Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Murty Chengalvala"'
Autor:
Charles William Mann, Lloyd M. Garrick, Matthew D. Vera, Linda Shanno, Jeffrey C. Pelletier, John F. Rogers, Diane B. Hauze, Jay E. Wrobel, Daniel M. Green, Irene Feingold, Murty Chengalvala, John F. Mehlmann, Joseph T. Lundquist, Joshua E. Cottom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2512-2515
Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH antagonists ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1eec816e736d1f8d7e039cc0629e060
https://doi.org/10.1016/j.bmcl.2010.02.099
https://doi.org/10.1016/j.bmcl.2010.02.099
Autor:
Lloyd M. Garrick, John F. Mehlmann, Diane B. Hauze, Joshua E. Cottom, Daniel M. Green, Jeffrey C. Pelletier, Murty Chengalvala, Irene Feingold, Joseph T. Lundquist, John F. Rogers, Charles William Mann, Linda Shanno, Jay E. Wrobel, Christine Huselton, Wenling Kao, Kees Kenneth L
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1986-1990
A previous report described the serum LH suppression pharmacology of the 2-phenyl-4-piperazinyl-benzimidazole N-ethyluracil GnRH receptor antagonist 1 following oral administration in rats. A series of small heterocycles were appended to the 2-(4-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e42c70637294bea6edaaf45f2b6b18
https://doi.org/10.1016/j.bmcl.2009.02.043
https://doi.org/10.1016/j.bmcl.2009.02.043
Autor:
William R. Adams, Irene Feingold, John F. Mehlmann, Cesario O Tio, Joshua E. Cottom, Jay E. Wrobel, Jeffrey C. Pelletier, Daniel M. Green, John F. Rogers, James W. Jetter, Murty Chengalvala, Joseph T. Lundquist, Charles William Mann, Linda Shanno, Ronald L. Magolda, Diane B. Hauze, Gregory S. Kopf, Christine Huselton
Publikováno v:
Journal of Medicinal Chemistry. 52:2148-2152
A potent, highly insoluble, GnRH antagonist with a 2-phenyl-4-piperazinylbenzimidazole template and a quinoxaline-2,3-dione pharmacophore was modified to maintain GnRH antagonist activity and improve in vitro pharmaceutical properties. Structural cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b2a453cf8d2bd665d3484f6156095d
https://doi.org/10.1021/jm801572m
https://doi.org/10.1021/jm801572m
Autor:
Igor Goljer, Jeffrey C. Pelletier, Diane S. Andraka, Linda Shanno, Daniel M. Green, Murty Chengalvala, Warren W. Hurlburt
Publikováno v:
Journal of Combinatorial Chemistry. 11:117-125
2-Trifluoromethyl-4-aminobenzimidazoles were previously identified by screening to be active antagonists of the gonadotropin releasing hormone receptor (GnRH-R). Structure activity relationships and diversity oriented synthesis are shown here in grea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3b6be5cd17587b69aa72547377e3e3
https://doi.org/10.1021/cc800106h
https://doi.org/10.1021/cc800106h
Publikováno v:
Expert Opinion on Therapeutic Patents. 13:59-66
Androgens regulate diverse physiological processes involving both reproductive and non-reproductive functions. Most of the signalling effects of androgens are mediated through the androgen receptor (AR), a member of the nuclear receptor superfamily o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b05cef401a6d63941d7fd0a1ddda6b
https://doi.org/10.1517/13543776.13.1.59
https://doi.org/10.1517/13543776.13.1.59
Autor:
Daniel S. Gonder, Warren W. Hurlburt, Beverly Kostek, Robert Mastroeni, Murty Chengalvala, Donald E. Frail, Ashok R. Bapat
Publikováno v:
Biochemistry. 40:814-821
Rat osteo-testicular protein tyrosine phosphatase (OST-PTP), expressed in osteoblasts and testis, is a receptor-like transmembrane protein with two tandemly repeated phosphatase domains in the cytoplasmic region. In this report, we show that the firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e26de961dcf71779271c06e5f14fbfd
https://doi.org/10.1021/bi0019996
https://doi.org/10.1021/bi0019996
Publikováno v:
Journal of Biochemical and Biophysical Methods. 38:163-170
The quantitation of inositol phosphates (IPs), mediators of certain signal transduction processes, typically involves laborious and time consuming conventional ion-exchange chromatography procedures. We have developed a high throughput microtiter pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7683630704ea6525b2672c9efc6816
https://doi.org/10.1016/s0165-022x(98)00046-3
https://doi.org/10.1016/s0165-022x(98)00046-3
Autor:
Bheem M. Bhat, Michael D. Lubeck, Surendra K. Dheer, Krishna K. Murthy, Murty Chengalvala, Robert H. Purcell, Ramesh A. Bhat
Publikováno v:
Vaccine. 15:335-339
Human adenovirus vectors containing intact or largely deleted E3 region were used to construct adenovirus-hepatitis B recombinant viruses (Ad-HepB) and shown to produce substantial amount of recombinant protein, hepatitis B surface antigen (HBsAg), i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec693f114ee7b01073f6658f05f4e560
https://doi.org/10.1016/s0264-410x(96)00174-0
https://doi.org/10.1016/s0264-410x(96)00174-0
Autor:
Mark S. Wade, Bheem M. Bhat, Surendra K. Dheer, Pranab K. Chanda, Ramesh A. Bhat, Michael D. Lubeck, Shaw-Guang Lee, Shridhara Murthy, Jorg W. Eichberg, Paul P. Hung, Krishna K. Murthy, Murty Chengalvala, Alan R. Davis, Robert J. Natuk, Satoshi Mizutani
Publikováno v:
AIDS Research and Human Retroviruses. 10:1443-1449
Recombinant adenovirus (Ad)-human immunodeficiency virus (HIV) vaccines expressing HIVIIIB Env and Gag proteins were evaluated for immunogenicity in chimpanzees following intranasal administration. When Ad7-, Ad4-, and Ad5-vectored vaccines were admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97cd8a5261ded643b0c722593dd32d69
https://doi.org/10.1089/aid.1994.10.1443
https://doi.org/10.1089/aid.1994.10.1443
Autor:
Steven K. Vernon, James M. Wilhelm, Mark S. Wade, Pranab K. Chanda, R J Natuk, Shaw-Guang Lee, Shridhara Murthy, Jorg W. Eichberg, Michael D. Lubeck, Krishna K. Murthy, Satoshi Mizutani, Paul P. Hung, Alan R. Davis, Surendra K. Dheer, Murty Chengalvala
Publikováno v:
AIDS Research and Human Retroviruses. 9:395-404
Recombinant human adenovirus (Ad) type 4-, 5-, and 7-vectored vaccines expressing either the HIV env or gag-protease genes were tested for immunogenicity in three chimpanzees. The first phase of the vaccination protocol consisted of a primary and two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ad4b2d6e261f3deb62e077c7fe37a9
https://doi.org/10.1089/aid.1993.9.395
https://doi.org/10.1089/aid.1993.9.395