Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Murat Digicaylioglu"'
Autor:
Jacqueline Tan, Murat Digicaylioglu, Stacy X.J. Wang, Jonathan Dresselhuis, Shoukat Dedhar, Julia Mills
Publikováno v:
Heliyon, Vol 5, Iss 8, Pp e02294- (2019)
Insulin promotes neuronal survival by activating a phosphatidylinositol 3-kinase (PI 3-kinase)/AKT-dependent signaling pathway and reducing caspase activation. We investigated a role for integrin-linked kinase (ILK) in insulin-mediated cell survival
Externí odkaz:
https://doaj.org/article/08af1055d9534e7782679515ad680f53
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68281 (2013)
Ischemic stroke is the leading cause of serious, long-term adult disability and is associated with sensorimotor and cognitive impairments due to neuronal degeneration. Currently, recombinant tissue plasminogen activator (rTPA) is the only FDA-approve
Externí odkaz:
https://doaj.org/article/d93ec904e8a24f72aecb7fbf5700b416
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18711 (2011)
The blood brain barrier (BBB) is impermeable to most drugs, impeding the establishment of novel neuroprotective therapies and strategies for many neurological diseases. Intranasal administration offers an alternative path for efficient drug delivery
Externí odkaz:
https://doaj.org/article/0ab9b55f18124030bff16259348c7734
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14724 (2011)
MicroRNAs (miRNAs) are small, non-protein-coding RNA molecules that modulate gene translation. Their expression is altered in many central nervous system (CNS) injuries suggesting a role in the cellular response to stress. Current studies in brain ti
Externí odkaz:
https://doaj.org/article/a890774a89684d1b9effe364b1e0fcf8
Publikováno v:
Neural Regeneration Research
The mechanistic target of rapamycin (mTOR) is an intracellular protein kinase that functions as an energy and nutrient sensor in the cellular microenvironment of neurons. Modulation of mTOR is vital when nutrient and energy sources become limited. Hy
Autor:
Naomi L. Sayre, Katherine G. Mayfield, Nancy K Glober, Sadiya Ahmad, Shane Sprague, Lauren Fletcher, Murat Digicaylioglu
Publikováno v:
Neuroscience Journal, Vol 2019 (2019)
Neuroscience Journal
Neuroscience Journal
After traumatic brain injury (TBI), multiple ongoing processes contribute to worsening and spreading of the primary injury to create a secondary injury. One major process involves disrupted fluid regulation to create vascular and cytotoxic edema in t
Autor:
Stacy X.J. Wang, Julia Mills, Shoukat Dedhar, Jonathan Dresselhuis, Murat Digicaylioglu, Jacqueline Tan
Publikováno v:
Heliyon
Heliyon, Vol 5, Iss 8, Pp e02294-(2019)
Heliyon, Vol 5, Iss 8, Pp e02294-(2019)
Insulin promotes neuronal survival by activating a phosphatidylinositol 3-kinase (PI 3-kinase)/AKT-dependent signaling pathway and reducing caspase activation. We investigated a role for integrin-linked kinase (ILK) in insulin-mediated cell survival
Autor:
Shane Sprague, R. Justin Garling, James D. Lechleiter, Lora Talley Watts, Murat Digicaylioglu, Wei Zheng, David Jiménez
Publikováno v:
Journal of Neurotrauma. 30:55-66
Traumatic brain injury (TBI) is the leading cause of death and disability in children and young adults. Neuroprotective agents that may promote repair or counteract damage after injury do not currently exist. We recently reported that stimulation of
Publikováno v:
Expert Opinion on Drug Delivery. 8:19-32
Erythropoietin (EPO) is a growth hormone and cytokine that plays an important role in erythropoiesis and neuroprotection. However, EPO treatment for neurological diseases requires repeated injections or high-dose systemic administration, which may ca
Autor:
Evan Y. Snyder, Stephen Ashwal, Murat Digicaylioglu, Hou Rou Tian, Nejmi Dilmac, Richard E. Hartman, Beatriz Tone, Andre Obenaus
Publikováno v:
Annals of Neurology. 69:282-291
Objective: Quantitative magnetic resonance imaging (MRI) can serially and noninvasively assess the degree of injury in rat pup models of hypoxic ischemic injury (HII). It can also noninvasively monitor stem cell migration following iron oxide prelabe