Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis B.

Autor: Wildum S; Roche Pharma, Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland., Korolowicz KE; Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, United States., Suresh M; Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, United States., Steiner G; Roche Pharma, Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland., Dai L; Roche Pharma, Research and Early Development, Roche Innovation Center Shanghai, Shanghai, China., Li B; Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, United States., Yon C; Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, United States., De Vera Mudry MC; Roche Pharma, Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland., Regenass-Lechner F; Roche Pharma, Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland., Huang X; Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, United States., Hong X; Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, United States., Murreddu MG; Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, United States., Kallakury BV; Department of Pathology, Georgetown University Medical Center, Washington, DC, United States., Young JAT; Roche Pharma, Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland., Menne S; Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 May 23; Vol. 13, pp. 884113. Date of Electronic Publication: 2022 May 23 (Print Publication: 2022).

Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks.

Autor: Suresh M; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC, United States., Li B; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC, United States., Murreddu MG; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC, United States., Gudima SO; Department of Microbiology, Molecular Genetics & Immunology, University of Kansas Medical Center, Kansas City, KS, United States., Menne S; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Jul 22; Vol. 12, pp. 713420. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021).

Measurement of Antiviral Effect and Innate Immune Response During Treatment of Primary Woodchuck Hepatocytes.

Autor: Murreddu MG; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC, USA., Suresh M; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC, USA., Gudima SO; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS, USA., Menne S; Department of Microbiology & Immunology, Georgetown University Medical Center, Medical-Dental Building, Room C301, 3900 ReservoirRoad, Washington, DC, 20057, USA. sm923@georgetown.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1540, pp. 277-294.

Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B.

Autor: Fletcher SP; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America., Chin DJ; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America., Gruenbaum L; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America., Bitter H; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America., Rasmussen E; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America., Ravindran P; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America., Swinney DC; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America., Birzele F; Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Penzberg, Germany., Schmucki R; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Lorenz SH; Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Penzberg, Germany., Kopetzki E; Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Penzberg, Germany., Carter J; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America., Triyatni M; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Thampi LM; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America., Yang J; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America., AlDeghaither D; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America., Murreddu MG, Cote P; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America., Menne S; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2015 Sep 09; Vol. 11 (9), pp. e1005103. Date of Electronic Publication: 2015 Sep 09 (Print Publication: 2015).

Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma.

Autor: Morazzani EM; Department of Entomology, Fralin Life Science Institute, Virginia Tech, Blacksburg, Virginia, United States of America., Wiley MR, Murreddu MG, Adelman ZN, Myles KM

Publikováno v: PLoS pathogens [PLoS Pathog] 2012 Jan; Vol. 8 (1), pp. e1002470. Date of Electronic Publication: 2012 Jan 05.