Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Murid herpesvirus 4"'
Publikováno v:
Viruses, Vol 11, Iss 8, p 757 (2019)
Murid herpesvirus-4 (MuHV-4), a natural gammaherpesvirus of rodents, can infect the mouse through the nasal mucosa, where it targets sustentacular cells and olfactory neurons in the olfactory epithelium before it propagates to myeloid cells and then
Externí odkaz:
https://doaj.org/article/545051ddf4e643f6ad1ab9fc6e86ce33
Autor:
Martin Delguste, Florian Cotin, David Alsteens, Laurent Gillet, Grégoire Le Brun, Bénédicte Machiels
Publikováno v:
Nano Letters, Vol. 21, no. 1, p. 847-853 (2021)
Viruses are one of the most efficient pathogenic entities on earth, resulting from millions of years of evolution. Each virus particle carries the minimum number of genes and proteins to ensure their reproduction within host cells, hijacking some hos
Publikováno v:
Immunology & Cell Biology. 98:332-343
Vaccination against γ-herpesviruses has proved difficult. CD4+ T cells are essential to contain infection, but how best to prime them and whether this can reduce viral loads remain unclear. To address these questions, we used ovalbumin (OVA) as a mo
Autor:
K Briestenská, J Mistríková
Publikováno v:
Acta virologica. 64:167-176
The aim of this work was to give an overview of murid herpesvirus 4 (MuHV-4) (synonyms: murine gammaherpesvirus 68, mouse herpesvirus strain 68), the first model for the study of human and animal oncogenic gammaherpesviruses. Based on our results con
Publikováno v:
Immunology & Cell Biology. 98:67-78
γ-Herpesviruses establish latent infections of lymphocytes and drive their proliferation, causing cancers and motivating a search for vaccines. Effective vaccination against murid herpesvirus-4 (MuHV-4)-driven lymphoproliferation by latency-impaired
Autor:
Clara Lawler, Philip G. Stevenson
Publikováno v:
Journal of Virology. 94
CD4+ T cells are essential to control herpesviruses. Murid herpesvirus 4 (MuHV-4)-driven lung disease in CD4+ T-cell-deficient mice provides a well-studied example. Protective CD4+ T cells have been hypothesized to kill infected cells directly. Howev
Publikováno v:
Journal of Antimicrobial Chemotherapy. 73:2095-2103
Objectives To investigate the efficacy of cidofovir to block gammaherpesvirus replication in the context of sexual transmission. Methods A luciferase-expressing strain of murid herpesvirus 4 (MuHV-4) was used to monitor genital virus excretion from i
Autor:
J. Pedro Simas, Marta Pires de Miranda, Colin E. McVey, Kenneth M. Kaye, Ana Patrícia Quendera
Publikováno v:
Journal of Virology
KSHV is a human oncogenic virus for which there is no tractable, immunocompetent animal model of infection. MuHV-4, a related rodent gammaherpesvirus, enables pathogenesis studies in mice. In latency, both viruses persist as extrachromosomal, circula
Autor:
Justine Javaux, Daniel Desmecht, Benjamin G Dewals, Mickael Dourcy, Philippe Martinive, Hamida Hammad, Bénédicte Machiels, Claire Mesnil, Alain Vanderplasschen, Laurent Gillet, Bart N. Lambrecht, François Lallemand, Martin Guilliams, Fabrice Bureau, Xue Xiao, Catherine Sabatel
Publikováno v:
Nature Immunology, 18(12), 1310-1320. Nature Publishing Group
The hygiene hypothesis postulates that the recent increase in allergic diseases such as asthma and hay fever observed in Western countries is linked to reduced exposure to childhood infections. Here we investigated how infection with a gammaherpesvir
Publikováno v:
Journal of Virology. 90:2756-2766
Cytomegaloviruses (CMVs) infect the lungs and cause pathological damage there in immunocompromised hosts. How lung infection starts is unknown. Inhaled murine CMV (MCMV) directly infected alveolar macrophages (AMs) and type 2 alveolar epithelial cell