Výsledky vyhledávání - "Murali K Mallela"

Akademický článek

Propylthiouracil is teratogenic in murine embryos.

Autor: Valeria C Benavides, Murali K Mallela, Carmen J Booth, Christopher C Wendler, Scott A Rivkees

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35213 (2012)

Hyperthyroidism during pregnancy is treated with the antithyroid drugs (ATD) propylthiouracil (PTU) and methimazole (MMI). PTU currently is recommended as the drug of choice during early pregnancy. Yet, despite widespread ATD use in pregnancy, formal

Externí odkaz: https://doaj.org/article/8e398444428343ba9e5e081515650d78

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Evaluation of Developmental Toxicity of Propylthiouracil and Methimazole

Autor: Ryan R. Poulsen, Marie Strobl, Scott A. Rivkees, Carmen J. Booth, Christopher C. Wendler, Murali K. Mallela

Publikováno v: Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:300-307

BACKGROUND Propylthiouracil (PTU) and methimazole (MMI) are antithyroid drugs used to treat hyperthyroidism. Despite the widespread use of PTU and MMI during pregnancy, modest clinical data and less animal data are available on the teratogenic potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72c6ca7bb8c0f3e3d28636a4e33f11b7
https://doi.org/10.1002/bdrb.21113

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Neural tube defects in mice exposed to tap water

Autor: Stephen R. Werre, Murali K Mallela, Terry C. Hrubec

Publikováno v: Environmental Toxicology. 26:633-640

In May of 2006 we suddenly began to observe neural tube defects (NTDs) in embryos of untreated control mice. We hypothesized the mice were being exposed unknowingly to a teratogenic agent and investigated the cause. Our results suggested that NTDs we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4d5f7468b58260366fa9e3d1ec964a
https://doi.org/10.1002/tox.20600

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Late-gestation ventricular myocardial reduction in fetuses of hyperglycemic CD1 mice is associated with increased apoptosis

Autor: Steven D. Holladay, Larry E. Freeman, J. Claudio Gutierrez, Murali K. Mallela, M. Renee Prater, Bonnie J. Smith

Publikováno v: Birth Defects Research Part B: Developmental and Reproductive Toxicology. 86:409-415

Previous work in our laboratory showed reduced myocardium and dilated ventricular chambers in gestation day (GD) 17 hearts that were collected from hyperglycemic CD1 mouse dams. Pre-breeding maternal immune stimulation, using Freund's complete adjuva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2268f1b985be8ed4f98c553872f11d18
https://doi.org/10.1002/bdrb.20212

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Evaluation of developmental toxicity of propylthiouracil and methimazole

Autor: Murali K, Mallela, Marie, Strobl, Ryan R, Poulsen, Christopher C, Wendler, Carmen J, Booth, Scott A, Rivkees

Publikováno v: Birth defects research. Part B, Developmental and reproductive toxicology. 101(4)

Propylthiouracil (PTU) and methimazole (MMI) are antithyroid drugs used to treat hyperthyroidism. Despite the widespread use of PTU and MMI during pregnancy, modest clinical data and less animal data are available on the teratogenic potential of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22d728076f7a3bc85d67e6d66fbbdb7f
https://pubmed.ncbi.nlm.nih.gov/24980470

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