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Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose

Autor: Cheung, S.Y.A., Rodgers, T., Aarons, Leon, Gueorguieva, I., Dickinson, G.L., Murby, Susan, Brown, C, Collins, Brent, Rowland, Malcolm

Publikováno v: Cheung, S Y A, Rodgers, T, Aarons, L, Gueorguieva, I, Dickinson, G L, Murby, S, Brown, C, Collins, B & Rowland, M 2017, ' Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose ', British Journal of Pharmacology, pp. 1 . https://doi.org/10.1111/bph.14071

Background and PurposeWhole body physiologically based pharmacokinetic (PBPK) models have been increasingly applied in drug development to describe kinetic events of therapeutic agents in animals and humans. The advantage of such modelling is the abi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::9765c5610ba66ec3228b115c3a63a2e1
https://www.research.manchester.ac.uk/portal/en/publications/whole-body-physiologically-based-modelling-of-blockers-in-the-rat-events-in-tissues-and-plasma-following-an-iv-bolus-dose(10828764-7d0f-4073-ac93-840472d39bdf).html

Development of a Whole Body Physiologically Based Model to Characterise the Pharmacokinetics of Benzodiazepines. 1: Estimation of Rat Tissue-Plasma Partition Ratios

Autor: Gueorguieva, Ivelina, Nestorov, Ivan, Murby, Susan, Gisbert, Sophie, Collins, Brent, Dickens, Kelly, Duffy, Judith, Hussain, Ziad, Rowland, Malcolm

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics; August 2004, Vol. 31 Issue: 4 p269-298, 30p

Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides

Autor: He, Yan-Ling, Murby, Susan, Warhurst, Geoffrey, Gifford, Larry, Walker, David, Ayrton, John, Eastmond, Richard, Rowland, Malcolm

Publikováno v: Journal of Pharmaceutical Sciences; May 1998, Vol. 87 Issue: 5 p626-633, 8p