Annual review of KRAS inhibitors in 2022.

Autor: Wang H; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China., Chi L; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China., Yu F; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China., Dai H; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China., Gao C; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China., Si X; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China., Wang Z; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China., Liu L; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China., Zheng J; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China., Shan L; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China. Electronic address: shlh@zzu.edu.cn., Liu H; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou, 450052, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou, 450001, China. Electronic address: liuhm@zzu.edu.cn., Zhang Q; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou, 450001, China. Electronic address: zqr409@yeah.net.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Mar 05; Vol. 249, pp. 115124. Date of Electronic Publication: 2023 Jan 16.

Wild‑type KRAS inhibits the migration and invasion of pancreatic cancer through the Wnt/β‑catenin pathway.

Autor: Hu X; Department of Medical Laboratory, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China., Zhang R; School of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China., Yao J; School of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China., Mu B; School of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China., Zhao C; Sichuan Key Laboratory of Medical Imaging, Institute of Medical Imaging, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.

Publikováno v: Molecular medicine reports [Mol Med Rep] 2023 Jan; Vol. 27 (1). Date of Electronic Publication: 2022 Nov 11.

Pan-KRAS inhibitors suppress proliferation through feedback regulation in pancreatic ductal adenocarcinoma.

Autor: Wang CX; State Key Laboratory of Oncogenes and Related Genes, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China., Wang TT; Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China., Zhang KD; Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China., Li MY; State Key Laboratory of Oncogenes and Related Genes, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China., Shen QC; Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China., Lu SY; State Key Laboratory of Oncogenes and Related Genes, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China. lushaoyong@sjtu.edu.cn.; Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China. lushaoyong@sjtu.edu.cn., Zhang J; State Key Laboratory of Oncogenes and Related Genes, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China. jian.zhang@sjtu.edu.cn.; Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China. jian.zhang@sjtu.edu.cn.; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. jian.zhang@sjtu.edu.cn.

Publikováno v: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2022 Oct; Vol. 43 (10), pp. 2696-2708. Date of Electronic Publication: 2022 Mar 29.

KRAS mutations as essential promoters of lymphangiogenesis via extracellular vesicles in pancreatic cancer.

Autor: Pirlog R; Research Center for Functional Genomics Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.; Department of Translational Molecular Pathology, Division of Pathology, and., Calin GA; Department of Translational Molecular Pathology, Division of Pathology, and.; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Jul 15; Vol. 132 (14).

Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast Reprogramming.

Autor: Velez-Delgado A; Department of Cell and Developmental Biology, Ann Arbor, Michigan., Donahue KL; Cancer Biology Program, Ann Arbor, Michigan., Brown KL; Department of Surgery, Ann Arbor, Michigan., Du W; Department of Surgery, Ann Arbor, Michigan., Irizarry-Negron V; Department of Surgery, Ann Arbor, Michigan., Menjivar RE; Cellular and Molecular Biology Program, Ann Arbor, Michigan., Lasse Opsahl EL; Cancer Biology Program, Ann Arbor, Michigan., Steele NG; Department of Cell and Developmental Biology, Ann Arbor, Michigan., The S; Department of Computational Medicine and Bioinformatics, Ann Arbor, Michigan., Lazarus J; Department of Surgery, Ann Arbor, Michigan., Sirihorachai VR; Cancer Biology Program, Ann Arbor, Michigan., Yan W; Department of Surgery, Ann Arbor, Michigan., Kemp SB; Molecular and Cellular Pathology Program, Ann Arbor, Michigan., Kerk SA; Cancer Biology Program, Ann Arbor, Michigan., Bollampally M; Life Sciences and Arts College, Ann Arbor, Michigan., Yang S; Life Sciences and Arts College, Ann Arbor, Michigan., Scales MK; Department of Cell and Developmental Biology, Ann Arbor, Michigan., Avritt FR; Life Sciences and Arts College, Ann Arbor, Michigan., Lima F; Department of Surgery, Ann Arbor, Michigan., Lyssiotis CA; Cancer Biology Program, Ann Arbor, Michigan; Department of Molecular and Integrative Physiology, Ann Arbor, Michigan; Rogel Cancer Center, Ann Arbor, Michigan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ann Arbor, Michigan., Rao A; Cancer Biology Program, Ann Arbor, Michigan; Department of Computational Medicine and Bioinformatics, Ann Arbor, Michigan; Rogel Cancer Center, Ann Arbor, Michigan; Michigan Institute of Data Science, Ann Arbor, Michigan; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan., Crawford HC; Cancer Biology Program, Ann Arbor, Michigan; Department of Molecular and Integrative Physiology, Ann Arbor, Michigan; Rogel Cancer Center, Ann Arbor, Michigan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ann Arbor, Michigan., Bednar F; Department of Surgery, Ann Arbor, Michigan; Rogel Cancer Center, Ann Arbor, Michigan., Frankel TL; Department of Surgery, Ann Arbor, Michigan; Rogel Cancer Center, Ann Arbor, Michigan., Allen BL; Department of Cell and Developmental Biology, Ann Arbor, Michigan., Zhang Y; Department of Surgery, Ann Arbor, Michigan; Rogel Cancer Center, Ann Arbor, Michigan. Electronic address: yaqingzh@umich.edu., Pasca di Magliano M; Department of Cell and Developmental Biology, Ann Arbor, Michigan; Cancer Biology Program, Ann Arbor, Michigan; Department of Surgery, Ann Arbor, Michigan; Cellular and Molecular Biology Program, Ann Arbor, Michigan; Rogel Cancer Center, Ann Arbor, Michigan. Electronic address: marinapa@umich.edu.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2022; Vol. 13 (6), pp. 1673-1699. Date of Electronic Publication: 2022 Mar 01.