Long non-coding RNAs are essential for Schistosoma mansoni pairing-dependent adult worm homeostasis and fertility.

Autor: Gilbert O Silveira, Helena S Coelho, Adriana S A Pereira, Patrícia A Miyasato, Daisy W Santos, Lucas F Maciel, Giovanna G G Olberg, Ana C Tahira, Eliana Nakano, Maria Leonor S Oliveira, Murilo S Amaral, Sergio Verjovski-Almeida

Publikováno v: PLoS Pathogens, Vol 19, Iss 5, p e1011369 (2023)

The trematode parasite Schistosoma mansoni causes schistosomiasis, which affects over 200 million people worldwide. Schistosomes are dioecious, with egg laying depending on the females' obligatory pairing with males. Long non-coding RNAs (lncRNAs) ar

Externí odkaz: https://doaj.org/article/cbe44d662e964f55a99e953fb09f94cc

Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism.

Autor: Adriana S A Pereira, Murilo S Amaral, Elton J R Vasconcelos, David S Pires, Huma Asif, Lucas F daSilva, David A Morales-Vicente, Vitor C Carneiro, Claudia B Angeli, Giuseppe Palmisano, Marcelo R Fantappie, Raymond J Pierce, João C Setubal, Sergio Verjovski-Almeida

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006873 (2018)

BACKGROUND:The possibility of emergence of praziquantel-resistant Schistosoma parasites and the lack of other effective drugs demand the discovery of new schistosomicidal agents. In this context the study of compounds that target histone-modifying en

Externí odkaz: https://doaj.org/article/3fd93080721c4521b0f7d53c1dfc4fc9

The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation.

Autor: Felipe C Beckedorff, Ana C Ayupe, Renan Crocci-Souza, Murilo S Amaral, Helder I Nakaya, Daniela T Soltys, Carlos F M Menck, Eduardo M Reis, Sergio Verjovski-Almeida

Publikováno v: PLoS Genetics, Vol 9, Iss 8, p e1003705 (2013)

The down-regulation of the tumor-suppressor gene RASSF1A has been shown to increase cell proliferation in several tumors. RASSF1A expression is regulated through epigenetic events involving the polycomb repressive complex 2 (PRC2); however, the molec

Externí odkaz: https://doaj.org/article/ec6e8151289d4678a4989b51ca3aa8c0

Single-cell RNA-seq analyses show that long non-coding RNAs are conspicuously expressed in Schistosoma mansoni gamete and tegument progenitor cell populations

Autor: David A. Morales-Vicente, Lu Zhao, Gilbert O. Silveira, Ana C. Tahira, Murilo S. Amaral, James J. Collins, Sergio Verjovski-Almeida

Publikováno v: Frontiers in Genetics. 13

Schistosoma mansoni is a flatworm that causes schistosomiasis, a neglected tropical disease that affects over 200 million people worldwide. New therapeutic targets are needed with only one drug available for treatment and no vaccine. Long non-coding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05c944ff3f738d4f3a0b01de7d174857
https://doi.org/10.3389/fgene.2022.924877

Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge

Autor: Adriana S. A. Pereira, Claudia J. de Dood, Rafaela de Paula Freitas, Murilo S. Amaral, Ronaldo de Carvalho Augusto, Patricia A. Miyasato, Jorge Kalil, Vânia Gomes de Moura Mattaraia, Christoph Grunau, R. Alan Wilson, Simone de Oliveira Castro, Paul L. A. M. Corstjens, Daisy Woellner Santos, Elisa M. Tjon Kon Fat, Sergio Verjovski-Almeida, Eliana Nakano, Govert J. van Dam, Ana Carolina Tahira, João V M Malvezzi

Publikováno v: Nature Communications (2041-1723) (Springer Science and Business Media LLC), 2021-10, Vol. 12, N. 1, P. 6181 (17p.)
Nature Communications
Nature Communications, 2021, 12, ⟨10.1038/s41467-021-26497-0⟩
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Nature Publishing Group, 2021, 12, ⟨10.1038/s41467-021-26497-0⟩

The rhesus macaque provides a unique model of acquired immunity against schistosomes, which afflict >200 million people worldwide. By monitoring bloodstream levels of parasite-gut-derived antigen, we show that from week 10 onwards an established infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890e5c6865a2b7a029eef2cff88334a1
https://archimer.ifremer.fr/doc/00731/84272/