Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Murali, Prakriya"'
Autor:
Michaela M. Novakovic, Kirill S. Korshunov, Rogan A. Grant, Megan E. Martin, Hiam A. Valencia, G. R. Scott Budinger, Jelena Radulovic, Murali Prakriya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood. In this study, we as
Externí odkaz:
https://doaj.org/article/126b49e946bc446587919a74f95203cf
Autor:
Marilena Letizia, Yin‐Hu Wang, Ulrike Kaufmann, Lorenz Gerbeth, Annegret Sand, Max Brunkhorst, Patrick Weidner, Jörn Felix Ziegler, Chotima Böttcher, Stephan Schlickeiser, Camila Fernández, Megumi Yamashita, Kenneth Stauderman, Katherine Sun, Désirée Kunkel, Murali Prakriya, IBDome Researchers, Ashley Sanders, Britta Siegmund, Stefan Feske, Carl Weidinger
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 9, Pp 1-25 (2022)
Abstract Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses. Using mass cytometry (CyTOF) to analyze the immune cell composition in the lamina propria (LP) of patients with ulcerative colitis (UC) and Crohn'
Externí odkaz:
https://doaj.org/article/997a99d779c54eab8e997f08e05290f9
Autor:
Serap Erdogmus, Axel R. Concepcion, Megumi Yamashita, Ikjot Sidhu, Anthony Y. Tao, Wenyi Li, Pedro P. Rocha, Bonnie Huang, Ralph Garippa, Boram Lee, Amy Lee, Johannes W. Hell, Richard S. Lewis, Murali Prakriya, Stefan Feske
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The function of voltage-gated calcium channels in T cells is not well understood and controversial. Here the authors report that a regulatory beta subunit of voltage-gated calcium channels regulates T cell function despite no evidence that these chan
Externí odkaz:
https://doaj.org/article/5b75fb8dc4614e899839c3361f59e74d
Publikováno v:
eLife, Vol 12 (2023)
Ca2+ release-activated Ca2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca2+ sensor. A hallmark of CRAC channels is fast Ca2+-dependent inactivation (CDI) whic
Externí odkaz:
https://doaj.org/article/cbd2b3496b3e40d2952ac2b73ceb4710
Autor:
Mohammad Mehdi Maneshi, Anna B. Toth, Toshiyuki Ishii, Kotaro Hori, Shogo Tsujikawa, Andrew K. Shum, Nisha Shrestha, Megumi Yamashita, Richard J. Miller, Jelena Radulovic, Geoffrey T. Swanson, Murali Prakriya
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108911- (2021)
Externí odkaz:
https://doaj.org/article/1e4e197b0b404284ad49a56410d982ec
Autor:
Mohammad Mehdi Maneshi, Anna B. Toth, Toshiyuki Ishii, Kotaro Hori, Shogo Tsujikawa, Andrew K. Shum, Nisha Shrestha, Megumi Yamashita, Richard J. Miller, Jelena Radulovic, Geoffrey T. Swanson, Murali Prakriya
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108464- (2020)
Summary: Store-operated Orai1 calcium channels function as highly Ca2+-selective ion channels and are broadly expressed in many tissues including the central nervous system, but their contributions to cognitive processing are largely unknown. Here, w
Externí odkaz:
https://doaj.org/article/04076d837bbd42dc9fc8fee6e1855624
Publikováno v:
eLife, Vol 9 (2020)
Sulfur-aromatic interactions occur in the majority of protein structures, yet little is known about their functional roles in ion channels. Here, we describe a novel molecular motif, the M101 gate latch, which is essential for gating of human Orai1 c
Externí odkaz:
https://doaj.org/article/6c73ba37cc954bfc9aeac83928813135
Autor:
Martin Vaeth, Jun Yang, Megumi Yamashita, Isabelle Zee, Miriam Eckstein, Camille Knosp, Ulrike Kaufmann, Peter Karoly Jani, Rodrigo S. Lacruz, Veit Flockerzi, Imre Kacskovics, Murali Prakriya, Stefan Feske
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Ca2+ release-activated Ca2+(CRAC) channels are essential for protective immunity, but the immunological functions of the three ORAI homologues that form CRAC channels are unclear. Here the authors show that ORAI1 and ORAI2 form heteromeric CRAC chann
Externí odkaz:
https://doaj.org/article/cecf348141a04e5d97c610a4720fbbd4
Autor:
Megumi Yamashita, Priscilla S.-W. Yeung, Christopher E. Ing, Beth A. McNally, Régis Pomès, Murali Prakriya
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Store-operated Ca2+channels (CRAC) are involved in several cellular functions. Here the authors identify a hydrophobic gate in the CRAC pore and show that CRAC activation by STIM1 involves rotation of the pore helix that hydrates this region to allow
Externí odkaz:
https://doaj.org/article/d822026f02ee422589e1d171ef62a857
Publikováno v:
The Journal of Physiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c0bb9dca942cbf0484e24fba3ed4606
https://doi.org/10.1113/jp283826
https://doi.org/10.1113/jp283826