Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Muriel Nobles"'
Autor:
Dorota Zawada, Jessica Kornherr, Anna B. Meier, Gianluca Santamaria, Tatjana Dorn, Monika Nowak-Imialek, Daniel Ortmann, Fangfang Zhang, Mark Lachmann, Martina Dreßen, Mariaestela Ortiz, Victoria L. Mascetti, Stephen C. Harmer, Muriel Nobles, Andrew Tinker, Maria Teresa De Angelis, Roger A. Pedersen, Phillip Grote, Karl-Ludwig Laugwitz, Alessandra Moretti, Alexander Goedel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The heart is formed from several spatiotemporally distinct progenitor pools during development. Here they show that modulation of retinoic acid signaling can instruct human pluripotent stems cells into heart progenitors that are useful for studying h
Externí odkaz:
https://doaj.org/article/10a747d5fcc140e6a38c4095415e2a1f
Publikováno v:
Bio-Protocol, Vol 10, Iss 1 (2020)
The cardiac conduction system allows the synchronized propagation of electrical activity through heart muscle. This is initiated by the spontaneous activity of the specialized pacemaker cells of the sino-atrial node (SAN). The SAN region underlies au
Externí odkaz:
https://doaj.org/article/031c07dae2ec4107a35dfabd06f0e45d
Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells
Publikováno v:
Bio-Protocol, Vol 10, Iss 1 (2020)
Cardiac pacemaker cells of the sino-atrial node are responsible for the initiation of the heart beat and express an array of ion channels. The patch-clamp technique is the gold standard method for investigating the function of ion channels expressed
Externí odkaz:
https://doaj.org/article/ca95b30fd9d948ff86c777549a6a7bd5
Autor:
Duncan C. Miller, Stephen C. Harmer, Ariel Poliandri, Muriel Nobles, Elizabeth C. Edwards, James S. Ware, Tyson V. Sharp, Tristan R. McKay, Leo Dunkel, Pier D. Lambiase, Andrew Tinker
Publikováno v:
Stem Cell Research, Vol 25, Iss C, Pp 233-244 (2017)
The class Ia anti-arrhythmic drug ajmaline is used clinically to unmask latent type I ECG in Brugada syndrome (BrS) patients, although its mode of action is poorly characterised. Our aims were to identify ajmaline's mode of action in human induced pl
Externí odkaz:
https://doaj.org/article/ca9d87c0e4fa49e08673fd8726d3486f
Autor:
Dorota Zawada, Jessica Kornherr, Anna B. Meier, Gianluca Santamaria, Tatjana Dorn, Daniel Ortmann, Mark Lachmann, Mariaestela Ortiz, Stephen C. Harmer, Muriel Nobles, Andrew Tinker, Roger A. Pedersen, Phillip Grote, Karl-Ludwig Laugwitz, Alessandra Moretti, Alexander Goedel
Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor populations. Understanding the specification and differentiation of these distinct progenitor pools during human embryonic development is crucial for advancing our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c2f0a2fa5a40ebf0465ad0040a1bd6
https://doi.org/10.1101/2022.05.30.494027
https://doi.org/10.1101/2022.05.30.494027
Autor:
Cristina Morera, Jihee Kim, Amaia Paredes-Redondo, Muriel Nobles, Denis Rybin, Robert Moccia, Anna Kowala, Jinhong Meng, Seth Garren, Pentao Liu, Jennifer E Morgan, Francesco Muntoni, Nicolas Christoforou, Jane Owens, Andrew Tinker, Yung-Yao Lin
Mutations in thedystrophingene cause the most common and currently incurable Duchenne muscular dystrophy (DMD) characterized by progressive muscle wasting. Although abnormal Ca2+handling is a pathological feature of DMD, mechanisms underlying defecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44521229c905ddc8e2d9985a0443638a
https://doi.org/10.1101/2022.02.17.480850
https://doi.org/10.1101/2022.02.17.480850
Autor:
Andreas Ludwig, Muriel Nobles, Sonia Sebastian, Patricia B. Munroe, Andrew Tinker, Elena Tsisanova
Publikováno v:
Physiological genomics. 53(4)
We have assessed the role of ric-b8 in the control of heart rate after the gene was implicated in a recent genome-wide association study of resting heart rate. We developed a novel murine model in which it was possible to conditionally delete ric-8b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fb98b9d619ddd72d1c6b6e8c2a5f69
https://pubmed.ncbi.nlm.nih.gov/33719582
https://pubmed.ncbi.nlm.nih.gov/33719582
Publikováno v:
Bio Protoc
The cardiac conduction system allows the synchronized propagation of electrical activity through heart muscle. This is initiated by the spontaneous activity of the specialized pacemaker cells of the sino-atrial node (SAN). The SAN region underlies au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f046fe14834ac02593f177aebfdb1c8
https://europepmc.org/articles/PMC7842321/
https://europepmc.org/articles/PMC7842321/
Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells
Publikováno v:
Bio Protoc
Cardiac pacemaker cells of the sino-atrial node are responsible for the initiation of the heart beat and express an array of ion channels. The patch-clamp technique is the gold standard method for investigating the function of ion channels expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7865024c7fd4f9d93f6bd31a297b3ef5
https://pubmed.ncbi.nlm.nih.gov/33654711
https://pubmed.ncbi.nlm.nih.gov/33654711
Autor:
Kristie Wood, Kulvinder Lall, Alison M. Thomas, Malcolm Finlay, Muriel Nobles, Andrew Tinker, Charles A. Mein, Michael R. Barnes, Richard J. Schilling, Patricia B. Munroe, Claudia P. Cabrera
Publikováno v:
Physiol Genomics
Atrial fibrillation is a significant worldwide contributor to cardiovascular morbidity and mortality. Few studies have investigated the differences in gene expression between the left and right atrial appendages, leaving their characterization largel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0681b300e0367b511014a854a450425e
https://pubmed.ncbi.nlm.nih.gov/31172864
https://pubmed.ncbi.nlm.nih.gov/31172864