Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Murray J B, Brown"'
Autor:
Ashleigh J. Burke, Thomas M. Lister, James R. Marshall, Murray J. B. Brown, Richard Lloyd, Anthony P. Green, Nicholas J. Turner
Publikováno v:
ChemCatChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab39e11eb8d853bf2eb1cae851b538d9
https://doi.org/10.1002/cctc.202300256
https://doi.org/10.1002/cctc.202300256
Autor:
Freideriki Michailidou, Tomas Lebl, Alexandra M. Z. Slawin, Sunil Vishnuprasadji Sharma, Murray J. B. Brown, Rebecca Jane Miriam Goss
Publikováno v:
Molecules, Vol 25, Iss 23, p 5513 (2020)
Fluorinated nucleoside analogues have attracted much attention as anticancer and antiviral agents and as probes for enzymatic function. However, the lack of direct synthetic methods, especially for 2′,3′-dideoxy-2′,3′-difluoro nucleosides, ha
Externí odkaz:
https://doaj.org/article/cdcccc80b6af495089b9188addd0cb9a
Publikováno v:
ChemCatChem. 13:3565-3580
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d0976719d419a01cc0485185f028be5
https://doi.org/10.1002/cctc.202100688
https://doi.org/10.1002/cctc.202100688
Publikováno v:
Green Chemistry. 23:828-837
ATP recycling systems are required to avoid the addition of stoichiometric quantities of cofactor and facilitate industrial implementation of ATP-dependent enzymes. One factor that limits the biocatalytic application of these enzymes is the lack of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3eb48925764413affbc6a548dee64ef
https://doi.org/10.1039/d0gc03830j
https://doi.org/10.1039/d0gc03830j
Autor:
Jonathan S. Trimble, Rebecca Crawshaw, Florence J. Hardy, Colin W. Levy, Murray J. B. Brown, Douglas E. Fuerst, Derren J. Heyes, Richard Obexer, Anthony P. Green
Publikováno v:
Trimble, J, Crawshaw, R, Hardy, F, Levy, C, Brown, M J B, Fuerst, D E, Heyes, D, Obexer, R & Green, A 2022, ' A Designed Photoenzyme for Enantioselective [2+2]-Cycloadditions ', Nature., vol. 611, no. 7937 . https://doi.org/10.1038/s41586-022-05335-3
The ability to programme new modes of catalysis into proteins would allow the development of enzyme families with functions beyond those found in nature. To this end, genetic code expansion methodology holds particular promise, as it allows the site-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed299e8a23e39f23f13dd65b4bdded8
https://pubmed.ncbi.nlm.nih.gov/36130727
https://pubmed.ncbi.nlm.nih.gov/36130727
Autor:
Sandy S. Chang, Joseph Hosford, Mahesh J. Sanganee, Anne A. Ollis, Christopher M. MacDermaid, Leigh Anne F. Ihnken, Murray J. B. Brown, Douglas E. Fuerst, Jonathan Latham, Diluar Khan, Markus Schober, Gheorghe-Doru Roiban
Publikováno v:
Nature Catalysis. 2:909-915
Imine reductases catalyse the reductive amination of aldehydes or ketones with amines to produce chiral amines—a key transformation in the preparation of fine chemicals and active pharmaceutical ingredients. Although significant progress has been r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c5679819baaf967e2370855b4545f2
https://doi.org/10.1038/s41929-019-0341-4
https://doi.org/10.1038/s41929-019-0341-4
Autor:
Martin Rüdiger, Chun-wa Chung, Jonathan P. Hutchinson, Christopher C. Arico-Muendel, Svetlana L. Belyanskaya, Allison Olszewski, Nerina Dodic, Duncan S. Holmes, Anthony Dossang, Andrew C. Pearce, Alistair M. Jagger, Steve Wilson, Adriana Ordóñez, David A. Lomas, Toral Jakhria, Iain Uings, Hitesh Dave, Zhengrong Zhu, Stefan J. Marciniak, Alexis Denis, Lionel Trottet, Kathrine J. Smith, Murray J. B. Brown, Imran Haq, James A. Irving, Steve Skinner, Margaret Neu, Diana Klimaszewska, Peter Eddershaw, Riccardo Ronzoni, James E. Rowedder, Andrew Brewster, John Liddle, Emilie Jigorel, Jeffrey A. Messer, Ken Lind, Rebecca Terry
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have used a DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e32df3c3fc2fd491449ec31b9633ea9
https://doi.org/10.15252/emmm.202013167
https://doi.org/10.15252/emmm.202013167
Autor:
Alexandra M. Z. Slawin, Rebecca J. M. Goss, Freideriki Michailidou, Murray J. B. Brown, Sunil V. Sharma, Tomas Lebl
Publikováno v:
Molecules
Volume 25
Issue 23
Molecules, Vol 25, Iss 5513, p 5513 (2020)
Volume 25
Issue 23
Molecules, Vol 25, Iss 5513, p 5513 (2020)
Fluorinated nucleoside analogues have attracted much attention as anticancer and antiviral agents and as probes for enzymatic function. However, the lack of direct synthetic methods, especially for 2&prime
3&prime
dideoxy-2&prime
diflu
3&prime
dideoxy-2&prime
diflu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a6437e9a552d4d8de87ed0b1d3112c
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
Autor:
Stefan J. Marciniak, Martin Rüdiger, Hitesh Dave, Jonathan P. Hutchinson, Margaret Neu, Anthony Dossang, Riccardo Ronzoni, Lionel Trottet, Adriana Ordóñez, Chun-wa Chung, Christopher C. Arico-Muendel, Alexis Denis, Allison Olszewski, Andrew C. Pearce, Ken Lind, Peter Eddershaw, Andrew Brewster, Rebecca Terry, Jeffrey A. Messer, John Liddle, Iain Uings, Emilie Jigorel, James A. Irving, Nerina Dodic, Zhengrong Zhu, Kathrine J. Smith, Duncan S. Holmes, Steve Skinner, Steve Wilson, David A. Lomas, Diana Klimaszewska, James E. Rowedder, Murray J. B. Brown, Alistair M. Jagger, Toral Jakhria, Imran Haq, Svetlana L. Belyanskaya
Severe α1-antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1-antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have used a DNA-encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5dc4b6dd1fbecffcf82db1f278226c
https://doi.org/10.1101/2020.07.26.217661
https://doi.org/10.1101/2020.07.26.217661
Autor:
Chun-wa Chung, Sunil Sharma, William J. Leavens, Sean M. Lynn, James H. Naismith, Rebecca J. M. Goss, Freideriki Michailidou, Murray J. B. Brown
Publikováno v:
Angew Chem Int Ed Engl
The uridyl peptide antibiotics (UPAs), of which pacidamycin is a member, have a clinically unexploited mode of action and an unusual assembly. Perhaps the most striking feature of these molecules is the biosynthetically unique 3'-deoxyuridine that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41488c04e6c453c99ebd8b8ac1dc2e7
https://europepmc.org/articles/PMC8097591/
https://europepmc.org/articles/PMC8097591/