Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Murali Rajagopalan"'
Publikováno v:
Journal of Anaesthesiology Clinical Pharmacology, Vol 35, Iss 2, Pp 220-226 (2019)
Background and Aims: Safe medication is an important part of anesthesia practice. Even though anesthesia practice has become safer with various patient safety initiatives, it is not completely secure from errors which can sometimes lead to devastatin
Externí odkaz:
https://doaj.org/article/eced880411614f9a9d494813dba41a06
Autor:
Gajendiran, Mani, Gopi, Venkatachalam, Elangovan, Vellaichamy, Murali, Rajagopalan Venkatakrishna, Balasubramanian, Sengottuvelan
Publikováno v:
In Colloids and Surfaces B: Biointerfaces 1 April 2013 104:107-115
Autor:
Melissa Kirkland, Randal M. Bugianesi, Melodie Christensen, Maria E. Trujillo, Michele Pachanski, Richard Tschirret-Guth, Josien Hubert B, Adam B. Weinglass, Sarah Souza, Ravi P. Nargund, Christopher W. Plummer, Andrew D. Howard, Joel Mane, Louis-Charles Campeau, Robert K. Orr, Daniel Kosinski, Xiaoping Zhang, Boonlert Cheewatrakoolpong, Jerry Di Salvo, Michael W. Miller, William K. Hagmann, Helen Chen, Steven L. Colletti, Andrew Nolting, Michael Wright, Matthew J. Clements, Murali Rajagopalan
Publikováno v:
ACS Medicinal Chemistry Letters. 8:221-226
GPR40 is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial agonists elicits insulin secr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6942c1dd589ae2364bd7ea069018de04
https://doi.org/10.1021/acsmedchemlett.6b00443
https://doi.org/10.1021/acsmedchemlett.6b00443
Publikováno v:
Journal of Anaesthesiology, Clinical Pharmacology
Journal of Anaesthesiology Clinical Pharmacology, Vol 35, Iss 2, Pp 220-226 (2019)
Journal of Anaesthesiology Clinical Pharmacology, Vol 35, Iss 2, Pp 220-226 (2019)
Background and Aims: Safe medication is an important part of anesthesia practice. Even though anesthesia practice has become safer with various patient safety initiatives, it is not completely secure from errors which can sometimes lead to devastatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf6f6e7533514e38f97f26d25fed188
https://pubmed.ncbi.nlm.nih.gov/31303712
https://pubmed.ncbi.nlm.nih.gov/31303712
Autor:
Ruo Xu, Monica Vicarel, Lili Zhang, Duane A. Burnett, Giuseppe Terracina, Lynn A. Hyde, Wen-Lian Wu, Qi Zhang, Thomas Bara, William J. Greenlee, Robert A. Del Vecchio, Amin A. Nomeir, Mcbriar Mark D, Mary Cohen-Williams, Josien Hubert B, Murali Rajagopalan, Julie Lee, Theodros Asberom, Martin S. Domalski, John W. Clader, Chad Bennett, Lixin Song, Eric M. Parker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:844-849
An investigation is detailed of the structure activity relationships (SAR) of two sulfone side chains of compound (−)- 1a (SCH 900229), a potent, PS1-selective γ-secretase inhibitor and clinical candidate for the treatment of Alzheimer’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7acb8f10ab43bcf5cd40b91f4b39ca
https://doi.org/10.1016/j.bmcl.2012.11.047
https://doi.org/10.1016/j.bmcl.2012.11.047
Autor:
Xianhai Huang, William J. Greenlee, Hongmei Li, Murali Rajagopalan, Robert G. Aslanian, Josien Hubert B, Dmitri A. Pissarnitski, Xiaohong Zhu, Monica Vicarel, Alexei V. Buevich, Anandan Palani, Theodros Asberom, Zhiqiang Zhao, Zhaoning Zhu
Publikováno v:
Tetrahedron Letters. 53:6451-6455
An efficient synthesis of fused morpholine oxadiazoline core structures was accomplished in an effort to identify optimum gamma secretase modulator leads in the treatment of Alzheimer’s disease. Reaction pathways were proposed for the key intramole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a954853234ac2b06079affa77807b775
https://doi.org/10.1016/j.tetlet.2012.09.070
https://doi.org/10.1016/j.tetlet.2012.09.070
Autor:
Leonard Favreau, Eric M. Parker, Thomas A. Bara, Amin A. Nomeir, Lynn A. Hyde, Lili Zhang, Murali Rajagopalan, Lixin Song, William J. Greenlee, Qi Zhang, John W. Clader, Hubert B. Josien
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6032-6037
A new class of 2,6-disubstituted morpholine N-arylsulfonamide gamma-secretase inhibitors was designed based on the introduction of a morpholine core in lieu or piperidine in our lead series. This resulted in compounds with improved CYP 3A4 profiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e31c6b945a8b2d784744d5c1770efe
https://doi.org/10.1016/j.bmcl.2009.09.055
https://doi.org/10.1016/j.bmcl.2009.09.055
Autor:
Lili Zhang, John W. Clader, Thomas A. Bara, Lixin Song, Amin A. Nomeir, Mark D. McBriar, Hongmei Li, Ruo Xu, William J. Greenlee, Theodros Asberom, Dmitri A. Pissarnitski, Murali Rajagopalan, Zhiqiang Zhao, Hubert B. Josien
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6290-6294
Development of cis-2,4,6-trisubstituted piperidine N-arylsulfonamides as γ-secretase inhibitors for the potential treatment of Alzheimer’s disease (AD) is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55dfdfb8104c952717f1e5d1cfe72bef
https://doi.org/10.1016/j.bmcl.2007.09.006
https://doi.org/10.1016/j.bmcl.2007.09.006
Autor:
Richard A. Hudson, L. M. Viranga Tillekeratne, Mamoun M. Alhamadsheh, Shuchi Gupta, Murali Rajagopalan
Publikováno v:
Synthesis. 2007:3512-3518
Efficient asymmetric syntheses of both naturally occurring and non-naturally occurring enantiomers of gonioheptolide A are reported. The absolute configuration of (+)-gonioheptolide A was established by NOESY, Mosher ester analysis, and comparison wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b755f64e2061d00a747bbe80981a8ae4
https://doi.org/10.1055/s-2007-990862
https://doi.org/10.1055/s-2007-990862
Autor:
Leonard Favreau, Dmitri A. Pissarnitski, Eric M. Parker, Zhiqiang Zhao, Lili Zhang, Hubert B. Josien, Lynn A. Hyde, Gwendolyn T. Wong, Theodros Asberom, John W. Clader, Thomas A. Bara, Murali Rajagopalan, Amin A. Nomeir, William J. Greenlee, Qi Zhang, Lixin Song
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5330-5335
The design and development of a new class of small 2,6-disubstituted piperidine N-arylsulfonamide gamma-secretase inhibitors is reported. Lowering molecular weight including the use of conformational constraint led to compounds with less CYP 3A4 liab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5957002f712a344f6f56d867f752f6cb
https://doi.org/10.1016/j.bmcl.2007.08.013
https://doi.org/10.1016/j.bmcl.2007.08.013