Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors.

Autor: Beetham H; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Griffith BGC; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Murina O; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Loftus AEP; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Parry DA; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Temps C; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Culley J; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Muir M; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Unciti-Broceta A; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Sims AH; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Byron A; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom., Brunton VG; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, United Kingdom.

Publikováno v: Cancer research [Cancer Res] 2022 Feb 15; Vol. 82 (4), pp. 632-647.

Elucidating the power of arginine restriction: taming type I interferon response in breast cancer via selective autophagy.

Autor: Lamsal, Apsana^1,2 (AUTHOR), Andersen, Sonja Benedikte^1,2 (AUTHOR), Johansson, Ida^1,2 (AUTHOR), Desgarnier, Marie-Catherine Drigeard^3,4 (AUTHOR), Wolowczyk, Camilla^1,2 (AUTHOR), Engedal, Nikolai⁵ (AUTHOR), Vietri, Marina^3,4 (AUTHOR), Bjørkøy, Geir^1,2 (AUTHOR), Giambelluca, Miriam S.^6,7 (AUTHOR) miriam.giambelluca@ntnu.no, Pettersen, Kristine^1,2 (AUTHOR) kristine.pettersen@ntnu.no

Publikováno v: Cell Communication & Signaling. 10/11/2024, Vol. 22 Issue 1, p1-15. 15p.

PRIM1 deficiency causes a distinctive primordial dwarfism syndrome.

Autor: Parry DA; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh, Edinburgh EH4 2XU, United Kingdom., Tamayo-Orrego L; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh, Edinburgh EH4 2XU, United Kingdom., Carroll P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh, Edinburgh EH4 2XU, United Kingdom., Marsh JA; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh, Edinburgh EH4 2XU, United Kingdom., Greene P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh, Edinburgh EH4 2XU, United Kingdom., Murina O; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh, Edinburgh EH4 2XU, United Kingdom., Uggenti C; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh, Edinburgh EH4 2XU, United Kingdom., Leitch A; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh, Edinburgh EH4 2XU, United Kingdom., Káposzta R; Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen H-4032, Hungary., Merő G; Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen H-4032, Hungary., Nagy A; Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen H-4032, Hungary., Orlik B; Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen H-4032, Hungary., Kovács-Pászthy B; Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen H-4032, Hungary., Quigley AJ; Department of Radiology, Royal Hospital for Sick Children, Edinburgh EH9 1LF, United Kingdom., Riszter M; Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen H-4032, Hungary., Rankin J; Department Clinical Genetics, Royal Devon and Exeter NHS Foundation Trust, Exeter EX1 2ED, United Kingdom., Reijns MAM; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh, Edinburgh EH4 2XU, United Kingdom., Szakszon K; Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen H-4032, Hungary., Jackson AP; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.

Publikováno v: Genes & development [Genes Dev] 2020 Nov 01; Vol. 34 (21-22), pp. 1520-1533. Date of Electronic Publication: 2020 Oct 15.

Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors.

Autor: Zhu, Yingjie^1,2 (AUTHOR), Pei, Xin² (AUTHOR), Novaj, Ardijana² (AUTHOR), Setton, Jeremy² (AUTHOR), Bronder, Daniel³ (AUTHOR), Derakhshan, Fatemeh^1,4 (AUTHOR), Selenica, Pier¹ (AUTHOR), McDermott, Niamh² (AUTHOR), Orman, Mehmet² (AUTHOR), Plum, Sarina³ (AUTHOR), Subramanyan, Shyamal² (AUTHOR), Braverman, Sara H.² (AUTHOR), McMillan, Biko² (AUTHOR), Sinha, Sonali² (AUTHOR), Ma, Jennifer² (AUTHOR), Gazzo, Andrea¹ (AUTHOR), Khan, Atif² (AUTHOR), Bakhoum, Samuel^2,3 (AUTHOR), Powell, Simon N.² (AUTHOR), Reis-Filho, Jorge S.¹ (AUTHOR) jsreis@hotmail.com

Publikováno v: Genome Medicine. 8/28/2024, Vol. 16 Issue 1, p1-17. 17p.

A retrospective study on the impact of radiotherapy on the survival outcomes of small cell lung cancer patients based on the SEER database.

Autor: Chen, Yao^1,2 (AUTHOR), Yao, Ling³ (AUTHOR), Chen, Qingquan² (AUTHOR), Hu, Yiming⁴ (AUTHOR), Zhu, Xi² (AUTHOR), Dai, Rongrong² (AUTHOR), Chen, Xiaoyang¹ (AUTHOR), Zeng, Yifu^1,5 (AUTHOR), Zhu, Yong⁶ (AUTHOR), Song, Duanhong¹ (AUTHOR) duanhong_S@126.com, Zhang, Yixiang¹ (AUTHOR) zhangyixiang@fjmu.edu.cn

Publikováno v: Scientific Reports. 7/5/2024, Vol. 14 Issue 1, p1-15. 15p.