Lack of RAC1 in macrophages protects against atherosclerosis.

Autor: Sashidar Bandaru, Chandu Ala, Matias Ekstrand, Murali K Akula, Matteo Pedrelli, Xi Liu, Göran Bergström, Liliana Håversen, Jan Borén, Martin O Bergo, Levent M Akyürek

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0239284 (2020)

The Rho GTPase RAC1 is an important regulator of cytoskeletal dynamics, but the role of macrophage-specific RAC1 has not been explored during atherogenesis. We analyzed RAC1 expression in human carotid atherosclerotic plaques using immunofluorescence

Externí odkaz: https://doaj.org/article/93032c03f95f4957805f132fd801d33f

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Autor: Donghai Wang, Malin C. Erlandsson, Mohamed X. Ibrahim, Israiel T. Kumar, Christin Karlsson, Cord Brakebusch, Xiufeng Xu, Volkan I. Sayin, Maria Bokarewa, Omar M. Khan, Emil G. Ivarsson, Martin O. Bergo, Murali K. Akula, Mikael Brisslert

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Akula, M K, Ibrahim, M X, Ivarsson, E G, Khan, O M, Kumar, I T, Erlandsson, M, Karlsson, C, Xu, X, Brisslert, M, Brakebusch, C, Wang, D, Bokarewa, M, Sayin, V I & Bergo, M O 2019, ' Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions ', Nature Communications, vol. 10, no. 1, 3975, pp. 1-13 . https://doi.org/10.1038/s41467-019-11606-x

Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However, conditional deletion of GGTase-I in mouse macrophages increases GTP-loading of Rho proteins, lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c360d5eb30f609d63fd9b0c1548c5763
https://doaj.org/article/64e45db836524099a563e469b049824a

Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b

Autor: Christin, Karlsson, Murali K, Akula, Anna, Staffas, Jaroslaw, Cisowski, Volkan I, Sayin, Mohamed X, Ibrahim, Per, Lindahl, Martin O, Bergo

Publikováno v: Leukemia. 35(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::556f041b436e832504951b269a2148ba
https://pubmed.ncbi.nlm.nih.gov/32398789

Lack of RAC1 in macrophages protects against atherosclerosis

Autor: Murali K. Akula, Chandu Ala, Matias Ekstrand, Levent M. Akyürek, Göran Bergström, Xi Liu, Liliana Håversen, Matteo Pedrelli, Jan Borén, Sashidar Bandaru, Martin O. Bergo

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0239284 (2020)
PLoS ONE

The Rho GTPase RAC1 is an important regulator of cytoskeletal dynamics, but the role of macrophage-specific RAC1 has not been explored during atherogenesis. We analyzed RAC1 expression in human carotid atherosclerotic plaques using immunofluorescence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe1ed4470207769fd5d1382fe11b6d8
https://doaj.org/article/93032c03f95f4957805f132fd801d33f

OP0022 RHO EXPRESSION FACILITATES T CELL MIGRATION TO LYMPH NODES IN RESPONSE INFLAMMATION

Autor: Martin O. Bergo, I. M. Jonsson, Mikael Brisslert, Omar M. Khan, Malin C. Erlandsson, E. Malmhäll-Bah, Maria Bokarewa, Murali K. Akula, Karin M. E. Andersson

Publikováno v: Annals of the Rheumatic Diseases. 80:12.1-13

Background:Deficiency in geranylgeranyltransferase type I (GGTase-I) results in accumulation of active Rho family proteins RhoA, Rac1 and Cdc42, responsible for cell communication and migration. We reported that mice with GGTase-I deficient macrophag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17cbeda1df95b53a8053cda15c27c95b
https://doi.org/10.1136/annrheumdis-2021-eular.1323