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In our search for endogenous natriuretic factors from human uremic urine, we have previously identified a new metabolite of the drug diltiazem (Murray et al. Life Sci. 1995, 57, 2145-2161). The structure of this metabolite, (+)-(2S,3S)-3-hydroxy-5-(2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae7eff437cd1a65051255b2f4853f86
https://doi.org/10.1021/jm950559n

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Has the elusive 'natriuretic factor' been discovered, and if so, is it a hormone?

Autor: Wechter Wj, Murray Ed

Publikováno v: Experimental nephrology. 6(6)

This review summarizes the interesting and significant papers reported at the International Conference on Natriuretic and Digitalis-like Factors held at the ASH meeting in San Francisco, June 1–2, 1997. This area of investigation has been rejuvenat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ec89e9a28bce71f8ea5d5064e5294c
https://pubmed.ncbi.nlm.nih.gov/9807018

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Natriuretic hormones II

Autor: Elaine J. Benaksas, William J. Wechter, Murray Ed

Publikováno v: Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques ISBN: 9783034871662

Renal sodium metabolism, an important determinant of blood pressure, is regulated with great precision by a variety of endocrine, autocrine, and neuronal factors. Although these factors regulate sodium metabolism by affecting the rate of tubular sodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ca7ab475cc913a5b589ebf9f08db610
https://doi.org/10.1007/978-3-0348-7164-8_7

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Rac-flurbiprofen is more ulcerogenic than its (S)-enantiomer

Autor: B. H. Levine, Young Jw, A. E. Bigornia, William J. Wechter, Murray Ed

Publikováno v: Chirality. 5(7)

The most common, and sometimes life-threatening, side-effects associated with the human use of the analgesic, nonsteroidal antiinflammatory drugs (NSAIDs) are gastrointestinal. These include gastritis, ulceration, and severe bleeding. The aryl propio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c806fd8b106e674038eae1a50f5d96b9
https://pubmed.ncbi.nlm.nih.gov/8240924

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