Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Muriel Eaton"'
Autor:
Zhixiong Ma, Muriel Eaton, Yushuang Liu, Jingliang Zhang, Xiaoling Chen, Xinyu Tu, Yiqiang Shi, Zhefu Que, Kyle Wettschurack, Zaiyang Zhang, Riyi Shi, Yueyi Chen, Adam Kimbrough, Nadia A. Lanman, Leah Schust, Zhuo Huang, Yang Yang
Publikováno v:
Neurobiology of Disease, Vol 168, Iss , Pp 105690- (2022)
Autism spectrum disorder (ASD) affects ~2% of the population in the US, and monogenic forms of ASD often result in the most severe manifestation of the disorder. Recently, SCN2A has emerged as a leading gene associated with ASD, of which abnormal sle
Externí odkaz:
https://doaj.org/article/e9f2b8419d55460c905c9f4e52c48026
Autor:
Parul Verma, Muriel Eaton, Achim Kienle, Dietrich Flockerzi, Yang Yang, Doraiswami Ramkrishna
Publikováno v:
Frontiers in Computational Neuroscience, Vol 14 (2020)
Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent, painful side effect which arises due to a number of chemotherapy agents. CIPN can have a prolonged effect on quality of life. Chemotherapy treatment is often reduced or stopped altoget
Externí odkaz:
https://doaj.org/article/a3651428950f40d3b864dc6e9e226144
Autor:
Emily Roggenkamp, Rachael M. Giersch, Emily Wedeman, Muriel Eaton, Emily Turnquist, Madison N. Schrock, Linah Alkotami, Thitikan Jirakittisonthon, Samantha E. Schluter-Pascua, Gareth H. Bayne, Cory Wasko, Megan Halloran, Gregory C. Finnigan
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Saccharomyces cerevisiae continues to serve as a powerful model system for both basic biological research and industrial application. The development of genome-wide collections of individually manipulated strains (libraries) has allowed for high-thro
Externí odkaz:
https://doaj.org/article/80bfc0f2668f48a18948b10a75d3bb5f
Autor:
Xiaoling Chen, Jean-Christophe Rochet, Chongli Yuan, Layan Yunis, J Marshall Shafer, Maria I. Olivero-Acosta, Muriel Eaton, Zhefu Que, Junkai Xie, Anke M Tukker, Jingliang Zhang, Tiange Xiao, Zhuo Huang, Chang-Deng Hu, Kyle Wettschurack, Jiaxiang Wu, Yang Yang, William C. Skarnes, Aaron B. Bowman, James A. Schaber, Darci J. Trader
Publikováno v:
J Neurosci
With the wide adoption of genomic sequencing in children having seizures, an increasing number ofSCN2Agenetic variants have been revealed as genetic causes of epilepsy. Voltage-gated sodium channel Nav1.2, encoded by geneSCN2A, is predominantly expre
Dissertation/ Thesis
Autor:
Muriel Eaton (12476532)
Recent advancements in genetics have revealed that SCN2A is one of the leading genes associated with neurodevelopmental disorders including autism spectrum disorder and epilepsy. In particular, loss-of-function and truncation variants account for a m
Autor:
Michael R. Ladisch, Yang Yang, Kaethe Beck, Muriel Eaton, Jeff S. McDermott, Zhefu Que, Riyi Shi, Jingliang Zhang
Publikováno v:
Pharmaceutical research. 38(7)
Pharmaceutical buffer systems, especially for injectable biologics such as monoclonal antibodies, are an important component of successful FDA-approved medications. Clinical studies indicate that buffer components may be contributing factors for incr
Autor:
Krishna Jayant, J. Hea Lee, Tiange Xiao, James A. Schaber, Shirong Lai, Maria I. Olivero-Acosta, Zhixiong Ma, Yang Yang, Muriel Eaton, Jiayingzi Wu, Zhefu Que, Yueyang Wang, Nadia A. Lanman, T. S. Ahmad, William C. Skarnes, Xiaoling Chen, Jing Zhang, Anthony C Park, Ying Li, Zhuo Huang
Scn2a encodes voltage-gated sodium channel NaV1.2, which mediates neuronal firing. The current paradigm suggests that NaV1.2 gain-of-function variants enhance neuronal excitability resulting in epilepsy, whereas NaV1.2 deficiency impairs neuronal exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efcd393d57f7585aa2fbba8bc79267d3
https://doi.org/10.1101/2021.02.02.429384
https://doi.org/10.1101/2021.02.02.429384
Autor:
William C. Skarnes, Jiaxiang Wu, Shirong Lai, Muriel Eaton, Huynhvi P Nguyen, Jingliang Zhang, Xiaoling Chen, Zhefu Que, Emma E Lietzke, Sophia Palant, Yang Yang, Tiange Xiao, Zhixiong Ma, Chloe Maricela Romero, Anthony C Park, Ji Hea Lee, Emily Rose Coleman, Yushuang Liu, Zhuo Huang, Wendy Ann Koss
Publikováno v:
Genes, Brain and Behavior. 20
Large-scale genetic studies revealed SCN2A as one of the most frequently mutated genes in patients with neurodevelopmental disorders. SCN2A encodes for the voltage-gated sodium channel isoform 1.2 (Nav 1.2) expressed in the neurons of the central ner
Autor:
Muriel, Eaton, Jingliang, Zhang, Zhixiong, Ma, Anthony C, Park, Emma, Lietzke, Chloé M, Romero, Yushuang, Liu, Emily R, Coleman, Xiaoling, Chen, Tiange, Xiao, Zhefu, Que, Shirong, Lai, Jiaxiang, Wu, Ji Hea, Lee, Sophia, Palant, Huynhvi P, Nguyen, Zhuo, Huang, William C, Skarnes, Wendy A, Koss, Yang, Yang
Publikováno v:
Genes, brain, and behaviorREFERENCES. 20(4)
Large-scale genetic studies revealed SCN2A as one of the most frequently mutated genes in patients with neurodevelopmental disorders. SCN2A encodes for the voltage-gated sodium channel isoform 1.2 (Na
Autor:
Emily Rose Coleman, Tiange Xiao, Chloe Maricela Romero, William C. Skarnes, Zhixiong Ma, Emma E Lietzke, Xiaoling Chen, Muriel Eaton, Anthony C Park, Yushuang Liu, Zhuo Huang, Wendy Ann Koss, Jingliang Zhang, Yang Yang
Recent large-scale genomic studies have revealedSCN2Aas one of the most frequently mutated gene in patients with neurodevelopmental disorders including autism spectrum disorder and intellectual disability.SCN2Aencodes for voltage-gated sodium channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9af8c632f3c58504bb2bd0b929a74346
https://doi.org/10.1101/2020.06.23.150367
https://doi.org/10.1101/2020.06.23.150367