Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Musa A. Hassan"'
Autor:
Elisabeth M. D. L. van der Heijden, Lucas Lefevre, Anton Gossner, Thomas Tzelos, Timothy K. Connelley, Musa A. Hassan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Autologous administration of attenuated Theileria parva-infected cells induces immunity to T. parva in cattle. The mechanism of attenuation, however, is largely unknown. Here, we used RNA sequencing of pathogenic and attenuated T. parva-infe
Externí odkaz:
https://doaj.org/article/c52f956b50854040b714dafb8185cfef
Autor:
Ophélie Gervais, Carolina Peñaloza, Remi Gratacap, Athina Papadopoulou, Mariana Beltrán, Neil C. Henderson, Ross D. Houston, Musa A. Hassan, Diego Robledo
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Infectious Salmon Anaemia Virus (ISAV) is an Orthomixovirus that represents a large problem for salmonid aquaculture worldwide. Current prevention and treatment methods are only partially effective. Genetic selection and genome en
Externí odkaz:
https://doaj.org/article/62c45d1b7b464617b3b43f74fba4ab43
Autor:
Stephen Meek, Tom Watson, Lel Eory, Gus McFarlane, Felicity J. Wynne, Stephen McCleary, Laura E. M. Dunn, Emily M. Charlton, Chloe Craig, Barbara Shih, Tim Regan, Ryan Taylor, Linda Sutherland, Anton Gossner, Cosmin Chintoan-Uta, Sarah Fletcher, Philippa M. Beard, Musa A. Hassan, Finn Grey, Jayne C. Hope, Mark P. Stevens, Monika Nowak-Imialek, Heiner Niemann, Pablo J. Ross, Christine Tait-Burkard, Sarah M. Brown, Lucas Lefevre, Gerard Thomson, Barry W. McColl, Alistair B. Lawrence, Alan L. Archibald, Falko Steinbach, Helen R. Crooke, Xuefei Gao, Pentao Liu, Tom Burdon
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Infectious diseases of farmed and wild animals pose a recurrent threat to food security and human health. The macrophage, a key component of the innate immune system, is the first line of defence against many infectious agents and
Externí odkaz:
https://doaj.org/article/cf7ad4f4a1df46abb42ac71785840eab
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background Differential isoform usage is an important driver of inter-individual phenotypic diversity and is linked to various diseases and traits. However, accurately detecting the differential usage of different gene transcripts between gr
Externí odkaz:
https://doaj.org/article/6fda9da562a0459999f066c257750bfb
Autor:
Yifan Wang, Lamba Omar Sangaré, Tatiana C. Paredes-Santos, Musa A. Hassan, Shruthi Krishnamurthy, Anna M. Furuta, Benedikt M. Markus, Sebastian Lourido, Jeroen P. J. Saeij
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Using a genome-wide CRISPR screen, the authors here identify Toxoplasma genes that counteract the anti-parasitic activity of interferon gamma in murine macrophages. One of these genes, dense granule protein GRA45, is critical for the trafficking of G
Externí odkaz:
https://doaj.org/article/68a66b36b97c4e1683d45043107bffd4
Autor:
Anton Gossner, Musa A. Hassan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
The obligate intracellular parasite, Toxoplasma gondii, is highly prevalent among livestock species. Although cattle are generally resistant to Toxoplasma strains circulating in Europe and North America, the underlying mechanisms are largely unknown.
Externí odkaz:
https://doaj.org/article/449302c80ab046d1b326dc9b3f061a91
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background The lytic cycle of the protozoan parasite Toxoplasma gondii, which involves a brief sojourn in the extracellular space, is characterized by defined transcriptional profiles. For an obligate intracellular parasite that is shielded
Externí odkaz:
https://doaj.org/article/53802098d15f41d5820641442029b948
Autor:
Waqas Khokhar, Musa A. Hassan, Anireddy S. N. Reddy, Saurabh Chaudhary, Ibtissam Jabre, Lee J. Byrne, Naeem H. Syed
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
Alternative splicing (AS) of pre-mRNAs contributes to transcriptome diversity and enables plants to generate different protein isoforms from a single gene and/or fine-tune gene expression during different development stages and environmental changes.
Externí odkaz:
https://doaj.org/article/a8558e39100f42e3aa29680c4b13168f
Autor:
Yifan Wang, Kimberly M. Cirelli, Patricio D. C. Barros, Lamba Omar Sangaré, Vincent Butty, Musa A. Hassan, Patricia Pesavento, Asli Mete, Jeroen P. J. Saeij
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT Upon invasion of Lewis rat macrophages, Toxoplasma rapidly induces programmed cell death (pyroptosis), which prevents Toxoplasma replication, possibly explaining the resistance of the Lewis rat to Toxoplasma. Using a chemical mutagenesis scr
Externí odkaz:
https://doaj.org/article/1462382b1c284276b4916c2eb582db60
Autor:
Avner Fink, Musa A. Hassan, Nihal A. Okan, Michal Sheffer, Ana Camejo, Jeroen P. J. Saeij, Dennis L. Kasper
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT Differences among individuals in susceptibility to infectious diseases can be modulated by host genetics. Much of the research in this field has aimed to identify loci within the host genome that are associated with these differences. In mic
Externí odkaz:
https://doaj.org/article/93e1f57b28df4c19b8f08d7f48160d00