Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Muniswamy M"'
Autor:
Jyoti Tanwar, Kriti Ahuja, Akshay Sharma, Paras Sehgal, Gyan Ranjan, Farina Sultan, Anushka Agrawal, Donato D'Angelo, Anshu Priya, Vamsi K Yenamandra, Archana Singh, Anna Raffaello, Muniswamy Madesh, Rosario Rizzuto, Sridhar Sivasubbu, Rajender K Motiani
Publikováno v:
PLoS Biology, Vol 22, Iss 11, p e3002895 (2024)
Mitochondria regulate several physiological functions through mitochondrial Ca2+ dynamics. However, role of mitochondrial Ca2+ signaling in melanosome biology remains unknown. Here, we show that pigmentation requires mitochondrial Ca2+ uptake. In vit
Externí odkaz:
https://doaj.org/article/0e998a933c0a4fb4bacf066d34175ce3
Autor:
Alejandro Marmolejo-Garza, Inge E. Krabbendam, Minh Danh Anh Luu, Famke Brouwer, Marina Trombetta-Lima, Osman Unal, Shane J. O’Connor, Naďa Majerníková, Carolina R. S. Elzinga, Cristina Mammucari, Martina Schmidt, Muniswamy Madesh, Erik Boddeke, Amalia M. Dolga
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-15 (2023)
Abstract Ferroptosis is an iron- and reactive oxygen species (ROS)-dependent form of regulated cell death, that has been implicated in Alzheimer’s disease and Parkinson’s disease. Inhibition of cystine/glutamate antiporter could lead to mitochond
Externí odkaz:
https://doaj.org/article/691ff9c44b724f72bdd4f4130f56e6a5
Autor:
Akshar Patel, Matthew Simkulet, Soumya Maity, Manigandan Venkatesan, Anastasios Matzavinos, Muniswamy Madesh, B. Rita Alevriadou
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The mitochondrial calcium (Ca2+) uniporter (MCU) channel is responsible for mitochondrial Ca2+ influx. Its expression was found to be upregulated in endothelial cells (ECs) under cardiovascular disease conditions. Since the role of MCU in re
Externí odkaz:
https://doaj.org/article/60992396b0f048ee90a689948b2e1637
Autor:
Travis R. Madaris, Manigandan Venkatesan, Soumya Maity, Miriam C. Stein, Neelanjan Vishnu, Mridula K. Venkateswaran, James G. Davis, Karthik Ramachandran, Sukanthathulse Uthayabalan, Cristel Allen, Ayodeji Osidele, Kristen Stanley, Nicholas P. Bigham, Terry M. Bakewell, Melanie Narkunan, Amy Le, Varsha Karanam, Kang Li, Aum Mhapankar, Luke Norton, Jean Ross, M. Imran Aslam, W. Brian Reeves, Brij B. Singh, Jeffrey Caplan, Justin J. Wilson, Peter B. Stathopulos, Joseph A. Baur, Muniswamy Madesh
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112155- (2023)
Summary: The most abundant cellular divalent cations, Mg2+ (mM) and Ca2+ (nM-μM), antagonistically regulate divergent metabolic pathways with several orders of magnitude affinity preference, but the physiological significance of this competition rem
Externí odkaz:
https://doaj.org/article/324fd2ad3fb9463fa4701a04cb364947
Autor:
Akshar Patel, Julia G. Pietromicca, Manigandan Venkatesan, Soumya Maity, Jonathan E. Bard, Muniswamy Madesh, B. Rita Alevriadou
Publikováno v:
Physiological Reports, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract Mitochondrial calcium (mCa2+) uptake occurs via the Mitochondrial Ca2+ Uniporter (MCU) complex and plays a critical role in mitochondrial dynamics, mitophagy, and apoptosis. MCU complex activity is in part modulated by the expression of its
Externí odkaz:
https://doaj.org/article/baa17e0107a140e3a0e19ab36864111a
Autor:
Hanumanthappa, D., Vasudevan, S. N., Shakuntala, N. M., Muniswamy, M., Kisan, B., Macha, I. Sangeeta
Publikováno v:
Indian Journal of Agricultural Research; Jun2018, Vol. 52 Issue 3, p250-256, 7p
Autor:
Mohammad Zulkifli, John K. Neff, Shrishiv A. Timbalia, Natalie M. Garza, Yingqi Chen, Jeramie D. Watrous, Marta Murgia, Prachi P. Trivedi, Steven K. Anderson, Dhanendra Tomar, Roland Nilsson, Muniswamy Madesh, Mohit Jain, Vishal M. Gohil
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Although some fungal mitochondria lack the calcium uniporter, many intriguingly encode homologs of the uniporter assembly factor MCUR1. Here, the authors show that in budding yeast, the MCUR1 homologs Put6 and Put7 regulate mitochondrial proline meta
Externí odkaz:
https://doaj.org/article/389bd4b04d3b4af58e574df071abb507
Autor:
Karthik Ramachandran, Soumya Maity, Alagar R. Muthukumar, Soundarya Kandala, Dhanendra Tomar, Tarek Mohamed Abd El-Aziz, Cristel Allen, Yuyang Sun, Manigandan Venkatesan, Travis R. Madaris, Kevin Chiem, Rachel Truitt, Neelanjan Vishnu, Gregory Aune, Allen Anderson, Luis Martinez, Wenli Yang, James D. Stockand, Brij B. Singh, Subramanya Srikantan, W. Brian Reeves, Muniswamy Madesh
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103722- (2022)
Summary: SARS-CoV-2 is a newly identified coronavirus that causes the respiratory disease called coronavirus disease 2019 (COVID-19). With an urgent need for therapeutics, we lack a full understanding of the molecular basis of SARS-CoV-2-induced cell
Externí odkaz:
https://doaj.org/article/6b278b5fe84c471b8072bb9b105a52c6
Autor:
Viviane Nascimento Da Conceicao, Yuyang Sun, Karthik Ramachandran, Arun Chauhan, Amritha Raveendran, Manigandan Venkatesan, Bony DeKumar, Soumya Maity, Neelanjan Vishnu, George A. Kotsakis, Paul F. Worley, Donald L. Gill, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103339- (2021)
Summary: Transformation of naive macrophages into classically (M1) or alternatively (M2) activated macrophages regulates the inflammatory response. Here, we identified that distinct Ca2+ entry channels determine the IFNγ-induced M1 or IL-4-induced M
Externí odkaz:
https://doaj.org/article/07366b1458be4b4bbeed13ff5fe16ed8
Autor:
Malik Bisserier, Santhanam Shanmughapriya, Amit Kumar Rai, Carolina Gonzalez, Agnieszka Brojakowska, Venkata Naga Srikanth Garikipati, Muniswamy Madesh, Paul J. Mills, Kenneth Walsh, Arsen Arakelyan, Raj Kishore, Lahouaria Hadri, David A. Goukassian
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 21 (2021)
Background Space travel–associated stressors such as microgravity or radiation exposure have been reported in astronauts after short‐ and long‐duration missions aboard the International Space Station. Despite risk mitigation strategies, adverse
Externí odkaz:
https://doaj.org/article/b57b30ccbbcc4c8f9af472359f306306