Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

Autor: Tohru Takaki, Marco Montagner, Murielle P. Serres, Maël Le Berre, Matt Russell, Lucy Collinson, Karoly Szuhai, Michael Howell, Simon J. Boulton, Erik Sahai, Mark Petronczki

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelo

Externí odkaz: https://doaj.org/article/662201e58c214629a0a38d3d261be1d7

p27Kip1 regulates the microtubule bundling activity of PRC1

Autor: Renaud T. Perchey, Murielle P. Serres, Ada Nowosad, Justine Creff, Caroline Callot, Alexandre Gay, Stéphane Manenti, Robert L. Margolis, Anastassia Hatzoglou, Arnaud Besson

Publikováno v: Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2018, 1865 (11), pp.1630-1639. ⟨10.1016/j.bbamcr.2018.08.010⟩
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2018, 1865 (11), pp.1630-1639. ⟨10.1016/j.bbamcr.2018.08.010⟩

International audience; Cytokinesis begins in anaphase with the formation of the central spindle. PRC1 is a microtubule associated protein that plays an essential role in central spindle formation by crosslinking antiparallel microtubules. We have id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307cb1055912caf0bbedee5c37cab2ae
https://doi.org/10.1016/j.bbamcr.2018.08.010

Cytoplasmic p27

Autor: Olivier, Calvayrac, Ada, Nowosad, Stéphanie, Cabantous, Lin-Po, Lin, Sarah, Figarol, Pauline, Jeannot, Murielle P, Serres, Caroline, Callot, Renaud T, Perchey, Justine, Creff, Estelle, Taranchon-Clermont, Isabelle, Rouquette, Gilles, Favre, Anne, Pradines, Stephane, Manenti, Julien, Mazieres, Huei, Lee, Arnaud, Besson

Publikováno v: The Journal of Pathology

Lung cancer is the leading cause of cancer mortality worldwide, with adenocarcinomas of the non‐small cell lung carcinoma (NSCLC) subtype accounting for the majority of cases. Therefore, an urgent need exists for a more detailed dissection of the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56c190b9e6b3418cb39d269d7b7b62c0
https://pubmed.ncbi.nlm.nih.gov/30549261

p27Kip1 controls cytokinesis via the regulation of citron kinase activation

Autor: Murielle P. Serres, Uta Kossatz, Arnaud Besson, James M. Roberts, Nisar P. Malek, Yong Chi

Publikováno v: Journal of Clinical Investigation. 122:844-858

p27(Kip1) (p27) acts as a tumor suppressor by inhibiting cyclin-cyclin-dependent kinase (cyclin-CDK) activity. However, mice expressing a form of p27 that is unable to bind or inhibit cyclin-CDK complexes (p27(CK-)) have increased incidence of tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9b0442988ece77ae138482941a7e67
https://doi.org/10.1172/jci60376

Rôle majeur pour p27 dans l’activité anti-tumorale d’un inhibiteur du protéasome

Autor: Arnaud Besson, Murielle P. Serres

Publikováno v: médecine/sciences. 25:213-214

leur exposition a l’argyrin A. En revanche, cet effet necessite l’activation de la caspase-3. Ces resultats se verifient egalement in vivo dans un modele de xenogreffe de cellules de carcinome du colon dans le flanc de souris. Lorsque ces animaux

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66c2ef3612ae5163b850c5063b029278
https://doi.org/10.1051/medsci/2009253213