Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Murty N. Arimilli"'
Autor:
Mohan Rao, Robert C. Andrews, Robert Rothlein, Tove' C. Bolken, Murty N. Arimilli, Adnan M. M. Mjalli, Tariq Andrea, Katrina L. Owens, Dennis E. Hruby, Chelsea M. Byrd
Publikováno v:
Journal of Virology. 78:12147-12156
By using a homology-based bioinformatics approach, a structural model of the vaccinia virus (VV) I7L proteinase was developed. A unique chemical library of ∼51,000 compounds was computationally queried to identify potential active site inhibitors.
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 20:1411-1414
A series of aryl ester prodrugs of cyclic HPMPC have been synthesized and their physicochemical properties, pharmacokinetics and metabolism have been evaluated. Chemical stability was dependent on the orientation of the exo-cyclic ligand; the equator
Autor:
Reza Oliyai, Cathy M. Sueoka-Lennen, Jeng-Pyng Shaw, William A. Lee, Kenneth C. Cundy, Robert J. Jones, Murty N. Arimilli
Publikováno v:
Pharmaceutical Research. 16:1687-1693
Purpose. The chemical, enzymatic, and biological stabilities and physical properties of a series of salicylate and aryl ester prodrugs of the antiviral agent, cyclic HPMPC, were evaluated to support the selection of a lead compound for clinical devel
Autor:
Murty N. Arimilli, Kenneth C. Cundy, William A. Lee, Reza Oliyai, Choung U. Kim, Cathy M. Sueoka, Jeng-Pyng Shaw
Publikováno v:
Pharmaceutical Research. 14:1824-1829
Purpose. A series of prodrugs designed to enhance the oral bioavailability of the antiretroviral agent 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA; 1) have been synthesized, including a bis-(acyloxymethyl) ester 2 and a series of bis-(alkoxycarbo
Publikováno v:
Synthetic Communications. 23:131-134
A short and efficient synthesis of a C-7 CH2 analog of 4-demethoxyadriamycin-9-one as a nearly equimolar mixture of diastereomers is described. The Diels-Alder cycloaddition, deoxygenation and concomitant enolization-tautomerization can be done in a
Autor:
Stephen Ireland, Robert Andrews, Murty N. Arimilli, Hendrik Jan Thibaut, Frank J. M. van Kuppeveld, Ward Heggermont, Erik De Clercq, Johan Neyts, Kjerstin Lanke, Taleb H. Al-Tel, Lonneke van der Linden, Armando M. De Palma
Publikováno v:
Antimicrobial Agents and Chemotherapy, 53, 1850-7
Antimicrobial agents and chemotherapy, 53(5), 1850-1857. American Society for Microbiology
Antimicrobial Agents and Chemotherapy, 53, 5, pp. 1850-7
Antimicrobial agents and chemotherapy, 53(5), 1850-1857. American Society for Microbiology
Antimicrobial Agents and Chemotherapy, 53, 5, pp. 1850-7
Contains fulltext : 79778.pdf (Publisher’s version ) (Open Access) A novel compound, TTP-8307, was identified as a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits viral RNA synthesis in a dose-dependent ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61c6f10e4a80695ecdb2bc3a3c2c3ae
http://hdl.handle.net/2066/79778
http://hdl.handle.net/2066/79778
Publisher Summary This chapter presents that acyclic nucleoside and nucleotide analogs shows substantial clinical utility against a variety of viral infections. Ganciclovir is in use for cytomegalovirus (CMV) infections and prophylaxis in immunocompr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c321b78ab1a41889047f132539ed65bb
https://doi.org/10.1016/s1075-8593(99)80004-5
https://doi.org/10.1016/s1075-8593(99)80004-5
Autor:
Patrick Augustijns, Lieve Naesens, N. Bischofberger, Guy Van den Mooter, Murty N. Arimilli, Erik De Clercq, Choung U. Kim, Pieter Annaert
Publikováno v:
ResearcherID
Europe PubMed Central
Europe PubMed Central
To overcome the low oral bioavailability of the highly potent and selective antiretroviral agent ( R )-9-(2-phosphonylmethoxypropyl)adenine (PMPA), a new lipophilic ester derivative, i.e., the bis(isopropyloxycarbonyloxymethyl)-ester [bis(POC)-PMPA],
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb819d39faf8ca4bf856ae6c58a42429
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074535500007&KeyUID=WOS:000074535500007
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074535500007&KeyUID=WOS:000074535500007