Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Murray S. Webb"'
Autor:
Jennifer I Hare, Robert W Neijzen, Malathi Anantha, Nancy Dos Santos, Natashia Harasym, Murray S Webb, Theresa M Allen, Marcel B Bally, Dawn N Waterhouse
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62349 (2013)
To investigate the use of liposomal irinotecan (Irinophore C™) plus or minus 5-fluorouracil (5-FU) for the treatment of colorectal cancer.The effect of irinotecan (IRI) and/or 5-FU exposure times on cytotoxicity was assessed in vitro against HT-29
Externí odkaz:
https://doaj.org/article/d91877b9f732401faa35bb016a25a1b5
Autor:
Natalia Zisman, Marcel B. Bally, Magali Zeisser-Labouebe, Sylvia S. W. Ng, Hilary J. Anderson, Murray S. Webb, Anitha Thomas, Norbert Maurer, Michel Roberge, Irina Manisali, Elizabeth Donohue
Publikováno v:
Journal of Cancer
Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to chemotherapy. It has been described as requiring elevated autophagy for growth and inhibiting autophagy has been proposed as a treatment strategy. To date, all preclinical reports and cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e420429eaad9e07b9f61d6cc5b3e31a2
https://doi.org/10.7150/jca.7030
https://doi.org/10.7150/jca.7030
Publikováno v:
Handbook of Small Animal Imaging ISBN: 9781315373591
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bcf928f248849a781820ba6590907f
https://doi.org/10.1201/b19052-35
https://doi.org/10.1201/b19052-35
Autor:
Jason Crawford, Ingrid Barta, Murray S. Webb, R. Wilder Scott, Eric Simonson, Kelly M. McNagny, Leola N. Chow, Michael R. Hughes, Irina Manisali, Vionarica Gusti, T. Michael Underhill, Petra Schreiner, Betina Y. Y. Ng, Samantha Lecour, Bernard C. Lo
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151765 (2016)
PLoS ONE
PLoS ONE
Modulation of chemokine CXCL12 and its receptor CXCR4 has been implicated in attenuation of bleomycin (BLM)-induced pulmonary fibrosis and carbon tetrachloride (CCl4)-induced hepatic injury. In pulmonary fibrosis, published reports suggest that colla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd2d1a8f22b6695269bd7737bf6687b
http://europepmc.org/articles/PMC4801399?pdf=render
http://europepmc.org/articles/PMC4801399?pdf=render
Autor:
Dana Masin, Jason Crawford, Pieter R. Cullis, Geoff Winters, Matthew K Wong, Lawrence N. Amankwa, Marco A. Ciufolini, Marcel B. Bally, Lindsay Heller, Masuna Srinivasulu, Norbert Maurer, Natashia Harasym, Murray S. Webb, Igor V. Zhigaltsev, Dawn Waterhouse
Publikováno v:
Journal of Controlled Release. 144:332-340
Hydrophobic uncharged drugs such as docetaxel are difficult to encapsulate and retain in liposomal nanoparticles (LNP). In this work we show that a weak base derivative of docetaxel can be actively loaded into LNP using pH gradient loading techniques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599c5be6b0bad7424b6af6a516b1d4be
https://doi.org/10.1016/j.jconrel.2010.02.029
https://doi.org/10.1016/j.jconrel.2010.02.029
Autor:
Dawn Waterhouse, Hong Yan, Malathi Anantha, Murray S. Webb, Jehan Alnajim, Jason Zastre, Marcel B. Bally, Euan Ramsay
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 68:607-617
We determined whether the method used to encapsulate irinotecan into 1,2-distearoyl-sn-glycero-phosphocholine/cholesterol (DSPC/Chol; 55:45 mol%) liposomes influenced: (i) irinotecan release rate and (ii) therapeutic efficacy. DSPC/Chol (55:45 mol%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f004fbdb9985998a90566d946c84c4
https://doi.org/10.1016/j.ejpb.2007.08.011
https://doi.org/10.1016/j.ejpb.2007.08.011
Publikováno v:
Recent Patents on Drug Delivery & Formulation. 1:185-194
It is challenging to develop innovative, as well as commercially viable, lipid-based drug delivery systems for the treatment of cancer because of the breadth of existing intellectual property that limits freedom-to-operate. For example, novel composi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b121be6521bedfb3be59253efc8b5d
https://doi.org/10.2174/187221107782331593
https://doi.org/10.2174/187221107782331593
Autor:
Euan Ramsay, Dana Masin, Donald T. T. Yapp, Nancy Boman, Murray S. Webb, Gigi N.C. Chiu, Pieter R. Cullis, Marcel B. Bally
Publikováno v:
Letters in Drug Design & Discovery. 4:426-433
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fed2ec7c984d5e45161ec8b06149ffe
https://doi.org/10.2174/157018007781387782
https://doi.org/10.2174/157018007781387782
Autor:
Malathi Anantha, Anne-Marie Doppen, Christine Allen, Nancy Dos Santos, Göran Karlsson, Murray S. Webb, Lacey Samuels, Kelly A.K. Cox, Gail Kenner, Katarina Edwards, Ryan C. Gallagher, Marcel B. Bally
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1768(6):1367-1377
The incorporation of poly(ethylene glycol) (PEG)-conjugated lipids in lipid-based carriers substantially prolongs the circulation lifetime of liposomes. However, the mechanism(s) by which PEG-lipids achieve this have not been fully elucidated. It is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c096f238df448627ccdf411c80f9f8