Zobrazeno 1 - 10
of 761
pro vyhledávání: '"Murray, Stewart"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cellular proliferation, function and survival is reliant upon maintaining appropriate intracellular polyamine levels. Due to increased metabolic needs, cancer cells elevate their polyamine pools through coordinated metabolism and uptake. Hig
Externí odkaz:
https://doaj.org/article/fa46c4e9d60a406cbd62b256f2e5d9bd
Autor:
Xianzun Tao, Jiaqi Liu, Zoraida Diaz-Perez, Jackson R. Foley, Ashley Nwafor, Tracy Murray Stewart, Robert A. Casero, R. Grace Zhai
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-10 (2024)
Abstract Precise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder–Robinson intellectual disability syndrome (SRS), characterized by significant spermidine accumulation and autophagy
Externí odkaz:
https://doaj.org/article/df16f6f1f6604cb3868b67740e22aee2
Autor:
Oluwaseun Akinyele, Anushe Munir, Marie A. Johnson, Megan S. Perez, Yuan Gao, Jackson R. Foley, Ashley Nwafor, Yijen Wu, Tracy Murray-Stewart, Robert A. Casero, Hülya Bayir, Dwi U. Kemaladewi
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/97fb027069a74c2b824600638dca6afa
Autor:
Tracy Murray Stewart, Jackson R Foley, Cassandra E Holbert, Maxim Khomutov, Noushin Rastkari, Xianzun Tao, Alex R Khomutov, R Grace Zhai, Robert A Casero
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-11 (2023)
Abstract Snyder–Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis,
Externí odkaz:
https://doaj.org/article/5cc8bb3c21394af3a39b11fa46178f84
Autor:
Abdulkader Yassin-Kassab, Nathaniel Wang, Jackson Foley, Tracy Murray Stewart, Mark R. Burns, Robert A. Casero, Jr., R. Alex Harbison, Umamaheswar Duvvuri
Publikováno v:
Oral Oncology Reports, Vol 8, Iss , Pp 100123- (2023)
Background: Surgery and/or platinum-based chemoradiation remain standard of care for patients with head and neck squamous cell carcinoma (HNSCC). While these therapies are effective in a subset of patients, a substantial proportion experience recurre
Externí odkaz:
https://doaj.org/article/fa4cd743a30947f3b9126ba27820f186
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1157 (2024)
Polyamines are small polycationic alkylamines that are absolutely required for the continual growth and proliferation of cancer cells. The polyamine analogue ivospemin, also known as SBP-101, has shown efficacy in slowing pancreatic and ovarian tumor
Externí odkaz:
https://doaj.org/article/b4ab1d9f7cce4a9eae317db457078fbc
Autor:
Kamyar Zahedi, Sharon Barone, Marybeth Brooks, Tracy Murray Stewart, Jackson R. Foley, Ashley Nwafor, Robert A. Casero, Manoocher Soleimani
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 640 (2024)
Cisplatin, a chemotherapeutic agent, can cause nephrotoxic and ototoxic injuries. Using a mouse model of repeated low dose cisplatin (RLDC), we compared the kidneys of cisplatin- and vehicle-treated mice on days 3 (early injury phase) and 35 (late in
Externí odkaz:
https://doaj.org/article/c48f6db75b95420fbbfb46630f9bec28
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