Enabling P-glycoprotein inhibition in multidrug resistant cancer through the reverse targeting of a quinidine-PEG conjugate

Autor: Snyder, Sarah, Murundi, Shamanth, Crawford, Lindsey, Putnam, David

Publikováno v: In Journal of Controlled Release 10 January 2020 317:291-299

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Selective Accumulation of Near Infrared-Labeled Multivalent Quinidine Copolymers in Tumors Overexpressing P-Glycoprotein: Potential for Noninvasive Diagnostic Imaging.

Autor: Robertus CM; Meinig School of Biomedical Engineering, Cornell University, 237 Tower Road, Ithaca, New York 14853-0001, United States., Snyder SM; Meinig School of Biomedical Engineering, Cornell University, 237 Tower Road, Ithaca, New York 14853-0001, United States., Curley SM; Meinig School of Biomedical Engineering, Cornell University, 237 Tower Road, Ithaca, New York 14853-0001, United States., Murundi SD; Department of Biological and Environmental Engineering, Cornell University, 111 Wing Drive, Ithaca, New York 14853-0001, United States., Whitman MA; Meinig School of Biomedical Engineering, Cornell University, 237 Tower Road, Ithaca, New York 14853-0001, United States., Fischbach C; Meinig School of Biomedical Engineering, Cornell University, 237 Tower Road, Ithaca, New York 14853-0001, United States.; Kavli Institute at Cornell for Nanoscale Science, Cornell University, 245 Feeney Way, Ithaca, New York 14853, United States., Putnam D; Meinig School of Biomedical Engineering, Cornell University, 237 Tower Road, Ithaca, New York 14853-0001, United States.; Smith School of Chemical and Biomolecular Engineering, Cornell University, 113 Ho Plaza, Ithaca, New York 14853, United States.

Publikováno v: ACS applied bio materials [ACS Appl Bio Mater] 2023 Aug 21; Vol. 6 (8), pp. 3117-3130. Date of Electronic Publication: 2023 Jul 27.