Výsledky vyhledávání - "Muriel Duflos"

Akademický článek

The Marine-Derived Fungus Clonostachys rosea, Source of a Rare Conjugated 4-Me-6E,8E-hexadecadienoic Acid Reducing Viability of MCF-7 Breast Cancer Cells and Gene Expression of Lipogenic Enzymes

Autor: Ana Camila Dos Santos Dias, Nicolas Ruiz, Aurélie Couzinet-Mossion, Samuel Bertrand, Muriel Duflos, Yves-François Pouchus, Gilles Barnathan, Hassan Nazih, Gaetane Wielgosz-Collin

Publikováno v: Marine Drugs, Vol 13, Iss 8, Pp 4934-4948 (2015)

A marine-derived strain of Clonostachys rosea isolated from sediments of the river Loire estuary (France) was investigated for its high lipid production. The fungal strain was grown on six different culture media to explore lipid production changes.

Externí odkaz: https://doaj.org/article/cbf53c08a8704edfb935443c9a3affce

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Novel approach towards 3,7-disubstituted 1,6-naphthyridin-4(1H)-ones exploiting cross-coupling and SNAr reactions of a dihalogenated compound

Autor: Dylan Sérillon, Thomas Yvorra, Alain Tonnerre, David Montoir, Ousmane Dembélé, Muriel Duflos, Jean-Michel Robert, Marc-Antoine Bazin

Publikováno v: Tetrahedron Letters. 59:3519-3523

A new route towards the synthesis of a series of 3,7-disubstituted 1,6-naphthyridin-4(1H)-ones in moderate to good yields is reported. The strategy involves the preparation of a 3,7-dihalogenated compound that undergoes differential functionalization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c095c1fee6973365e44c85e29c5d4d4a
https://doi.org/10.1016/j.tetlet.2018.08.013

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Novel 1,6-naphthyridin-2(1H)-ones as potential anticancer agents targeting Hsp90

Autor: Alain Tonnerre, Marc-Antoine Bazin, Sophie Barillé-Nion, Muriel Duflos, Philippe Juin, David Montoir

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2016, 119, pp.17-33. ⟨10.1016/j.ejmech.2016.04.050⟩
European Journal of Medicinal Chemistry, Elsevier, 2016, 119, pp.17-33. ⟨10.1016/j.ejmech.2016.04.050⟩

International audience; Hsp90 is an ATP-dependent chaperone known to be overexpressed in many cancers. This way, Hsp90 is an important target for drug discovery. Novobiocin, an aminocoumarin antibiotic, was reported to inhibit Hsp90 targeting C-termi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a281a0a905ddeb26b1b375b11c0e47
https://doi.org/10.1016/j.ejmech.2016.04.050

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The Marine-Derived Fungus Clonostachys rosea, Source of a Rare Conjugated 4-Me-6E,8E-hexadecadienoic Acid Reducing Viability of MCF-7 Breast Cancer Cells and Gene Expression of Lipogenic Enzymes

Autor: Samuel Bertrand, Gaëtane Wielgosz-Collin, Gilles Barnathan, Hassan Nazih, Nicolas Ruiz, Ana Camila Dos Santos Dias, Y.F. Pouchus, Aurélie Couzinet-Mossion, Muriel Duflos

Publikováno v: Marine Drugs, Vol 13, Iss 8, Pp 4934-4948 (2015)
Marine Drugs
Volume 13
Issue 8
Pages 4934-4948

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40eafdbb1bdf6e49f0dc374c942b3e8b
http://www.mdpi.com/1660-3397/13/8/4934

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Efficient one-pot synthesis of 3,7-disubstituted 1,6-naphthyridin-2(1H)-ones through regioselective palladium-catalyzed cross-coupling and SNAr reactions

Autor: Alain Tonnerre, Marc-Antoine Bazin, Muriel Duflos, David Montoir

Publikováno v: Tetrahedron. 71:3303-3313

An efficient synthesis of original 3,7-disubstituted 1,6-naphthyridones via one-pot palladium-catalyzed cross-coupling and SNAr reactions is reported. Buchwald–Hartwig amination was investigated to introduce a large variety of nitrogen-containing n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54f9c3f64bcc5995ae27e3bab60f6958
https://doi.org/10.1016/j.tet.2015.03.110

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Differential Functionalization of 1,6-Naphthyridin-2(1H)-ones through Sequential One-Pot Suzuki-Miyaura Cross-Couplings

Autor: Alain Tonnerre, Muriel Duflos, Marc-Antoine Bazin, David Montoir

Publikováno v: European Journal of Organic Chemistry. 2014:1487-1495

A practical synthesis of 7-chloro-3-iodo-1-methyl-1,6-naphthyridin-2(1H)-one is described that starts from 2-chloro-4-(methylamino)nicotinaldehyde. The dihalo compound then undergoes sequential, site-selective Suzuki–Miyaura cross-coupling reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a13b0afeb3e6a678aa29aa32f9c774e
https://doi.org/10.1002/ejoc.201301631

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First synthesis of 4-aminopyrido[2′,3′:4,5]furo[3,2-d]pyrimidines

Autor: Carole Dubouilh-Benard, Thierry Besson, Marie-Renée Nourrisson, Yvonnick Loidreau, Muriel Duflos, Pascal Marchand

Publikováno v: Tetrahedron Letters
Tetrahedron Letters, Elsevier, 2012, 53 (8), pp.944-947. ⟨10.1016/j.tetlet.2011.12.042⟩

This Letter describes for the first time the synthesis of pyrido[2′,3′:4,5]furo[3,2-d]pyrimidines substituted by a primary or secondary amino group on position 4 of the pyrimidine ring. Application of microwave irradiation technology allowed fast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3acf45ecdac322caa61c9b4c32f3a05
https://doi.org/10.1016/j.tetlet.2011.12.042

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Design, Synthesis, and in vitro Antifungal Activity of 1-[(4-Substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

Autor: Muriel Duflos, Marc Le Borgne, Rémi Guillon, Francis Giraud, Carine Picot, Florent Morio, Fabrice Pagniez, Damien Crepin, Patrice Le Pape, Cédric Logé

Publikováno v: ChemMedChem. 6:816-825

As part of our studies focused on the design of 1-[((hetero)aryl- and piperidinylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents, we report the development of new extended benzylamine derivatives substituted at the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d4946e0b389553d58c48d71b3bf9f5
https://doi.org/10.1002/cmdc.201000530

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