Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development.

Autor: Indrani Rajan, Katerina V Savelieva, Gui-Lan Ye, Ching-Yun Wang, Murtaza M Malbari, Carl Friddle, Thomas H Lanthorn, Wandong Zhang

Publikováno v: PLoS ONE, Vol 4, Iss 8, p e6612 (2009)

Histone deacetylase 4 (HDAC4) has been associated with muscle & bone development [1]-[6]. N-terminal MEF2 and RUNX2 binding domains of HDAC4 have been shown to mediate these effects in vitro. A complete gene knockout has been reported to result in pr

Externí odkaz: https://doaj.org/article/c224c4ce01274467af46d908f44c626f

Differential sensitivity to SSRI and tricyclic antidepressants in juvenile and adult mice of three strains

Autor: Ruth Ritter, Murtaza M. Malbari, Thomas H. Lanthorn, Stephen P. Wray, Vladimir M. Pogorelov, Kevin B. Baker, Kristina W. Davis, Brenda Gerhardt, Katerina V. Savelieva, Sara S. Mason

Publikováno v: European journal of pharmacology. 602(2-3)

Clinical studies have shown differential efficacy of several antidepressants in children and adolescents compared to adults, yet few animal studies have sought to characterize this phenomenon. We compared effects of fluoxetine and imipramine in two c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5574a88e13c1ad7c670cbef130dc6be
https://pubmed.ncbi.nlm.nih.gov/19038246

Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.

Autor: Zviran A; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Schulman RC; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Shah M; New York Genome Center, New York, NY, USA., Hill STK; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Deochand S; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Khamnei CC; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Maloney D; New York Genome Center, New York, NY, USA., Patel K; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Liao W; New York Genome Center, New York, NY, USA., Widman AJ; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wong P; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Callahan MK; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ha G; Division of Public Health Services, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Reed S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rotem D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Frederick D; Division of Surgical Oncology, Massachussetts General Hospital, Boston, MA, USA., Sharova T; Division of Surgical Oncology, Massachussetts General Hospital, Boston, MA, USA., Miao B; Division of Surgical Oncology, Massachussetts General Hospital, Boston, MA, USA., Kim T; Division of Surgical Oncology, Massachussetts General Hospital, Boston, MA, USA., Gydush G; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rhoades J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huang KY; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Omans ND; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Bolan PO; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Lipsky AH; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Ang C; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Malbari M; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Spinelli CF; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Kazancioglu S; New York Genome Center, New York, NY, USA., Runnels AM; New York Genome Center, New York, NY, USA., Fennessey S; New York Genome Center, New York, NY, USA., Stolte C; New York Genome Center, New York, NY, USA., Gaiti F; New York Genome Center, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Inghirami GG; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Adalsteinsson V; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Houck-Loomis B; New York Genome Center, New York, NY, USA., Ishii J; New York Genome Center, New York, NY, USA., Wolchok JD; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boland G; Division of Surgical Oncology, Massachussetts General Hospital, Boston, MA, USA., Robine N; New York Genome Center, New York, NY, USA., Altorki NK; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Landau DA; New York Genome Center, New York, NY, USA. dlandau@nygenome.org.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. dlandau@nygenome.org.

Publikováno v: Nature medicine [Nat Med] 2020 Jul; Vol. 26 (7), pp. 1114-1124. Date of Electronic Publication: 2020 Jun 01.