Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Museer A. Lone"'
Autor:
Shabir Hassan, Museer A. Lone
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/9ac3fedca04941d1a4eec802f12ca1c9
Autor:
Charlotte Gehin, Museer A. Lone, Winston Lee, Laura Capolupo, Sylvia Ho, Adekemi M. Adeyemi, Erica H. Gerkes, Alexander P.A. Stegmann, Estrella López-Martín, Eva Bermejo-Sánchez, Beatriz Martínez-Delgado, Christiane Zweier, Cornelia Kraus, Bernt Popp, Vincent Strehlow, Daniel Gräfe, Ina Knerr, Eppie R. Jones, Stefano Zamuner, Luciano A. Abriata, Vidya Kunnathully, Brandon E. Moeller, Anthony Vocat, Samuel Rommelaere, Jean-Philippe Bocquete, Evelyne Ruchti, Greta Limoni, Marine Van Campenhoudt, Samuel Bourgeat, Petra Henklein, Christian Gilissen, Bregje W. van Bon, Rolph Pfundt, Marjolein H. Willemsen, Jolanda H. Schieving, Emanuela Leonardi, Fiorenza Soli, Alessandra Murgia, Hui Guo, Qiumeng Zhang, Kun Xia, Christina R. Fagerberg, Christoph P. Beier, Martin J. Larsen, Irene Valenzuela, Paula Fernández-Álvarez, Shiyi Xiong, Robert Śmigiel, Vanesa López-González, Lluís Armengol, Manuela Morleo, Angelo Selicorni, Annalaura Torella, Moira Blyth, Nicola S. Cooper, Valerie Wilson, Renske Oegema, Yvan Herenger, Aurore Garde, Ange-Line Bruel, Frederic Tran Mau-Them, Alexis B.R. Maddocks, Jennifer M. Bain, Musadiq A. Bhat, Gregory Costain, Peter Kannu, Ashish Marwaha, Neena L. Champaigne, Michael J. Friez, Ellen B. Richardson, Vykuntaraju K. Gowda, Varunvenkat M. Srinivasan, Yask Gupta, Tze Y. Lim, Simone Sanna-Cherchi, Bruno Lemaitre, Toshiyuki Yamaji, Kentaro Hanada, John E. Burke, Ana Marjia Jakšić, Brian D. McCabe, Paolo De Los Rios, Thorsten Hornemann, Giovanni D’Angelo, Vincenzo A. Gennarino
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesi
Externí odkaz:
https://doaj.org/article/47a113198d5649e88315ddec99f2067f
Autor:
Museer A. Lone, Mari J. Aaltonen, Aliza Zidell, Helio F. Pedro, Jonas A. Morales Saute, Shalett Mathew, Payam Mohassel, Carsten G. Bönnemann, Eric A. Shoubridge, Thorsten Hornemann
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons. Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT), which catalyzes the first step in the de novo synthesis of sphingolipids
Externí odkaz:
https://doaj.org/article/796026b8c3d74b45851ebb4515257d9e
Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts
Autor:
Gergely Karsai, Regula Steiner, Andres Kaech, Museer A. Lone, Arnold von Eckardstein, Thorsten Hornemann
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100122- (2021)
Hereditary sensory neuropathy type 1 (HSAN1) is a rare axonopathy, characterized by a progressive loss of sensation (pain, temperature, and vibration), neuropathic pain, and wound healing defects. HSAN1 is caused by several missense mutations in the
Externí odkaz:
https://doaj.org/article/607b15d735bf458aa2734d0c8984b135
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 11, Pp 2040-2050 (2016)
Long-chain bases (LCBs) are the precursors to ceramide and sphingolipids in eukaryotic cells. They are formed by the action of serine palmitoyl-CoA transferase (SPT), a complex of integral membrane proteins located in the endoplasmic reticulum. SPT a
Externí odkaz:
https://doaj.org/article/96168435d852491594fca8f06773988b
Autor:
Bryan A Martinez, Pedro Reis Rodrigues, Ricardo M Nuñez Medina, Prosenjit Mondal, Neale J Harrison, Museer A Lone, Amanda Webster, Aditi U Gurkar, Brock Grill, Matthew S Gill
Publikováno v:
eLife, Vol 9 (2020)
In the nematode C. elegans, insulin signaling regulates development and aging in response to the secretion of numerous insulin peptides. Here, we describe a novel, non-signaling isoform of the nematode insulin receptor (IR), DAF-2B, that modulates in
Externí odkaz:
https://doaj.org/article/57fd75f9b98c4541afadf21fad2aae7d
Autor:
Sriraksha Srinivasan, Andrea Di Luca, Arun T. John Peter, Charlotte Gehin, Museer A. Lone, Thorsten Hornemann, Giovanni D’Angelo, Stefano Vanni
Lipid Transfer Proteins (LTPs) are key players in cellular homeostasis and regulation, as they coordinate the exchange of lipids between different cellular organelles. Despite their importance, our mechanistic understanding of how LTPs function at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc94ae71ce9a76f5e249bfb1328dba1c
https://doi.org/10.1101/2023.04.11.536463
https://doi.org/10.1101/2023.04.11.536463
Autor:
Timothy J. Hines, Abigail L. D. Tadenev, Museer A. Lone, Courtney L. Hatton, Inseyah Bagasrawala, Morgane G. Stum, Kathy E. Miers, Thorsten Hornemann, Robert W. Burgess
Publikováno v:
Journal of Anatomy. 241:1169-1185
Animal models of neurodegenerative diseases such as inherited peripheral neuropathies sometimes accurately recreate the pathophysiology of the human disease, and sometimes accurately recreate the genetic perturbations found in patients. Ideally, mode
Publikováno v:
Advances in experimental medicine and biology. 1372
Sphingolipids (SL) are a class of chemically diverse lipids that have important structural and physiological functions in eukaryotic cells. SL entail a long chain base (LCB) as the common structural element, which is typically formed by the condensat
Autor:
Museer A. Lone, Mari J. Aaltonen, Aliza Zidell, Helio F. Pedro, Jonas Alex Morales Saute, Shalett Mathew, Payam Mohassel, Carsten Bonnemann, Eric A. Shoubridge, Thorsten Hornemann
SummaryAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons. Mutations in the SPTLC1 subunit of serine-palmitoyltransferase (SPT), which catalyzes the first step in the de novo synthesis of sphingolip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::343cbf999fb7c55c0b1eb07a6388b4fa
https://doi.org/10.1101/2022.04.29.490031
https://doi.org/10.1101/2022.04.29.490031