Výsledky vyhledávání - "Muscarinic Agonist"

Akademický článek

Multitargeting nature of muscarinic orthosteric agonists and antagonists

Autor: Jaromir Myslivecek

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Muscarinic receptors (mAChRs) are typical members of the G protein-coupled receptor (GPCR) family and exist in five subtypes from M1 to M5. Muscarinic receptor subtypes do not sufficiently differ in affinity to orthosteric antagonists or agonists; th

Externí odkaz: https://doaj.org/article/379ef35b45fa4cb6b1ee7ca14c238883

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Akademický článek

Argemone mexicana extract alleviates gastrointestinal disorders by stimulating muscarinic receptors and blocking voltage-gated L-type calcium channels

Autor: Rabia Iqbal, Irfan Hamid, Khalid Hussain Janbaz, Muhammad Furqan Akhtar, Ammara Saleem, Ali Sharif, Sohaib Peerzada, Bushra Akhtar, Kashif Sohail, Sajid Ali

Publikováno v: Asian Pacific Journal of Tropical Biomedicine, Vol 11, Iss 5, Pp 214-221 (2021)

Objective: To investigate the pharmacological potential of Argemone mexicana in treating constipation and emesis by using in vitro and in vivo models. Methods: The spasmogenic and spasmolytic effects were evaluated on isolated rabbit jejunum fragment

Externí odkaz: https://doaj.org/article/ca3567570cc84c46b49d0b465d93c948

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Akademický článek

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Akademický článek

Efficacy and safety of twice-daily glycopyrrolate in patients with stable, symptomatic COPD with moderate-to-severe airflow limitation: the GEM1 study

Autor: LaForce C, Feldman G, Spangenthal S, Eckert JH, Henley M, Patalano F, D’Andrea P

Publikováno v: International Journal of COPD, Vol 2016, Iss Issue 1, Pp 1233-1243 (2016)

Craig LaForce,1 Gregory Feldman,2 Selwyn Spangenthal,3 Joerg H Eckert,4 Michelle Henley,5 Francesco Patalano,4 Peter D’Andrea5 1North Carolina Clinical Research, Raleigh, NC, USA; 2South Carolina Pharmaceutical Research, Spartanburg, SC, USA; 3Amer

Externí odkaz: https://doaj.org/article/f846d7c3a6af47dd8f6ea7adba6b1c56

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Validation of Fenoterol to Study β2-Adrenoceptor Function in the Rat Urinary Bladder

Autor: Zeynep Elif Yesilyurt, Ebru Arioglu-Inan, Betül R Erdogan, Martin C. Michel

Publikováno v: Pharmacology. 107:116-121

Fenoterol is a β2-adrenoceptor (AR)-selective agonist that is commonly used to investigate relaxation responses mediated by β2-AR in smooth muscle preparations. Some data have questioned this because fenoterol had low potency in the rat urinary bla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58aee678712c3d8e0b8454045eb6252f
https://doi.org/10.1159/000519720

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Nicotinic aspects of the discriminative stimulus effects of arecoline

Autor: Gail Winger

Publikováno v: Behav Pharmacol

Despite the evidence that the muscarinic agonist arecoline is a drug of abuse throughout Southeast Asia, its stimulus characteristics have not been well studied. The goal of this work was to understand more about the mediation of discriminative stimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05390b504eb755a0cae2d41a77c66871
https://doi.org/10.1097/fbp.0000000000000652

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Ablation of p75NTR signaling strengthens gamma–theta rhythm interaction and counteracts Aβ-induced degradation of neuronal dynamics in mouse hippocampus in vitro

Autor: Pablo Dolz-Gaitón, Gefei Chen, Hugo Balleza-Tapia, Jan Johansson, André Fisahn, Yuniesky Andrade-Talavera

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry

Gamma and theta brain rhythms play important roles in cognition and their interaction can affect gamma oscillation features. Hippocampal theta oscillations depend on cholinergic and GABAergic input from the medial septum-diagonal band of Broca. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7571ddd8ff9a95c1afce61c8da19dcd9
https://doaj.org/article/b3fd79a913014ecaa1cd1b12c12111ff

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Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells

Autor: Richard A. Seidman, Heba Khattab, Jacqueline E. Broome, Jessie J. Polanco, Fraser J. Sim

Publikováno v: Scientific Reports. 12

Endogenous remyelination in demyelinating diseases such as multiple sclerosis is contingent upon the successful differentiation of oligodendrocyte progenitor cells (OPCs). Signaling via the Gαq-coupled muscarinic receptor (M1/3R) inhibits human OPC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ff30db00def53fc139b0a5520899ce
https://doi.org/10.1038/s41598-022-10095-1

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Akademický článek

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Comparison of the muscarinic antagonist effects of scopolamine and L-687,306

Autor: Gail Winger, Emily M. Jutkiewicz, James H. Woods

Publikováno v: Behav Pharmacol

This study aimed to use central and peripheral assays to compare the effects of the muscarinic antagonist scopolamine with those of a novel muscarinic antagonist, L-687,306 [(3R,4R)-3-(3-cyclopropyl-1,2,4,oxadiazol[5-yl]-1-azabicyclo[2.2.1]heptane. G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4559500cf769adda87c08ccc3eac5c82
https://doi.org/10.1097/fbp.0000000000000537

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