Výsledky vyhledávání - "Muscarinic acetylcholine receptor M2"

Activating autoantibodies against G protein-coupled receptors in narcolepsy type 1

Autor: Markku Partinen, Anniina Alakuijala, Eemil Partinen, Maija Orjatsalo, Gerd Wallukat

Publikováno v: Sleep Medicine. 77:82-87

Study objectives: Narcolepsy type 1 is a rare hypersomnia of central origin, which is caused by loss of hypothalamic neurons that produce the neuropeptides hypocretin-1 and -2. Hypocretin-containing nerve terminals are found in areas known to play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2726a7dbdfbacf8ff3a0ab6e206b423b
https://doi.org/10.1016/j.sleep.2020.11.038

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Vibrational analysis of acetylcholine binding to the M2 receptor

Autor: Hirokazu Tsujimoto, Ryoji Suno, Yuji Sumii, Kohei Suzuki, Tomoya Nakagita, Takuya Kobayashi, Hideki Kandori, Norio Shibata, Kota Katayama, So Iwata

Publikováno v: RSC Advances. 11:12559-12567

The M2 muscarinic acetylcholine receptor (M2R) is a prototypical G protein-coupled receptor (GPCR) that responds to acetylcholine (ACh) and mediates various cellular responses in the nervous system. We recently established Attenuated Total Reflection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5afb26c6b2bed26679ddc53773f2fe65
https://doi.org/10.1039/d1ra01030a

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Long-Acting Muscarinic Antagonists Under Investigational to Treat Chronic Obstructive Pulmonary Disease

Autor: Paola Rogliani, Mario Cazzola, Angelo Coppola, Josuel Ora, Luigino Calzetta

Publikováno v: Journal of Experimental Pharmacology. 12:559-574

Introduction Bronchodilators are the cornerstone of chronic obstructive pulmonary disease (COPD) therapy and long-acting muscarinic antagonists (LAMAs) as a mono or combination treatment play a pivotal role. Several LAMAs are already available on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fa1e3857773ea1bd7dd3099a1b32f18
https://doi.org/10.2147/jep.s259330

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Excitatory cholinergic responses in mouse colon intramuscular interstitial cells of Cajal are due to enhanced Ca 2+ release via M 3 receptor activation

Autor: Kaitlin Huynh, Benjamin E. Rembetski, Aqeel Nizar, Salah A. Baker, Kenton M. Sanders, Bernard T. Drumm

Publikováno v: The FASEB Journal. 34:10073-10095

Colonic intramuscular interstitial cells of Cajal (ICC-IM) are associated with cholinergic varicosities, suggesting a role in mediating excitatory neurotransmission. Ca2+ release in ICC-IM activates Ano1, a Ca2+ -activated Cl- conductance, causing ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51c683e671cfa78f6d98a18232b4aa08
https://doi.org/10.1096/fj.202000672r

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Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M2 Receptor

Autor: Mengya Chen, Nicholas D. Holliday, Jianfei Wan, Günther Bernhardt, Max Keller, Corinna G. Gruber, Xueke She, Andrea Pegoli, Harald Hübner, Peter Gmeiner, Jessica Carpenter, David Wifling

Publikováno v: Journal of Medicinal Chemistry. 63:4133-4154

Fluorescently labeled dibenzodiazepinone-type muscarinic acetylcholine receptor (MR) antagonists, including dimeric ligands, were prepared using red-emitting cyanine dyes. Probes containing a fluorophore with negative charge showed high M2R affinitie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2e95ec7277d054214aa57332c1016c5
https://doi.org/10.1021/acs.jmedchem.9b02172

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Muscarinic receptors modulate Nerve Growth Factor production in rat Schwann-like adipose-derived stem cells and in Schwann cells

Autor: M. Taggi, Rita Canipari, Adam J Reid, Alessandro Faroni, A. Matera, Ada Maria Tata, Roberta Piovesana, Marzia Soligo, Luigi Manni

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Piovesana, R, Faroni, A, Taggi, M, Matera, A, Soligo, M, Canipari, R, Manni, L, Reid, A & Tata, A M 2020, ' Muscarinic receptors modulate Nerve Growth Factor production in rat Schwann-like adipose-derived stem cells and in Schwann cells ', Scientific Reports . https://doi.org/10.1038/s41598-020-63645-w

Regenerative capability of the peripheral nervous system after injury is enhanced by Schwann cells (SCs) producing several growth factors. The clinical use of SCs in nerve regeneration strategies is hindered by the necessity of removing a healthy ner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eeaf9572f40947163569b73d55552c9
http://link.springer.com/article/10.1038/s41598-020-63645-w

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Agonist-Specific Conformations of the M2 Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics

Autor: Jan Jakubík, Dominik Nelic, Alena Randáková, Esam E. El-Fakahany, John Boulos, Vladimír Doležal

Publikováno v: Journal of Chemical Information and Modeling. 60:2325-2338

Binding of muscarinic ligands, both antagonists and agonists, and their effects on the conformation of the M2 acetylcholine receptor were modeled in silico and compared to experimental data. After docking of antagonists to the M2 receptor in an inact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16d938cc8e2e91a58c99f604729a149e
https://doi.org/10.1021/acs.jcim.0c00041

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Structure–Activity Relationship Study of Psychostimulant Synthetic Cathinones Reveals Nanomolar Antagonist Potency of α-Pyrrolidinohexiophenone at Human Muscarinic M2 Receptors

Autor: Yiming Chen, Clinton E. Canal

Publikováno v: ACS Chemical Neuroscience. 11:960-968

Synthetic cathinones (SCs) are designer, psychostimulant drugs of abuse that primarily act on monoamine transporters; little is known about their off-target liability. Abuse of pyrrolidine-containi...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2474708e8547b82ac993ab43c928c1f
https://doi.org/10.1021/acschemneuro.0c00008

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Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M2R affinity

Autor: Andrea Pegoli, Lukas Grätz, Xueke She, Corinna G. Gruber, Christoph Müller, Max Keller

Publikováno v: RSC Med Chem

A series of fluorescent dibenzodiazepinone-type muscarinic acetylcholine M(2) receptor (M(2)R) ligands was synthesized using various fluorescent dyes (5-TAMRA, λ(ex)/λ(em) ≈ 547/576 nm; BODIPY 630/650, λ(ex)/λ(em) ≈ 625/640 nm; pyridinium dye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b21b6e2aee62a40aea804393e74bb26
https://doi.org/10.1039/d0md00137f

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Muscarinic M1 and M2 receptor subtypes play opposite roles in LPS-induced septic shock

Autor: Lu Liu, Mingyi Li, Bin Geng, Zhen Wang

Publikováno v: Pharmacological Reports. 71:1108-1114

Background To compare pharmacologic effects of pirenzepine and AF-DX116, a selective competitive antagonist for M1 and M2 subtype muscarinic cholinergic receptors (mAChRs), respectively, with atropine, a non-selective competitive antagonist for mAChR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e466ca9eb069c7c50ec1dc946fc6c0
https://doi.org/10.1016/j.pharep.2019.06.005

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