P2X4 Receptors Mediate Ca2+ Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors

Autor: Ewan St. John Smith, Peace Atakpa-Adaji, Colin W. Taylor, Ruth D. Murrell-Lagnado, Sin-Lih Tan, Muruj Barri

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10492, p 10492 (2021)

The P2X4 purinergic receptor is targeted to endolysosomes, where it mediates an inward current dependent on luminal ATP and pH. Activation of P2X4 receptors was previously shown to trigger lysosome fusion, but the regulation of P2X4 receptors and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d051f7a3e30c625859db0b7f959d5afb

Automatic segmentation of focal adhesions from mouse embryonic fibroblasts

Autor: Majid Hafezparast, Constantino Carlos Reyes-Aldasoro, Muruj Barri

Publikováno v: ISBI

This work describes an automatic algorithm for the segmentation and quantification of focal adhesions from mouse embryonic fibroblasts. The main challenges solved by this algorithm are: the variability of the intensity of the focal adhesions, the det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeaeaa84db3e9a41fb42b53536b434ca
https://openaccess.city.ac.uk/id/eprint/12811/1/Lamellipodia_ISBI2015.pdf

DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy

Autor: Elizabeth M. C. Fisher, Wenhan Deng, Anna Kuta, Violetta Soura, Giampietro Schiavo, Majid Hafezparast, Caroline Garrett, Muruj Barri

Publikováno v: Brain : a journal of neurology. 137(Pt 7)

Mutations in the gene encoding the heavy chain subunit (DYNC1H1) of cytoplasmic dynein cause spinal muscular atrophy with lower extremity predominance, Charcot-Marie-Tooth disease and intellectual disability. We used the legs at odd angles (Loa) (DYN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886e1361f23a217562969c1170313c32
https://pubmed.ncbi.nlm.nih.gov/24755273