Infant-derived human nasal organoids exhibit relatively increased susceptibility, epithelial responses, and cytotoxicity during RSV infection

Autor: Aloisio, Gina M., Nagaraj, Divya, Murray, Ashley M., Schultz, Emily M., McBride, Trevor, Aideyan, Letisha, Nicholson, Erin G., Henke, David, Ferlic-Stark, Laura, Rajan, Anubama, Kambal, Amal, Johnson, Hannah L., Mosa, Elina, Stossi, Fabio, Blutt, Sarah E., Piedra, Pedro A., Avadhanula, Vasanthi

Publikováno v: In Journal of Infection December 2024 89(6)

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Pediatric human nose organoids demonstrate greater susceptibility, epithelial responses, and cytotoxicity than adults during RSV infection.

Autor: Aloisio GM; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA., Nagaraj D; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Murray AM; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Schultz EM; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., McBride T; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Aideyan L; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Nicholson EG; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA., Henke D; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Ferlic-Stark L; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Rajan A; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Kambal A; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Johnson HL; Advanced Technology Cores, Baylor College of Medicine, Houston, Texas, USA., Mosa E; Advanced Technology Cores, Baylor College of Medicine, Houston, Texas, USA., Stossi F; Advanced Technology Cores, Baylor College of Medicine, Houston, Texas, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA., Blutt SE; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Piedra PA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA., Avadhanula V; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 01. Date of Electronic Publication: 2024 Feb 01.