Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Murielle M Véniant"'
Autor:
Marina Stolina, Xin Luo, Denise Dwyer, Chun-Ya Han, Rhonda Chen, Ying Zhang, YuMei Xiong, Yinhong Chen, Jun Yin, Artem Shkumatov, Brandon Ason, Clarence Hale, Murielle M Véniant
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0231234 (2020)
Cardiometabolic syndrome has become a global health issue. Heart failure is a common comorbidity of cardiometabolic syndrome. Successful drug development to prevent cardiometabolic syndrome and associated comorbidities requires preclinical models pre
Externí odkaz:
https://doaj.org/article/2a28d72dc487472ba9726d8fb014b07f
Autor:
Hongfei Ge, Jonitha Gardner, Xiaosu Wu, Ingrid Rulifson, Jinghong Wang, Yumei Xiong, Jingjing Ye, Edward Belouski, Ping Cao, Jie Tang, Ki Jeong Lee, Suzanne Coberly, Xinle Wu, Jamila Gupte, Lynn Miao, Li Yang, Natalie Nguyen, Bei Shan, Wen-Chen Yeh, Murielle M Véniant, Yang Li, Helene Baribault
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0126924 (2015)
Trefoil factor 3 (TFF3), also called intestinal trefoil factor or Itf, is a 59 amino acid peptide found as a homodimer predominantly along the gastrointestinal tract and in serum. TFF3 expression is elevated during gastrointestinal adenoma progressio
Externí odkaz:
https://doaj.org/article/80d053555e6a4ed7aa6585d3c09320bb
Autor:
Min Lu, Pingping Li, Gautam Bandyopadhyay, William Lagakos, Walter E Dewolf, Taylor Alford, Mark Joseph Chicarelli, Lance Williams, Deborah A Anderson, Brian R Baer, Maralee McVean, Marion Conn, Murielle M Véniant, Peter Coward
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88431 (2014)
Glucokinase (GK) is a hexokinase isozyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate. Glucokinase activators are being investigated as potential diabetes therapies because of their effects on hepatic glucose output and/or ins
Externí odkaz:
https://doaj.org/article/6b5ff3c689ce4246a24878968b2d01da
Autor:
Richard Smith, Amy Duguay, Alice Bakker, Peng Li, Jennifer Weiszmann, Melissa R Thomas, Benjamin M Alba, Xinle Wu, Jamila Gupte, Li Yang, Jennitte Stevens, Agnes Hamburger, Stephen Smith, Jiyun Chen, Renee Komorowski, Kevin W Moore, Murielle M Véniant, Yang Li
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61432 (2013)
The endocrine hormone FGF21 has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to the native cytokine, we generated bispecific Avimer polypeptides that bind with high affinity and speci
Externí odkaz:
https://doaj.org/article/94370a4c5af3418bafae3672e5e4eb24
Autor:
Randy Hecht, Yue-Sheng Li, Jeonghoon Sun, Ed Belouski, Michael Hall, Todd Hager, Junming Yie, Wei Wang, Dwight Winters, Stephen Smith, Chris Spahr, Lei-Ting Tam, Zhongnan Shen, Shanaka Stanislaus, Narumol Chinookoswong, Yvonne Lau, Allen Sickmier, Mark Leo Michaels, Thomas Boone, Murielle M Véniant, Jing Xu
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49345 (2012)
Fibroblast growth factor 21 (FGF21) is a promising drug candidate for the treatment of type 2 diabetes. However, the use of wild type native FGF21 is challenging due to several limitations. Among these are its short half-life, its susceptibility to i
Externí odkaz:
https://doaj.org/article/4b03784bd0594b29a2d0316fd49362ba
Autor:
Murielle M Véniant, Clarence Hale, Joan Helmering, Michelle M Chen, Shanaka Stanislaus, Jim Busby, Steven Vonderfecht, Jing Xu, David J Lloyd
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40164 (2012)
Fibroblast growth factor 21 (FGF21) is a potent metabolic regulator, and pharmacological administration elicits glucose and lipid lowering responses in mammals. To delineate if adipose tissue is the predominant organ responsible for anti-diabetic eff
Externí odkaz:
https://doaj.org/article/da87ceebbe5b427fb5ea0d3269c57f7b
A volumetric method for quantifying atherosclerosis in mice by using microCT: comparison to en face.
Autor:
David J Lloyd, Joan Helmering, Stephen A Kaufman, James Turk, Matt Silva, Sergio Vasquez, David Weinstein, Brad Johnston, Clarence Hale, Murielle M Véniant
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18800 (2011)
Precise quantification of atherosclerotic plaque in preclinical models of atherosclerosis requires the volumetric assessment of the lesion(s) while maintaining in situ architecture. Here we use micro-computed tomography (microCT) to detect ex vivo ao
Externí odkaz:
https://doaj.org/article/ae7f2e2eb1cd43f9a5a2073955438af5
Autor:
Jennifer L. Strande, Vamsi Kurra, Rohini Jeswani, Rajneet Oberoi, Lucie Sharpsten, Joel Neutel, Murielle M. Véniant, Jane R. Parnes
Publikováno v:
Metabolism. 142:155433
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1764-1775 (2020)
J Lipid Res
J Lipid Res
Of the known regulators of atherosclerosis, miRNAs have been demonstrated to play critical roles in lipoprotein homeostasis and plaque formation. Here, we generated a novel animal model of atherosclerosis by knocking in LDLR(W483X) in C57BL/6 mice, a
Autor:
Elizabeth A. Killion, Rajaa Hussien, Artem Shkumatov, Rhian Davies, David J. Lloyd, Murielle M. Véniant, Herve Lebrec, Madeline M. Fort
Publikováno v:
AndrologyREFERENCES. 10(4)
Glucose-dependent insulinotropic polypeptide receptor (Gipr) gene expression has been reported in mouse spermatids and Gipr knockout male mice have previously been reported to have decreased in vitro fertilization, although the role of Gipr signaling