Výsledky vyhledávání - "Muriel Soler"

Virological Effects of Isis 14803, An Antisense Oligonucleotide Inhibitor of Hepatitis C Virus (HCV) Internal Ribosome Entry Site (IRES), on HCV Ires in Chronic Hepatitis C Patients and Examination of the Potential Role of Primary and Secondary HCV Resistance in the Outcome of Treatment

Autor: T. Jesse Kwoh, Muriel Soler, John G. McHutchison, Jean-Michel Pawlotsky, F. Andrew Dorr

Publikováno v: Antiviral Therapy. 9:953-968

Antisense oligonucleotides represent a promising class of antiviral agents. ISIS 14803 is a 20-unit phosphorothioate oligodeoxynucleotide that inhibited hepatitis C virus (HCV) replication and protein expression in cell culture and mouse models. A Ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b254d700156d6d0d0a505c52f4f27c2
https://doi.org/10.1177/135965350400900612

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Virological effects of ISIS 14803, an antisense oligonucleotide inhibitor of hepatitis C virus (HCV) internal ribosome entry site (IRES), on HCV IRES in chronic hepatitis C patients and examination of the potential role of primary and secondary HCV resistance in the outcome of treatment

Autor: Muriel, Soler, John G, McHutchison, T Jesse, Kwoh, F Andrew, Dorr, Jean-Michel, Pawlotsky

Publikováno v: Antiviral therapy. 9(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b344a6f78d8c4267e230e7b06eb960b8
https://pubmed.ncbi.nlm.nih.gov/15651754

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HCV resistance to ISIS 14803, an antisense oligonucleotide inhibitor of HCV. Effect of target region sequence on antiviral efficacy

Autor: Jean-Michel Pawlotsky, F.A. Dorr, T.J. Kwoh, John G. McHutchison, Muriel Soler

Publikováno v: Journal of Hepatology. 38:18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b55a91ee8276c78f0d0bb6d037326434
https://doi.org/10.1016/s0168-8278(03)80465-8

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Hepatitis C virus NS3 serine protease variability and evolution are strongly constrained by the need for structural and functional conservation

Autor: Jean-Michel Pawlotsky, François Penin, Stuart Ray, Muriel Soler, Daniel Dhumeaux

Publikováno v: Journal of Hepatology. 36:5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::623ba73d286ca392d555c631c3480699
https://doi.org/10.1016/s0168-8278(02)80007-1

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Quasispecies Heterogeneity and Constraints on the Evolution of the 5′ Noncoding Region of Hepatitis C Virus (HCV): Relationship with HCV Resistance to Interferon-α Therapy

Autor: Muriel Pellerin, Daniel Dhumeaux, Jean-Michel Pawlotsky, Cécile E. Malnou, Katherine M. Kean, Muriel Soler

Publikováno v: Virology. (1):160-173

Hepatitis C virus (HCV) polyprotein translation depends on direct internal entry of the 40S ribosomal subunit mediated by an internal ribosome entry segment (IRES) located in the 5′ noncoding (5′NC) region of the viral genome. HCV is genetically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80db720032eab55d52d00da602713e4

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