Mechanisms of sodium-glucose cotransporter-2 inhibition: Insights from Large-Scale Proteomics

Autor: Ferrannini, Ele, Murthy, Ashwin C., Lee, Yong-ho, Muscelli, Elza, Weiss, Sophie, Ostroff, Rachel M., Sattar, Naveed, Williams, Stephen A., Ganz, Peter

Objective To assess the effects of empagliflozin, a selective SGLT2 inhibitor, on broad biological systems through proteomics.Research Design and Methods 3,713 proteins were quantified using aptamer-based proteomics in 144 paired plasma samples obtai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d92ca363acf657bc83335ae1c8d526c
https://doi.org/10.2337/figshare.12195018.v1

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Abstract 11946: Comparison of Unsupervised Learning Approaches Applied to Electronic Health Record Traits in Heart Failure

Autor: Reza, Nosheen, Bone, William P, Singhal, Pankhuri, Yang, Yifan, Verma, Anurag, Murthy, Ashwin C, Denduluri, Srinivas, Adusumalli, Srinath, Ritchie, Marylyn, Cappola, Thomas P

Publikováno v: Circulation (Ovid); November 2021, Vol. 144 Issue: Supplement 1 pA11946-A11946, 1p

Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics.

Autor: Ferrannini E; CNR Institute of Clinical Physiology, Pisa, Italy ferranni@ifc.cnr.it., Murthy AC; Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA., Lee YH; Department of Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea., Muscelli E; CNR Institute of Clinical Physiology, Pisa, Italy., Weiss S; SomaLogic, Inc., Boulder, CO., Ostroff RM; SomaLogic, Inc., Boulder, CO., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K., Williams SA; SomaLogic, Inc., Boulder, CO., Ganz P; Zuckerberg San Francisco General Hospital, University of California, San Francisco, CA.

Publikováno v: Diabetes care [Diabetes Care] 2020 Sep; Vol. 43 (9), pp. 2183-2189. Date of Electronic Publication: 2020 Jun 11.