Výsledky vyhledávání - "Musarat Kabir"

Sequential Protein and Peptide Immunoaffinity Capture for Mass Spectrometry-Based Quantification of Total Human β-Nerve Growth Factor

Autor: Musarat Kabir, David Muirhead, Christopher Grace, Rosalin Arends, Adriaan Cleton, Hendrik Neubert

Publikováno v: Analytical Chemistry. 85:1719-1726

Nerve growth factor (NGF) is a neurotrophin that is implicated in the modulation of pain perception. Tanezumab, a humanized monoclonal antibody (mAb) specific for NGF, is highly potent in sequestering NGF and has demonstrated efficacy for treatment o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83bf61e82365c5bb48494c3235b07299
https://doi.org/10.1021/ac303031q

Zobrazit plný text záznamu

Serum Proteomic Abnormality Predating Screen Detection of Ovarian Cancer

Autor: Musarat Kabir, Paul Tempst, Usha Menon, Rainer Cramer, Stephane Camuzeaux, Alexander Gammerman, Volodya Vovk, John F. Timms, Zhiyuan Luo, Ilia Nouretdinov, Alexey Ya. Chervonenkis, Brian Burford, Ian Jacobs, Mike Waterfield, Josep Villanueva

Publikováno v: The Computer Journal. 52:326-333

Ovarian cancer is characterized by vague, non-specific symptoms, advanced stage at diagnosis and poor overall survival. A nested case control study was undertaken on stored serial serum samples from women who developed ovarian cancer and healthy cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b8a779063bfce6747f104065f531e60
https://doi.org/10.1093/comjnl/bxn021

Zobrazit plný text záznamu

Discovery of serum biomarkers of ovarian cancer using complementary proteomic profiling strategies

Autor: John F, Timms, Elif, Arslan-Low, Musarat, Kabir, Jenny, Worthington, Stephane, Camuzeaux, John, Sinclair, Joanna, Szaub, Babak, Afrough, Vladimir N, Podust, Evangelia-Ourania, Fourkala, Myriam, Cubizolles, Florian, Kronenberg, Eric T, Fung, Aleksandra, Gentry-Maharaj, Usha, Menon, Ian, Jacobs

Publikováno v: Proteomics. Clinical Applications

Purpose Ovarian cancer is a devastating disease and biomarkers for its early diagnosis are urgently required. Serum may be a valuable source of biomarkers that may be revealed by proteomic profiling. Herein, complementary serum protein profiling stra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c49f149fe58df31770270e80b0a219f3
https://pubmed.ncbi.nlm.nih.gov/25290619

Zobrazit plný text záznamu

Clinical pharmacokinetic assessment of an anti-MAdCAM monoclonal antibody therapeutic by LC-MS/MS

Autor: Mireia Fernández Ocaña, Musarat Kabir, Hendrik Neubert, Ian T. James, Christopher Grace, Guojun Yuan, Steven W. Martin

Publikováno v: Analytical chemistry. 84(14)

Liquid chromatography tandem mass spectrometry (LC-MS/MS) has been shown to be a viable tool for preclinical pharmacokinetic (PK) analysis of monoclonal antibody (mAb) therapeutics. This work describes free and total PK assays for the mAb PF-00547,65

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ae39ab1a69abf7e1249a28aa62e143
https://pubmed.ncbi.nlm.nih.gov/22816779

Zobrazit plný text záznamu

Serum peptide profiling using MALDI mass spectrometry: avoiding the pitfalls of coated magnetic beads using well-established ZipTip technology

Autor: Ali Tiss, Usha Menon, Ian Jacobs, Simon A. Gayther, Rainer Cramer, Stephane Camuzeaux, John F. Timms, Mike Waterfield, Musarat Kabir, Celia Smith

Publikováno v: Proteomics. 7

Blood represents a convenient diagnostic specimen for clinical analysis. Serum metabolites and peptides have the potential to serve as reliable indicators of progression from a normal to a diseased state. However, the presence of salts, lipids and hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6d53aa1304a9bad7f5d3cb052699a1
https://pubmed.ncbi.nlm.nih.gov/17893856

Zobrazit plný text záznamu