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Systemic inhibition of de novo purine biosynthesis prevents weight gain and improves metabolic health by increasing thermogenesis and decreasing food intake.

Autor: Myers JW; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Park WY; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Eddie AM; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Shinde AB; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Prasad P; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA., Murphy AC; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA., Leonard MZ; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN, USA., Pinette JA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Rampy JJ; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT, USA., Montufar C; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Shaikh Z; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Hickman TT; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA., Reynolds GN; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Winn NC; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Lantier L; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Vanderbilt Mouse Metabolic Phenotyping Center, Nashville, TN, USA., Peck SH; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Coate KC; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Stein RW; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Carrasco N; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Calipari ES; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN, USA., McReynolds MR; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA., Zaganjor E; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Vanderbilt Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 01. Date of Electronic Publication: 2024 Nov 01.

Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts.

Autor: Vue Z; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Ajayi PT; Muscle Energetics Laboratory, NHLBI, NIH, Bethesda, MD, 20892, USA., Neikirk K; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Murphy AC; Department of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, State College, PA 16801., Prasad P; Department of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, State College, PA 16801., Jenkins BC; Department of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, State College, PA 16801., Vang L; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Garza-Lopez E; Department of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USA., Mungai M; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Marshall AG; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Beasley HK; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Killion M; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Parker R; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Anukodem J; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Lavine K; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Ajijola O; UCLA Cardiac Arrhythmia Center, University of California, Los Angeles, CA, USA., Mobley BC; Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, 37232 USA., Dai DF; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Exil V; Department of Pediatrics, Div. of Cardiology, St. Louis University School of Medicine, St. Louis, MO, 63104, USA., Kirabo A; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Su YR; Department of Medicine, Division of Infectious Diseases, Vanderbilt University, Nashville, TN, 37232, USA., Tomasek K; Department of Medicine, Division of Infectious Diseases, Vanderbilt University, Nashville, TN, 37232, USA., Zhang X; Department of Medicine, Division of Infectious Diseases, Vanderbilt University, Nashville, TN, 37232, USA., Wanjalla C; Department of Medicine, Division of Infectious Diseases, Vanderbilt University, Nashville, TN, 37232, USA., Hubert DL; Department of Integrative Biology, Oregon State University, Corvallis, OR, 97331, USA., Phillips MA; Department of Integrative Biology, Oregon State University, Corvallis, OR, 97331, USA., Shao JQ; Central Microscopy Research Facility, Iowa City, IA 52242, USA., McReynolds MR; Department of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, State College, PA 16801., Glancy B; Muscle Energetics Laboratory, NHLBI, NIH, Bethesda, MD, 20892, USA.; NIAMS, NIH, Bethesda, MD, 20892, USA., Hinton A Jr; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 14. Date of Electronic Publication: 2023 Dec 14.