Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Murray B. Herd"'
Autor:
Vincent T. Cunliffe, Murray B. Herd, Marysia Placzek, John Paul Ashton, H. Steve White, Celia J. Holdsworth, Anthony G Marson, Melissa Barker-Haliski, Alan Morgan, Andrei S. Ilie, Jeremy J. Lambert, Graeme J. Sills, Andrew J. Trevelyan, Sarah Baxendale, Bodiabaduge A. P. Jayasekera, Christopher J. A. Cowie, Alistair Jones
Publikováno v:
Epilepsia
Objective Current medicines are ineffective in approximately one‐third of people with epilepsy. Therefore, new antiseizure drugs are urgently needed to address this problem of pharmacoresistance. However, traditional rodent seizure and epilepsy mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e340e800d0a79203c3dcb90722981e5
https://pubmed.ncbi.nlm.nih.gov/32797628
https://pubmed.ncbi.nlm.nih.gov/32797628
Autor:
Adam R. Brown, Scott J. Mitchell, Ben G. Gunn, Mohsen Seifi, Jerome D. Swinny, Delia Belelli, Grant D. Phillips, Jeremy J. Lambert, Murray B. Herd
Publikováno v:
Belelli, D, Brown, A R, Mitchell, S J, Gunn, B G, Herd, M B, Phillips, G D, Seifi, M, Swinny, J D & Lambert, J J 2018, ' Endogenous neurosteroids influence synaptic GABAA receptors during postnatal development ', Journal of Neuroendocrinology, vol. 30, no. 2 . https://doi.org/10.1111/jne.12537
Belelli, D, Brown, A R, Mitchell, S J, Gunn, B G, Herd, M B, Phillips, G, Seifi, M, Swinny, J D & Lambert, J J 2017, ' Endogenous neurosteroids influence synaptic GABA A receptors during post-natal development ', Journal of Neuroendocrinology . https://doi.org/10.1111/jne.12537
Belelli, D, Brown, A R, Mitchell, S J, Gunn, B G, Herd, M B, Phillips, G, Seifi, M, Swinny, J D & Lambert, J J 2017, ' Endogenous neurosteroids influence synaptic GABA A receptors during post-natal development ', Journal of Neuroendocrinology . https://doi.org/10.1111/jne.12537
GABA plays a key role in both embryonic and neonatal brain development. For example, during early neonatal nervous system maturation, synaptic transmission, mediated by GABAA receptors (GABAARs), undergoes a temporally specific form of synaptic plast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4be000505b4f0085cef7e527114d01
https://pure.solent.ac.uk/en/publications/4ac2e01d-9ebb-47a9-bd63-f845868bf5d4
https://pure.solent.ac.uk/en/publications/4ac2e01d-9ebb-47a9-bd63-f845868bf5d4
Publikováno v:
The Journal of Physiology. 593:267-284
Key points During neuronal development synaptic events mediated by GABAA receptors are progressively reduced in their duration, allowing for rapid and precise network function. Here we focused on ventrobasal thalamocortical neurones, which contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9fa938590cdf9ec91db683b3473c939
https://doi.org/10.1113/jphysiol.2014.280263
https://doi.org/10.1113/jphysiol.2014.280263
Publikováno v:
The European Journal of Neuroscience
Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf09b04af7a2090e7166c5f9a03d33e
http://europepmc.org/articles/PMC4215602
http://europepmc.org/articles/PMC4215602
Publikováno v:
The Journal of Neuroscience. 33:14850-14868
Thalamocortical circuits govern cognitive, sensorimotor, and sleep-related network processes, and generate pathological activities during absence epilepsy. Inhibitory control of thalamocortical (TC) relay neurons is partially mediated by GABA release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ec74c6d0299cdc1d6938dc08fbf8de
https://doi.org/10.1523/jneurosci.1174-13.2013
https://doi.org/10.1523/jneurosci.1174-13.2013
Publikováno v:
Neurochemistry International. 52:588-595
Over the past 20 years it has become apparent that certain steroids, synthesised de novo in the brain, hence named neurosteroids, produce immediate changes (within seconds) in neuronal excitability, a time scale that precludes a genomic locus of acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478cb4e8e07a5057778f157965070cfe
https://doi.org/10.1016/j.neuint.2007.10.007
https://doi.org/10.1016/j.neuint.2007.10.007
Autor:
Gregg E. Homanics, Murray B. Herd, Keith A. Wafford, Thomas W. Rosahl, Alison R. Haythornthwaite, Delia Belelli, Jeremy J. Lambert
Publikováno v:
The Journal of Physiology. 586:989-1004
The subunit composition of GABAA receptors influences their biophysical and pharmacological properties, dictates neuronal location and the interaction with associated proteins, and markedly influences the impact of intracellular biochemistry. The foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3041a478c67543bd8f65222b098c9da
https://doi.org/10.1113/jphysiol.2007.146746
https://doi.org/10.1113/jphysiol.2007.146746
Autor:
Jeremy J. Lambert, Murray B. Herd, Jean-Marc Fritschy, Keith A. Wafford, Delia Belelli, Murat S. Durakoglugil, Gregg E. Homanics, Thomas W. Rosahl, Caroline M. Petitjean, Dianne R. Peden
Publikováno v:
The Journal of Physiology. 586:965-987
Thalamic ventrobasal (VB) relay neurones express multiple GABA(A) receptor subtypes mediating phasic and tonic inhibition. During postnatal development, marked changes in subunit expression occur, presumably reflecting changes in functional propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f178a06cd502e145e41c8132f4892ac
https://doi.org/10.1113/jphysiol.2007.145375
https://doi.org/10.1113/jphysiol.2007.145375
Autor:
Jeremy J. Lambert, Jerome D. Swinny, Dianne R. Peden, Delia Belelli, Scott J. Mitchell, Mohsen Seifi, Adam R. Brown, Murray B. Herd
Publikováno v:
Neuropharmacology
Brown, A R, Mitchell, S J, Peden, D R, Herd, M B, Seifi, M, Swinny, J D, Belelli, D & Lambert, J J 2016, ' During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons ', Neuropharmacology, vol. 103, pp. 163-173 . https://doi.org/10.1016/j.neuropharm.2015.11.019
Brown, A R, Mitchell, S J, Peden, D R, Herd, M B, Seifi, M, Swinny, J D, Belelli, D & Lambert, J J 2016, ' During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons ', Neuropharmacology, vol. 103, pp. 163-173 . https://doi.org/10.1016/j.neuropharm.2015.11.019
As neuronal development progresses, GABAergic synaptic transmission undergoes a defined program of reconfiguration. For example, GABAA receptor (GABAAR)-mediated synaptic currents, (miniature inhibitory postsynaptic currents; mIPSCs), which initially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5f3ff5cfaa30110aed3df8a07e2584
https://pubmed.ncbi.nlm.nih.gov/26626485
https://pubmed.ncbi.nlm.nih.gov/26626485
Autor:
Audrey Vardy, Luc J. Gentet, Elizabeth A. Mitchell, Jeremy J. Lambert, Delia Belelli, Murray B. Herd, Dianne R. Peden
Publikováno v:
Neuroscience. 138:821-829
Dysfunction of GABA(A) receptor-mediated inhibition is implicated in a number of neurological and psychiatric conditions including epilepsy and affective disorders. Some of these conditions have been associated with abnormal levels of certain endogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0775bb2e88e2d6ec7393df12909888
https://doi.org/10.1016/j.neuroscience.2005.07.021
https://doi.org/10.1016/j.neuroscience.2005.07.021