A photoredox-catalyzed approach for formal hydride abstraction to enable Csp3–H functionalization with nucleophilic partners (F, C, O, N, and Br/Cl)

Autor: Zhang, Yufei, Fitzpatrick, Nicholas A., Das, Mrinmoy, Bedre, Ishani P., Yayla, Hatice G., Lall, Manjinder S., Musacchio, Patricia Z.

Publikováno v: In Chem Catalysis 17 February 2022 2(2):292-308

An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4

Autor: Gonzalez-Valero, Angel, Reeves, Audrey G, Page, Annika CS, Moon, Patrick J, Miller, Edward, Coulonval, Katia, Crossley, Steven WM, Xie, Xiao, He, Dan, Musacchio, Patricia Z, Christian, Alec H, McKenna, Jeffrey M, Lewis, Richard A, Fang, Eric, Dovala, Dustin, Lu, Yipin, McGregor, Lynn M, Schirle, Markus, Tallarico, John A, Roger, Pierre P, Toste, F Dean, Chang, Christopher J

Publikováno v: Journal of the American Chemical Society, vol 144, iss 50

Activity-based protein profiling (ABPP) is a versatile strategy for identifying and characterizing functional protein sites and compounds for therapeutic development. However, the vast majority of ABPP methods for covalent drug discovery target highl

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https://escholarship.org/uc/item/7b37h649

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An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4.

Autor: Gonzalez-Valero A; Department of Chemistry, University of California, Berkeley, California 94720, United States., Reeves AG; Department of Chemistry, University of California, Berkeley, California 94720, United States., Page ACS; Department of Chemistry, University of California, Berkeley, California 94720, United States., Moon PJ; Department of Chemistry, University of California, Berkeley, California 94720, United States., Miller E; Department of Chemistry, University of California, Berkeley, California 94720, United States., Coulonval K; Faculté de Médecine, Institute of Interdisciplinary Research, Université Libre de Bruxelles, Campus Erasme, Brussels 1070, Belgium., Crossley SWM; Department of Chemistry, University of California, Berkeley, California 94720, United States., Xie X; Department of Chemistry, University of California, Berkeley, California 94720, United States., He D; Department of Chemistry, University of California, Berkeley, California 94720, United States., Musacchio PZ; Department of Chemistry, University of California, Berkeley, California 94720, United States., Christian AH; Department of Chemistry, University of California, Berkeley, California 94720, United States., McKenna JM; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Lewis RA; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Fang E; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Dovala D; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Lu Y; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., McGregor LM; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Schirle M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Tallarico JA; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Roger PP; Faculté de Médecine, Institute of Interdisciplinary Research, Université Libre de Bruxelles, Campus Erasme, Brussels 1070, Belgium., Toste FD; Department of Chemistry, University of California, Berkeley, California 94720, United States., Chang CJ; Department of Chemistry, University of California, Berkeley, California 94720, United States.; Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Dec 21; Vol. 144 (50), pp. 22890-22901. Date of Electronic Publication: 2022 Dec 09.