Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Murali K. Yanda"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1517-1529 (2021)
Background & Aims: Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in PKHD1, encoding fibrocystin/polyductin (FPC). Severe disease occurs in perinates. Those who survive the neonatal period face a myriad of comorbidities,
Externí odkaz:
https://doaj.org/article/e684dd6174c740629decf06a8b20f547
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G404-G414
ARPKD is a multiorgan genetic disorder resulting in newborn morbidity and mortality. There is a critical need for new therapies to treat this disease. We show that persistent cholangiocytes proliferation occurs in a mouse model of ARPKD along with mi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1517-1529 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1517-1529 (2021)
Background & Aims Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in PKHD1, encoding fibrocystin/polyductin (FPC). Severe disease occurs in perinates. Those who survive the neonatal period face a myriad of comorbidities,
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 318:G120-G129
Clostridium difficile (CD) is a common pathogen that causes severe gastrointestinal inflammatory diarrhea in patients undergoing antibiotic therapy. Its virulence derives from two toxins, toxin CD, A and B (TcdA and TcdB) (Borriello et al. Rev Infect
Publikováno v:
J Biol Chem
Autosomal-dominant polycystic kidney disease (ADPKD) induces a secretory phenotype, resulting in multiple fluid-filled cysts. We have previously demonstrated that VX-809, a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR),
Publikováno v:
Cell Calcium
Mutations in either of the polycystic kidney disease genes, PKD1 or PKD2, engender the growth of cysts, altering renal function. Cystic growth is supported by major changes in cellular metabolism, some of which involve the mitochondrion, a major stor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060905f80c36677231e998717fa5494a
https://europepmc.org/articles/PMC8840832/
https://europepmc.org/articles/PMC8840832/
Autor:
Liudmila Cebotaru, Murali K. Yanda
Publikováno v:
FASEB J
Autosomal dominant polycystic kidney disease (ADPKD) is associated with the formation of renal cysts. We have devised a therapeutic approach, based on reversing the cyst phenotype from secretion to absorption by using VX-809, a modulator of the cysti
Transduction of Surface and Basal Cells in Rhesus Macaque Lung Following Repeat Dosing with AAV1CFTR
Publikováno v:
Hum Gene Ther
To test the effectiveness of repeat dosing, we sprayed two doses (10(13) vg each) of AAV1Δ27-264-CFTR into airways of four rhesus monkeys at 0 and 30 days, followed by a single dose of 10(13) vg of AAV1GFP on day 60. Monkeys were sacrificed on day 9
Autor:
Inna Sabirzhanova, William B. Guggino, Qiangni Liu, Liudmila Cebotaru, Emily Bergbower, Clément Boinot, Murali K. Yanda
Publikováno v:
Journal of Cystic Fibrosis. 17:582-594
The missing phenylalanine at position 508, located in nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane regulator (CFTR), is the most common cystic fibrosis mutation. Severe disease-causing mutations also occur in NBD2. To provide
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Clostridium difficile (CD) is a common pathogen that causes severe gastrointestinal inflammatory diarrhea in patients undergoing antibiotic therapy. Its virulence derives from two toxins, toxin CD, A and B (TcdA and TcdB) (Borriello et al. Rev Infect