Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Murali, Ganesan"'
Autor:
Grace Bybee, Youra Moeun, Weimin Wang, Kusum K. Kharbanda, Larisa Y. Poluektova, Srivatsan Kidambi, Natalia A. Osna, Murali Ganesan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHepatitis B virus (HBV) infection develops as an acute or chronic liver disease, which progresses from steatosis, hepatitis, and fibrosis to end-stage liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). An increased stromal
Externí odkaz:
https://doaj.org/article/7dce5104bbc04432b98de9d85196fe16
Autor:
Madan Kumar Arumugam, Thiyagarajan Gopal, Rakhee Rathnam Kalari Kandy, Lokesh Kumar Boopathy, Sathish Kumar Perumal, Murali Ganesan, Karuna Rasineni, Terrence M. Donohue, Natalia A. Osna, Kusum K. Kharbanda
Publikováno v:
Biology, Vol 12, Iss 10, p 1311 (2023)
The liver is a major metabolic organ that performs many essential biological functions such as detoxification and the synthesis of proteins and biochemicals necessary for digestion and growth. Any disruption in normal liver function can lead to the d
Externí odkaz:
https://doaj.org/article/4e7a482ef3c94cdc9ac00212a22e41ef
Autor:
Madan Kumar Arumugam, Srinivas Chava, Sathish Kumar Perumal, Matthew C. Paal, Karuna Rasineni, Murali Ganesan, Terrence M. Donohue, Natalia A. Osna, Kusum K. Kharbanda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Binge drinking is the most common form of excessive alcohol use. Repeated episodes of binge drinking cause multiple organ injuries, including liver damage. We previously demonstrated that chronic ethanol administration causes a decline in the intrahe
Externí odkaz:
https://doaj.org/article/eaf8e05e96324900b30d6422b63595e0
Autor:
Mojisola Ogunnaike, Srijanee Das, Samiksha S. Raut, Ashrafi Sultana, Mohammad Ullah Nayan, Murali Ganesan, Benson J. Edagwa, Natalia A. Osna, Larisa Y. Poluektova
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1208 (2023)
Chronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective at suppressing HBV replication, however, adherence to daily the
Externí odkaz:
https://doaj.org/article/a23db97f23674b67869016e146198e37
Autor:
Natalia A. Osna, Akiko Eguchi, Ariel E. Feldstein, Hidekazu Tsukamoto, Raghubendra S. Dagur, Murali Ganesan, Moses New-Aaron, Madan Kumar Arumugam, Srinivas Chava, Marcelle Ribeiro, Gyongyi Szabo, Sebastian Mueller, Shijin Wang, Cheng Chen, Steven A. Weinman, Kusum K. Kharbanda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote end-stage liv
Externí odkaz:
https://doaj.org/article/e69b5a4021114e218d339af1ed84fd39
Autor:
Kusum K. Kharbanda, Shilpa Chokshi, Irina Tikhanovich, Steven A. Weinman, Moses New-Aaron, Murali Ganesan, Natalia A. Osna
Publikováno v:
Biology, Vol 12, Iss 2, p 255 (2023)
Now, much is known regarding the impact of chronic and heavy alcohol consumption on the disruption of physiological liver functions and the induction of structural distortions in the hepatic tissues in alcohol-associated liver disease (ALD). This rev
Externí odkaz:
https://doaj.org/article/9d45aa29974e4802b1a8abd38f12c867
Autor:
Moses New-Aaron, Raghubendra Singh Dagur, Siva Sankar Koganti, Murali Ganesan, Weimin Wang, Edward Makarov, Mojisola Ogunnaike, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna
Publikováno v:
Biology, Vol 11, Iss 7, p 1059 (2022)
Recently, we found that both HIV and acetaldehyde, an alcohol metabolite, induce hepatocyte apoptosis, resulting in the release of large extracellular vesicles called apoptotic bodies (ABs). The engulfment of these hepatocyte ABs by hepatic stellate
Externí odkaz:
https://doaj.org/article/a2c88a9ccab347dcbd734c245c0ed0bc
Autor:
Murali Ganesan, Irina Tikhanovich, Shiva Shankar Vangimalla, Raghubendra Singh Dagur, Weimin Wang, Larisa I. Poluektova, Yimin Sun, David F. Mercer, Dean Tuma, Steven A. Weinman, Kusum K. Kharbanda, Natalia A. Osna
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 2, Pp 101-112 (2018)
Alcohol-induced progression of hepatitis C virus (HCV) infection is related to dysfunction of innate immunity in hepatocytes. Endogenously produced interferon (IFN)α induces activation of interferon-stimulated genes (ISGs) via triggering of the Janu
Externí odkaz:
https://doaj.org/article/28d1942e37834cfcaa1af481a8e86db9
Publikováno v:
Journal of Clinical and Experimental Hepatology. 12:1492-1513
Excessive alcohol consumption is a global healthcare problem with enormous social, economic, and clinical consequences. While chronic, heavy alcohol consumption causes structural damage and/or disrupts normal organ function in virtually every tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728763c8e347e9cc9f2484454d48ae38
https://doi.org/10.1016/j.jceh.2022.05.004
https://doi.org/10.1016/j.jceh.2022.05.004
Autor:
Moses New-Aaron, Paul G. Thomes, Murali Ganesan, Raghubendra Singh Dagur, Terrence M. Donohue, Kharbanda K. Kusum, Larisa Y. Poluektova, Natalia A. Osna
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1497 (2021)
Although the causes of hepatotoxicity among alcohol-abusing HIV patients are multifactorial, alcohol remains the least explored “second hit” for HIV-related hepatotoxicity. Here, we investigated whether metabolically derived acetaldehyde impairs
Externí odkaz:
https://doaj.org/article/dd84d8c1002949b4a33f08ac250a2f9a