Site-Specific Conjugation for Fully Controlled Glycoconjugate Vaccine Preparation

Autor: Aline Pillot, Alain Defontaine, Amina Fateh, Annie Lambert, Maruthi Prasanna, Mathieu Fanuel, Muriel Pipelier, Noemi Csaba, Typhaine Violo, Emilie Camberlein, Cyrille Grandjean

Publikováno v: Frontiers in Chemistry, Vol 7 (2019)

Glycoconjugate vaccines are formed by covalently link a carbohydrate antigen to a carrier protein whose role is to achieve a long lasting immune response directed against the carbohydrate antigen. The nature of the sugar antigen, its length, its rati

Externí odkaz: https://doaj.org/article/f04f8db38ce444cb962c698baea28091

Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents

Autor: Eric Léonel, Morgane Rousselle, Didier Dubreuil, Gervaise Loirand, Florian Dilasser, Rémy Le Guével, Erwan Le Gall, Muriel Pipelier, Vincent Sauzeau, Stéphane Sengmany, Jacques Lebreton, Mathilde Sitter, Thierry Martens

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (5), pp.755-760. ⟨10.1016/j.bmcl.2018.12.050⟩
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (5), pp.755-760. ⟨10.1016/j.bmcl.2018.12.050⟩
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2019, 29 (5), pp.755-760. ⟨10.1016/j.bmcl.2018.12.050⟩

International audience; Various 3-amino-, 3-aryloxy- and alkoxy-6-arylpyridazines have been synthesized by an electrochemical reductive cross-coupling between 3-amino-, 3-aryloxy- or 3-alkoxy-6-chloropyridazines and aryl or heteroaryl halides. In vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35eb0e243984331307a465e5b00ad21
https://doi.org/10.1016/j.bmcl.2018.12.050

Synthesis of Constrained C-Glycosyl Amino Acid Derivatives Involving 1,3-Dipolar Cycloaddition of Cyclic Nitrone as Key Step

Autor: Arnaud Martel, Florian Rouzier, Stéphane Guillarme, Gilles Dujardin, Rosanne Sillé, Arnaud Tessier, Arnaud Nourry, Muriel Pipelier, Ophélie Montiège

Publikováno v: European Journal of Organic Chemistry
European Journal of Organic Chemistry, Wiley-VCH Verlag, 2020, ⟨10.1002/ejoc.202001162⟩

International audience; An efficient two-step strategy for the synthesis of constrained C-glycosyl amino acid derivatives from C-vinylglycosides involving a 1,3-dipolar cycloaddition using L-(-)menthone-derived nitrone as the key step is described. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a9ea68c9d9c3dce5639fed2eda9069
https://hal.archives-ouvertes.fr/hal-03085851

Characterization of New Oligosaccharides Obtained by An Enzymatic Cleavage of the Exopolysaccharide Produced by the Deep-Sea Bacterium Alteromonas infernus Using its Cell Extract

Autor: Hélène Rogniaux, Katy Akoumany, David Ropartz, Sylvia Colliec-Jouault, Christine Delbarre-Ladrat, Laëtitia Marchand, Mathieu Fanuel, Muriel Pipelier, Corinne Sinquin, Agata Zykwinska

Publikováno v: Molecules (1420-3049) (MDPI AG), 2019-10, Vol. 24, N. 19, P. 3441 (15p.)
Molecules
Molecules, MDPI, 2019, 24 (19), pp.1-15. ⟨10.3390/molecules24193441⟩
Molecules, Vol 24, Iss 19, p 3441 (2019)
Volume 24
Issue 19

Bacteria from deep-sea hydrothermal vents constitute an attractive source of bioactive molecules. In particular, exopolysaccharides (EPS) produced by these bacteria become a renewable source of both biocompatible and biodegradable molecules. The low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851244f29a5fe92ca149d25e4d9f392d
https://archimer.ifremer.fr/doc/00515/62644/

3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation

Autor: Arnaud Tessier, Jézabel Rocher, Katy Akoumany, Allan Patinec, Virginie Blot, Didier Dubreuil, Jacques Le Pendu, Jean-Yves Le Questel, Bruno Linclau, Samuel Golten, Jérôme Graton, Muriel Pipelier, Denis Jacquemin, J.Y. Douillard, Jacques Lebreton

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 178, pp.195-213. ⟨10.1016/j.ejmech.2019.05.069⟩

20 iNKT cells recognize CD1d/-galactosylceramide (-GalCer) complexes via their invariant 21 TCR receptor and stimulate the immune response. Many -GalCer analogues have been 22 investigated to interrogate this interaction. Following our previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7b38d7d1fdee0ea28dfc8baaaa2f4f
https://pubmed.ncbi.nlm.nih.gov/31185411