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Autor:
Marcus F. Boehm, Lin Zhang, Lin Zhi, Michael R. McClurg, Elain Berger, Murriel Wagoner, Dale E. Mais, Carla M. Suto, Peter J. A. Davies, Richard A. Heyman, Alex M. Nadzan
Publikováno v:
Journal of Medicinal Chemistry. 38:3146-3155
Structural modifications of the retinoid X receptor (RXR) selective compound 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2- naphthyl)ethenyl]benzoic acid (LGD1069), which is currently in phase I/IIA clinical trials for cancer and dermatological in