee, USA., Musk ER; Space Exploration Technologies Corp., Hawthorne, California, USA., Barouch DH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.; Brigham and Women's Hospital, Department of Emergency Medicine, Boston, Massachusetts, USA.; Harvard Medical School, Harvard University, Cambridge, Massachusetts, USA., Menon AS; Space Exploration Technologies Corp., Hawthorne, California, USA., Nilles EJ; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Brigham and Women's Hospital, Department of Emergency Medicine, Boston, Massachusetts, USA.; Harvard Medical School, Harvard University, Cambridge, Massachusetts, USA.; Harvard Humanitarian Initiative, Boston, Massachusetts, USA., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, Massachusetts, USA.

Publikováno v: MBio [mBio] 2022 Feb 22; Vol. 13 (1), pp. e0214121. Date of Electronic Publication: 2022 Jan 25.

mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern.

Autor: Kaplonek P; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Fischinger S; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Cizmeci D; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Bartsch YC; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Kang J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Burke JS; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Shin SA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Dayal D; Space Exploration Technologies Corp, Hawthorne, CA, USA., Martin P; Space Exploration Technologies Corp, Hawthorne, CA, USA., Mann C; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Julg B; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Nilles EJ; Brigham and Women's Hospital, Boston, MA, USA., Musk ER; Space Exploration Technologies Corp, Hawthorne, CA, USA., Menon AS; Space Exploration Technologies Corp, Hawthorne, CA, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Saphire EO; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Andrea Carfi; Moderna Inc, Cambridge, MA, USA., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. Electronic address: galter@mgh.harvard.org.

Publikováno v: Immunity [Immunity] 2022 Feb 08; Vol. 55 (2), pp. 355-365.e4. Date of Electronic Publication: 2022 Jan 06.

Early cross-coronavirus reactive signatures of humoral immunity against COVID-19.

Autor: Kaplonek P; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Wang C; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Bartsch Y; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Fischinger S; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Gorman MJ; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Bowman K; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Kang J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Dayal D; Space Exploration Technologies Corporation, Hawthorne, CA, USA., Martin P; Space Exploration Technologies Corporation, Hawthorne, CA, USA., Nowak RP; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Villani AC; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Hsieh CL; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Charland NC; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., Gonye ALK; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Gushterova I; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Khanna HK; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., LaSalle TJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Lavin-Parsons KM; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., Lilley BM; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., Lodenstein CL; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., Manakongtreecheep K; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Margolin JD; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., McKaig BN; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., Rojas-Lopez M; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Russo BC; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sharma N; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Tantivit J; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Thomas MF; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sade-Feldman M; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Feldman J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Julg B; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Nilles EJ; Brigham and Women's Hospital, Boston, MA, USA., Musk ER; Space Exploration Technologies Corporation, Hawthorne, CA, USA., Menon AS; Space Exploration Technologies Corporation, Hawthorne, CA, USA., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Schmidt A; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Goldberg MB; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA, USA., Filbin MR; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., Hacohen N; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.

Publikováno v: Science immunology [Sci Immunol] 2021 Oct 15; Vol. 6 (64), pp. eabj2901. Date of Electronic Publication: 2021 Oct 15.

Adapting Disease Prevention Protocols for Human Spaceflight During COVID-19.

Autor: Petersen E, Pattarini JM, Mulcahy RA, Beger SB, Mitchell MR, Hu YD, Middleton KN, Frazier W, Mormann B, Esparza H, Asadi A, Musk ER, Alter G, Nilles E, Menon AS

Publikováno v: Aerospace medicine and human performance [Aerosp Med Hum Perform] 2021 Jul 01; Vol. 92 (7), pp. 597-602.

Discrete SARS-CoV-2 antibody titers track with functional humoral stability.

Autor: Bartsch YC; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Fischinger S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Institut für HIV Forschung, Universität Duisburg-Essen, Duisburg, Germany., Siddiqui SM; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chen Z; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Yu J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Gebre M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Atyeo C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Gorman MJ; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Zhu AL; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Kang J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Burke JS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Slein M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Gluck MJ; Space Exploration Technologies Corp, Hawthorne, CA, USA.; Icahn School of Medicine at Mount Sinai, Nw York, USA., Beger S; Space Exploration Technologies Corp, Hawthorne, CA, USA., Hu Y; Space Exploration Technologies Corp, Hawthorne, CA, USA., Rhee J; Space Exploration Technologies Corp, Hawthorne, CA, USA., Petersen E; Space Exploration Technologies Corp, Hawthorne, CA, USA., Mormann B; Space Exploration Technologies Corp, Hawthorne, CA, USA., Aubin MS; Harvard Humanitarian Initiative, Cambridge, MA, USA., Hasdianda MA; Brigham and Women's Hospital, Boston, MA, USA., Jambaulikar G; Brigham and Women's Hospital, Boston, MA, USA., Boyer EW; Brigham and Women's Hospital, Boston, MA, USA., Sabeti PC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard T.H. Chan School of Public Health, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Massachusetts Consortium on Pandemic Readiness, Cambridge, MA, USA., Barouch DH; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pandemic Readiness, Cambridge, MA, USA., Julg BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Musk ER; Space Exploration Technologies Corp, Hawthorne, CA, USA., Menon AS; Space Exploration Technologies Corp, Hawthorne, CA, USA. Anil.Menon@spacex.com., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. lauffen@mit.edu., Nilles EJ; Brigham and Women's Hospital, Boston, MA, USA. enilles@bwh.harvard.edu., Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. galter@mgh.harvard.edu.; Massachusetts Consortium on Pandemic Readiness, Cambridge, MA, USA. galter@mgh.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Feb 15; Vol. 12 (1), pp. 1018. Date of Electronic Publication: 2021 Feb 15.