The high affinity dopamine uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization

Autor: Velázquez-Sánchez, C., Ferragud, A., Murga, J., Cardá, M., Canales, J.J.

Publikováno v: In European Neuropsychopharmacology 2010 20(7):501-508

N-alpha-Aminoacyl Colchicines as Promising Anticancer Agents

Autor: Marzo-Mas A, Conesa-Milián L, Noppen S, Liekens S, Falomir E, Murga J, Carda M, Marco JA

Publikováno v: Medicinal chemistry
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
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In the last years, many efforts have been made to find colchicine derivatives with reduced toxicity. Additionally, the deregulation of amino acids uptake by cancer cells provides an opportunity to improve anticancer drug effectiveness.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3e1359b5f567fee2ee6fe090608991a0
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6970

Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressions

Autor: Sánchez-Peris M, Murga J, Falomir E, Carda M, Marco JA

Publikováno v: CHEMICAL BIOLOGY & DRUG DESIGN
r-FISABIO. Repositorio Institucional de Producción Científica
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CHEM BIOL DRUG DES
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds were then evaluated for their abil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::275b859e7288343cdaf2db30a87930cc
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4555

Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions

Autor: Sánchez-Peris M, Falomir E, Murga J, Carda M, Marco JA

Publikováno v: BIOORGAN MED CHEM
r-FISABIO. Repositorio Institucional de Producción Científica
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r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell line (HEK-293). 29 selected compounds have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::304c9d740a4f370af1337f2aa71d5e72
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4556

Inhibitory effect of pironetin analogue/colchicine hybrids on the expression of the VEGF, hTERT and c-Myc genes

Autor: Vilanova C, Díaz-Oltra S, Murga J, Falomir E, Carda M, Marco JA

Publikováno v: BIOORG MED CHEM LETT
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
r-FISABIO. Repositorio Institucional de Producción Científica
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A small group of hybrid molecules composed of a colchicine moiety and a pironetin analogue fragment have been investigated for their ability to inhibit the expression of the VEGF, hTERT and c-Myc genes. The VEGF gene is involved in the generation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4642238455c2a80c4bbb8d777549e87c
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4565