Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Murni Tio"'
Autor:
Murni Tio, Rujing Wen, Cai Ning Choo, Jian Bin Tan, Aaron Chua, Bin Xiao, Jeyapriya Rajameenakshi Sundaram, Christine Hui Shan Chan, Eng-King Tan
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-23 (2024)
Abstract Background Mutations in CHCHD2 have been linked to Parkinson’s disease, however, their exact pathophysiologic roles are unclear. The p32 protein has been suggested to interact with CHCHD2, however, the physiological functions of such inter
Externí odkaz:
https://doaj.org/article/6b0c5e5c904f4378a64375f261a25084
Autor:
Yin Xia Chao, Ebonne Yu Lin Ng, Huihua Li, Kandiah Nagaendran, Yuen Yih, Mei Sian Chong, Kumar M. Prakash, Louis Tan, Wing Lok Au, Yi Zhao, Zhi Dong Zhou, Murni Tio, Ratnagopal Pavanni, Eng King Tan
Publikováno v:
Parkinson's Disease, Vol 2015 (2015)
Objective. COQ2 mutations have been reported in Japanese multiple system atrophy (MSA) patients. We examined the role of COQ2 in patients with dementia and essential tremor (ET), two common neurodegenerative conditions. Materials & Methods. A total o
Externí odkaz:
https://doaj.org/article/4b9cdc49ba1b441eba853a2dc0ddca30
Autor:
Lauren N. Miterko, Phyllis L. Faust, Martin J. Gallagher, Sheng-Han Kuo, Ming Kai Pan, Elan D. Louis, Murni Tio, Stefan M. Pulst, Su youne Chang, Adrian Handforth, Kyle A. Lyman, Billur Avlar, Roy V. Sillitoe, Dane M. Chetkovich, Eng-King Tan, Collin J. Anderson, Rodger J. Elble, Amanda M Brown, Lorraine N. Clark, Eric J. Lang
Publikováno v:
Cerebellum
Tremor is the most common movement disorder; however, we are just beginning to understand the brain circuitry that generates tremor. Various neuroimaging, neuropathological, and physiological studies in human tremor disorders have been performed to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9875072fd92889c60b34121078cfdc
https://doi.org/10.1007/s12311-019-01037-1
https://doi.org/10.1007/s12311-019-01037-1
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26879 (2011)
In Drosophila, dopaminergic (DA) neurons can be found from mid embryonic stages of development till adulthood. Despite their functional involvement in learning and memory, not much is known about the developmental as well as molecular mechanisms invo
Externí odkaz:
https://doaj.org/article/47d13f54e74b44b0911023b8ec8814ea
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9398 (2010)
Mesenchymal stem cells (MSCs) have multilineage differentiation potential which includes cell lineages of the central nervous system; hence MSCs might be useful in the treatment of neurodegenerative diseases such as Parkinson's disease. Although mese
Externí odkaz:
https://doaj.org/article/3c7a151fe0da4b07b1b7c618062b803a
Publikováno v:
Human Genetics
Essential tremor (ET) is one of the most common adult-onset neurological disorders which produce motor and non-motor symptoms. To date, there are no gold standard pathological hallmarks of ET, and despite a strong genetic contribution toward ET devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac658aba9e1e74750696d1940b4de311
https://doi.org/10.1007/s00439-016-1709-z
https://doi.org/10.1007/s00439-016-1709-z
Publikováno v:
Stem Cell Research. 18:48-50
Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 72-year old female Parkinson's disease (PD) patient with R1398H variant in the LRRK2 gene. The PMBCs were reprogrammed with the human OSKM transcription factors usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1aaab95de4a610e05495441e47742f6
Varied pathological and therapeutic response effects associated with CHCHD2 mutant and risk variants
Autor:
Yi Zhao, Zul Haikhel Bin Zukifli, Zhi Dong Zhou, Rujing Wen, Shaoping Xie, Patrick Ho, Tong Wey Koh, Eng-King Tan, Murni Tio, Yih Lin Lim
Publikováno v:
Human mutation. 38(8)
Mutations and polymorphic risk variant of coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) have been associated with late-onset Parkinson disease. In vivo pathological evidence of CHCHD2 mutations is currently lacking. Utilizing trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cc2b310d5a093ef7094356a4ffdc0d
https://pubmed.ncbi.nlm.nih.gov/28697279
https://pubmed.ncbi.nlm.nih.gov/28697279
Autor:
Murni Tio, Yuen Yih, Ebonne Yulin Ng, Wing Lok Au, Prakash M. Kumar, Louis C.S. Tan, Eng-King Tan, Yin Xia Chao
Publikováno v:
Parkinsonismrelated disorders. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7b772652bc97a0d651e49d3e86bcbf
https://pubmed.ncbi.nlm.nih.gov/27569844
https://pubmed.ncbi.nlm.nih.gov/27569844
Autor:
Wanru Fang, Rahul Pandey, Joanne Toh, William Chia, Murni Tio, Priyadarshini Rath, Gerhard M. Technau, Gerald Udolph
Publikováno v:
Developmental Biology. 336(2):156-168
The generation of cellular diversity in the nervous system involves the mechanism of asymmetric cell division. Besides an array of molecules, including the Par protein cassette, a heterotrimeric G protein signalling complex, Inscuteable plays a major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e060269fba2d78125cc07e67ae452de