Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Murilo S. Amaral"'
Autor:
Daisy Woellner-Santos, Ana C. Tahira, João V. M. Malvezzi, Vinicius Mesel, David A. Morales-Vicente, Monalisa M. Trentini, Lázaro M. Marques-Neto, Isaac A. Matos, Alex I. Kanno, Adriana S. A. Pereira, André A. R. Teixeira, Ricardo J. Giordano, Luciana C. C. Leite, Carlos A. B. Pereira, Ricardo DeMarco, Murilo S. Amaral, Sergio Verjovski-Almeida
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-19 (2024)
Abstract Schistosomiasis, a challenging neglected tropical disease, affects millions of people worldwide. Developing a prophylactic vaccine against Schistosoma mansoni has been hindered by the parasite’s biological complexity. In this study, we uti
Externí odkaz:
https://doaj.org/article/3538479b2fca4d06b0fefa7e31cf9fdf
Autor:
David A. Morales-Vicente, Lu Zhao, Gilbert O. Silveira, Ana C. Tahira, Murilo S. Amaral, James J. Collins, Sergio Verjovski-Almeida
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Schistosoma mansoni is a flatworm that causes schistosomiasis, a neglected tropical disease that affects over 200 million people worldwide. New therapeutic targets are needed with only one drug available for treatment and no vaccine. Long non-coding
Externí odkaz:
https://doaj.org/article/eb6cbefa830a40d781f8371bbaea9b7a
Autor:
Gilbert O. Silveira, Murilo S. Amaral, Helena S. Coelho, Lucas F. Maciel, Adriana S. A. Pereira, Giovanna G. O. Olberg, Patricia A. Miyasato, Eliana Nakano, Sergio Verjovski-Almeida
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is the most used, fast, and reproducible method to confirm large-scale gene expression data. The use of stable reference genes for the normalization of RT-qPCR
Externí odkaz:
https://doaj.org/article/e3e22ccbe69e4880829662ea5ea2957f
Autor:
Murilo S. Amaral, Lucas F. Maciel, Gilbert O. Silveira, Giovanna G. O. Olberg, João V. P. Leite, Lucas K. Imamura, Adriana S. A. Pereira, Patricia A. Miyasato, Eliana Nakano, Sergio Verjovski-Almeida
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Schistosoma mansoni is a flatworm that causes schistosomiasis, a neglected tropical disease that affects more than 200 million people worldwide. There is only one drug indicated for treatment, praziquantel, which may lead to parasite resista
Externí odkaz:
https://doaj.org/article/d5c3edb898084192917b2e847a1a6d94
Autor:
Jessica Lobo-Silva, Fernanda J. Cabral, Murilo S. Amaral, Patrícia A. Miyasato, Rafaela Paula de Freitas, Adriana S. A. Pereira, Mariana I. Khouri, Mayra M. F. Barbosa, Pablo I. P. Ramos, Luciana C. C. Leite, Oluwatoyin A. Asojo, Eliana Nakano, Sergio Verjovski-Almeida, Leonardo P. Farias
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-16 (2020)
Abstract Background Schistosomiasis chemotherapy is largely based on praziquantel (PZQ). Although PZQ is very safe and tolerable, it does not prevent reinfection and emerging resistance is a primary concern. Recent studies have shown that the targeti
Externí odkaz:
https://doaj.org/article/b28fc045da46440890e0a7293e0916e7
Autor:
Lucas F. Maciel, David A. Morales-Vicente, Gilbert O. Silveira, Raphael O. Ribeiro, Giovanna G. O. Olberg, David S. Pires, Murilo S. Amaral, Sergio Verjovski-Almeida
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Long non-coding RNAs (lncRNAs) (>200 nt) are expressed at levels lower than those of the protein-coding mRNAs, and in all eukaryotic model species where they have been characterized, they are transcribed from thousands of different genomic loci. In h
Externí odkaz:
https://doaj.org/article/bbca93ee3df2402997d3f28d77786e7e
Autor:
Lucas F. daSilva, Felipe C. Beckedorff, Ana C. Ayupe, Murilo S. Amaral, Vinícius Mesel, Alexandre Videira, Eduardo M. Reis, João C. Setubal, Sergio Verjovski-Almeida
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Cell signaling events triggered by androgen hormone in prostate cells is dependent on activation of the androgen receptor (AR) transcription factor. Androgen hormone binding to AR promotes its displacement from the cytoplasm to the nucleus and AR bin
Externí odkaz:
https://doaj.org/article/b0acb982f933435783967a0aa8f18fcd
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Long non-coding RNAs (lncRNAs) emerged in the past 20 years due to massive amounts of scientific data regarding transcriptomic analyses. They have been implicated in a plethora of cellular processes in higher eukaryotes. However, little is known abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024a11e5340a809fae6fc04d80d04add
https://doi.org/10.1007/s00436-021-07384-5
https://doi.org/10.1007/s00436-021-07384-5
Autor:
Gilbert O. Silveira, Helena S. Coelho, Adriana S. A. Pereira, Patrícia A. Miyasato, Daisy W. Santos, Lucas F. Maciel, Giovanna G. G. Olberg, Ana C. Tahira, Eliana Nakano, Maria Leonor S. Oliveira, Murilo S. Amaral, Sergio Verjovski-Almeida
Publikováno v:
PLOS Pathogens. 19:e1011369
The trematode parasite Schistosoma mansoni causes schistosomiasis, which affects over 200 million people worldwide. Schistosomes are dioecious, with egg laying depending on the females’ obligatory pairing with males. Long non-coding RNAs (lncRNAs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62f2972fb753ab135c7df99eb99b3ad9
https://doi.org/10.1371/journal.ppat.1011369
https://doi.org/10.1371/journal.ppat.1011369
Autor:
Danyllo Oliveira, Livia Luz, Felipe de Souza Leite, Carolini Kaid, Oswaldo Keith Okamoto, Mayana Zatz, Uirá Souto Melo, Thalita Figueiredo, Luiz Carlos de Caires, Andréa L. Sertié, Sergio Verjovski-Almeida, Ernesto Goulart, Murilo S. Amaral, David A. Morales-Vicente, Miguel Mitne-Neto, Claudia D. C. Navarro, Joyce Esposito, Luciana M Alves
Publikováno v:
Human Molecular Genetics. 29:1465-1475
Amyotrophic lateral sclerosis type 8 (ALS8) is an autosomal dominant form of ALS, which is caused by pathogenic variants in the VAPB gene. Here we investigated five ALS8 patients, classified as ‘severe’ and ‘mild’ from a gigantic Brazilian ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f507f86e85a31ca63d6eca9bd4a055
https://doi.org/10.1093/hmg/ddaa069
https://doi.org/10.1093/hmg/ddaa069