Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Musculoskeletal Pharmacology"'
Publikováno v:
F1000Research, Vol 6 (2017)
Chikungunya virus (CHIKV) has come to prominence as a global, re-emerging pathogen over the last two decades, progressing from sporadic, remote outbreaks to worldwide explosive epidemics. From contained, though considerable, outbreaks in the southern
Externí odkaz:
https://doaj.org/article/f5c34325a6b04c58a6e189ade3dfb70b
Publikováno v:
F1000Research, Vol 6 (2017)
Hidradenitis suppurativa (HS) is a devastating disease involving abscesses, sinus tracts, and inflammation classically affecting the axilla, groin, and/or anogenital region. Although the disease pathogenesis is not fully understood, recent advances s
Externí odkaz:
https://doaj.org/article/bbc3c9fadd674096a0647e40308a8e9b
Publikováno v:
F1000Research, Vol 6 (2017)
The accumulation of ‘senescent’ cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts. Tremendous progress has been ma
Externí odkaz:
https://doaj.org/article/196510948e2748f48c2d1b335fa6829a
Publikováno v:
F1000Research, Vol 6 (2017)
Gout is the most common crystal arthropathy and the leading cause of inflammatory arthritis. It is associated with functional impairment and, for many, a diminished health-related quality of life. Numerous studies have demonstrated the impact of gout
Externí odkaz:
https://doaj.org/article/f854ee317343479a93967b6a6e655bef
Autor:
Nina A. Ran, Aimee S. Payne
Publikováno v:
F1000Research, Vol 6 (2017)
Rituximab, a monoclonal antibody targeting the B cell marker CD20, was initially approved in 1997 by the United States Food and Drug Administration (FDA) for the treatment of non-Hodgkin lymphoma. Since that time, rituximab has been FDA-approved for
Externí odkaz:
https://doaj.org/article/e6edce74f5314baf8ef31d84931359b0
Autor:
Dafna D. Gladman
Publikováno v:
F1000Research, Vol 5 (2016)
This article reviews recent advances in psoriatic arthritis (PsA) over the past several years with emphasis on early diagnosis, better understanding of pathogenesis, and new therapeutic approaches. Early diagnosis is important, since people who prese
Externí odkaz:
https://doaj.org/article/aa31e18c9dcd4f95bb4e98587df76ff1
Autor:
Sergej M. Ostojic
Publikováno v:
F1000Research, Vol 5 (2016)
Molecular hydrogen (H2) has recently been recognized as a potential novel therapeutic agent in biomedicine. Initially proposed to be a possible treatment for certain types of neuromuscular disorders, cardio-metabolic diseases and cancer, H2 improved
Externí odkaz:
https://doaj.org/article/db6c56d054b043fcb859f1ab9db77c78
Publikováno v:
F1000Research, Vol 5 (2016)
Duchenne muscular dystrophy (DMD) is a recessive lethal inherited muscular dystrophy caused by mutations in the gene encoding dystrophin, a protein required for muscle fibre integrity. So far, many approaches have been tested from the traditional gen
Externí odkaz:
https://doaj.org/article/54357fc4668d42519d992c027de11afd
Autor:
David L. Scott
Publikováno v:
F1000Research, Vol 5 (2016)
The management of rheumatoid arthritis has changed dramatically over the last three decades. Improvements in clinical assessment have been a key driver of these changes. However, in the last five years, three areas of unresolved uncertainty have domi
Externí odkaz:
https://doaj.org/article/63ff85265c264a42b2e9eaab33570ad9
Publikováno v:
F1000Research, Vol 5 (2016)
Chronic itch is a significant health burden with few effective treatments. As such, itch researchers seek to understand the mechanisms behind itch and to find potential targets for treatment. The field of itch research is dynamic, and many advances h
Externí odkaz:
https://doaj.org/article/e86a5f6704f147b8adb0a711530ebdc2